Therapeutic effects of moxibustion simultaneously targeting Nrf2 and NF-κB in diabetic peripheral neuropathy
Sign Up to like & getrecommendations! Published in 2019 at "Applied Biochemistry and Biotechnology"
DOI: 10.1007/s12010-019-03052-8
Abstract: Moxibustion is the main alternative medicine treatment that has been beneficial to diabetic peripheral neuropathy (DPN), a common complication secondary to diabetic microvascular injury. However, the underlying protective mechanism of moxibustion against neuroinflammation remains unclear.… read more here.
Keywords: moxibustion; peripheral neuropathy; simultaneously targeting; targeting nrf2 ... See more keywords
Design, Synthesis, and Biological Evaluation of 4-Methyl Quinazoline Derivatives as Anticancer Agents Simultaneously Targeting Phosphoinositide 3-Kinases and Histone Deacetylases.
Sign Up to like & getrecommendations! Published in 2019 at "Journal of medicinal chemistry"
DOI: 10.1021/acs.jmedchem.9b00390
Abstract: Polypharmacology is a promising paradigm in modern drug discovery. Herein, we have discovered a series of novel PI3K and HDAC dual inhibitors in which the hydroxamic acid moiety as the zinc binding functional group was… read more here.
Keywords: quinazoline; design synthesis; biological evaluation; simultaneously targeting ... See more keywords
Simultaneously Targeting Myofibroblast Contractility and Extracellular Matrix Cross‐Linking as a Therapeutic Concept in Airway Fibrosis
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DOI: 10.1111/ajt.14103
Abstract: Fibrosis after solid organ transplantation is considered an irreversible process and remains the major cause of graft dysfunction and death with limited therapies. This remodeling is characterized by aberrant accumulation of contractile myofibroblasts that deposit… read more here.
Keywords: targeting myofibroblast; extracellular matrix; matrix; simultaneously targeting ... See more keywords