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   Articles with "simvastatin" as a keyword



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Bioconversion of lovastatin to simvastatin by Streptomyces carpaticus toward the inhibition of HMG-CoA activity.

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recommendations! Published in 2022 at "Biotechnology and applied biochemistry"

DOI: 10.1002/bab.2429

Abstract: The aim of this study was the modification of lovastatin by microbes to improve its potential. Actinobacteria exhibit staggering diversity in terms of their biosynthetic capability for specialized metabolites which has been traced back to… read more here.

Keywords: hmg coa; analysis; simvastatin; lovastatin ... See more keywords
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Astragaloside IV reverses simvastatin‐induced skeletal muscle injury by activating the AMPK‐PGC‐1α signalling pathway

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recommendations! Published in 2019 at "Phytotherapy Research"

DOI: 10.1002/ptr.6593

Abstract: In this study, we investigated the effect of astragaloside IV on skeletal muscle energy metabolism disorder caused by statins and explored the possible mechanisms. High‐fat diet‐fed apolipoprotein E knockout (ApoE−/−) mice performed aerobic exercise and… read more here.

Keywords: skeletal muscle; simvastatin; muscle; muscle injury ... See more keywords
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In vitro and in vivo evaluation of chitosan scaffolds combined with simvastatin-loaded nanoparticles for guided bone regeneration

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recommendations! Published in 2019 at "Journal of Materials Science: Materials in Medicine"

DOI: 10.1007/s10856-019-6249-3

Abstract: AbstractThe objective of this study was to fabricate and characterize chitosan combined with different amounts of simvastatin-loaded nanoparticles and to investigate their potential for guided bone regeneration in vitro and in vivo. Different SIM-CSN formulations… read more here.

Keywords: simvastatin loaded; simvastatin; loaded nanoparticles; bone regeneration ... See more keywords
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Simvastatin-Loaded PEGylated Solid Lipid Nanoparticles: Lipid Functionalization to Improve Blood Circulation

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recommendations! Published in 2020 at "BioNanoScience"

DOI: 10.1007/s12668-020-00770-w

Abstract: The aim of the present work was to formulate simvastatin-loaded PEGylated solid lipid nanoparticles (PEG-SLNs) for prolonging blood circulation. Plain solid lipid nanoparticles (P-SLNs) were prepared by ethanol injection method. Prepared P-SLNs were PEGylated using… read more here.

Keywords: peg slns; simvastatin; slns; lipid nanoparticles ... See more keywords
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Comparative potential of Simvastatin, Rosuvastatin and Fluvastatin against bacterial infection: an in silico and in vitro study

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recommendations! Published in 2019 at "Oriental Pharmacy and Experimental Medicine"

DOI: 10.1007/s13596-019-00359-z

Abstract: In the current investigation, we have compared the potential of statin drugs (Simvastatin, Rosuvastatin and Fluvastatin) as potential anti-bacterial agent by conducting in silico, in vitro and ex vivo studies. In silico study was conducted… read more here.

Keywords: simvastatin; study; silico vitro; simvastatin rosuvastatin ... See more keywords
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Simvastatin ameliorates altered mechanotransduction in uterine leiomyoma cells.

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recommendations! Published in 2020 at "American journal of obstetrics and gynecology"

DOI: 10.1016/j.ajog.2020.05.012

Abstract: BACKGROUND Uterine leiomyomas, the most common tumors of the female reproductive system, feature excessive deposition of disordered stiff extracellular matrix (ECM) and fundamentally altered mechanical signaling pathways . Specifically, these alterations impact the normal dynamic… read more here.

Keywords: leiomyoma cells; altered mechanotransduction; simvastatin; mechanical signaling ... See more keywords
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Simvastatin affects the PPARα signaling pathway and causes oxidative stress and embryonic development interference in Mugilogobius abei.

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recommendations! Published in 2021 at "Aquatic toxicology"

DOI: 10.1016/j.aquatox.2021.105951

Abstract: Simvastatin (SV) is a common hypolipidemic drug in clinical medicine that can reduce endogenous cholesterol biosynthesis by inhibiting hydroxyl-methyl-glutaryl coenzyme A reductase. SV took a large market share in the lipid-lowering drugs and it is… read more here.

Keywords: simvastatin; mugilogobius abei; embryonic development; abei ... See more keywords

Mechanisms of insulin resistance by simvastatin in C2C12 myotubes and in mouse skeletal muscle.

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recommendations! Published in 2019 at "Biochemical pharmacology"

DOI: 10.1016/j.bcp.2019.02.025

Abstract: Statins inhibit cholesterol biosynthesis and lower serum LDL-cholesterol levels. They are generally well tolerated, but can cause insulin resistance in patients. Therefore, we investigated the mechanisms underlying the statin-induced insulin resistance. We used mice and… read more here.

Keywords: c2c12 myotubes; simvastatin; phosphorylation; insulin resistance ... See more keywords

Microparticle-embedded fibroin/alginate beads for prolonged local release of simvastatin hydroxyacid to mesenchymal stem cells.

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recommendations! Published in 2017 at "Carbohydrate polymers"

DOI: 10.1016/j.carbpol.2017.08.045

Abstract: In the present work, we propose silk fibroin/alginate (SF/Alg) beads embedding simvastatin-loaded biodegradable microparticles as a versatile platform capable of tuning SVA release and in so doing osteogenic effects. In a first part of the… read more here.

Keywords: fibroin alginate; simvastatin; release; loaded microparticles ... See more keywords
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Inverse screening of Simvastatin kinase targets from glioblastoma druggable kinome

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recommendations! Published in 2020 at "Computational biology and chemistry"

DOI: 10.1016/j.compbiolchem.2020.107243

Abstract: The statin drug Simvastatin is a HMG-CoA reductase inhibitor that has been widely used to lower blood lipid. However, the drug is clinically observed to reposition a significant suppressing potency on glioblastoma (GBM) by unexpectedly… read more here.

Keywords: inverse screening; simvastatin; kinase; druggable kinome ... See more keywords
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Simvastatin, at clinically relevant concentrations, affects human uterine leiomyoma growth and extracellular matrix production.

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recommendations! Published in 2018 at "Fertility and sterility"

DOI: 10.1016/j.fertnstert.2018.07.024

Abstract: OBJECTIVE To observe the antifibroid effects of therapeutic concentrations of simvastatin, which interferes with cholesterol biosynthesis, a known precursor of five major classes of steroid hormones, including progesterone and estrogen, which play a major role… read more here.

Keywords: leiomyoma cells; production; simvastatin; extracellular matrix ... See more keywords