Preformulation Studies of Ezetimibe-Simvastatin Solid Dispersions in the Development of Fixed-Dose Combinations
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DOI: 10.3390/pharmaceutics14050912
Abstract: Two active pharmaceutical ingredients (APIs) with limited solubility, simvastatin and ezetimibe, prepared as a drug-drug solid dispersion (SD) was evaluated for physicochemical, microstructural, and aqueous dissolution properties. The simvastatin-ezetimibe SD was prepared using the co-grinding… read more here.
Keywords: ezetimibe simvastatin; development; fixed dose; preformulation studies ... See more keywords