The simultaneous inhibition of histidine on 5-hydroxymethylfurfural and acrylamide in model systems and cookies
Sign Up to like & getrecommendations! Published in 2021 at "Food Chemistry"
DOI: 10.1016/j.foodchem.2021.131271
Abstract: Abstract 5-Hydroxymethylfurfural (HMF) and acrylamide (AA) are neo-formed food contaminants. In this study, the simultaneous inhibition of HMF and AA by histidine (His) were investigated. In the asparagine (Asn)/glucose (Glc) model system, the inhibition ratios… read more here.
Keywords: inhibition histidine; histidine hydroxymethylfurfural; inhibition; model ... See more keywords
Simultaneous inhibition of Chk1 and Bcl-xL induces apoptosis in vitro and represses tumour growth in an in vivo xenograft model.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of chemotherapy"
DOI: 10.1080/1120009x.2022.2125749
Abstract: We previously showed that prexasertib, a checkpoint kinase 1 (Chk1) inhibitor, and navitoclax, a Bcl-2 and Bcl-xL inhibitor, induced a synergistic inhibitory effect on cell proliferation in vitro. Here, we investigated the effect of the simultaneous… read more here.
Keywords: xenograft model; inhibition chk1; chk1 bcl; chk1 ... See more keywords
Simultaneous inhibition of endocytic recycling and lysosomal fusion sensitizes cells and tissues to oligonucleotide therapeutics
Sign Up to like & getrecommendations! Published in 2023 at "Nucleic Acids Research"
DOI: 10.1093/nar/gkad023
Abstract: Abstract Inefficient endosomal escape remains the primary barrier to the broad application of oligonucleotide therapeutics. Liver uptake after systemic administration is sufficiently robust that a therapeutic effect can be achieved but targeting extrahepatic tissues remains… read more here.
Keywords: fusion; lysosomal fusion; endocytic recycling; activity ... See more keywords
Simultaneous inhibition of PD-1 and LAG-3: the future of immunotherapy?
Sign Up to like & getrecommendations! Published in 2023 at "Immunotherapy"
DOI: 10.2217/imt-2022-0185
Abstract: Immunotherapy has improved the prognosis of many cancers, yet a large number of patients have demonstrated resistance to current immune checkpoint inhibitors. LAG-3 is an immune checkpoint expressed on tumor-infiltrating lymphocytes CD4+ and CD8+, Tregs… read more here.
Keywords: lag; immune checkpoint; immunotherapy; immunotherapy simultaneous ... See more keywords
Simultaneous Inhibition of Thrombosis and Inflammation Is Beneficial in Treating Acute Myocardial Infarction
Sign Up to like & getrecommendations! Published in 2023 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms24087333
Abstract: Myocardial ischemia reperfusion injury (IRI) in acute coronary syndromes is a condition in which ischemic/hypoxic injury to cells subtended by the occluded vessel continues despite successful resolution of the thrombotic obstruction. For decades, most efforts… read more here.
Keywords: inhibition; thrombosis inflammation; inhibition thrombosis; simultaneous inhibition ... See more keywords