Astragaloside IV reverses simvastatin‐induced skeletal muscle injury by activating the AMPK‐PGC‐1α signalling pathway
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DOI: 10.1002/ptr.6593
Abstract: In this study, we investigated the effect of astragaloside IV on skeletal muscle energy metabolism disorder caused by statins and explored the possible mechanisms. High‐fat diet‐fed apolipoprotein E knockout (ApoE−/−) mice performed aerobic exercise and… read more here.
Keywords: skeletal muscle; simvastatin; muscle; muscle injury ... See more keywords
Mechanisms of simvastatin myotoxicity: The role of autophagy flux inhibition.
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DOI: 10.1016/j.ejphar.2019.172616
Abstract: Statins are some of the most widely used drugs worldwide, but one of their major side effects is myotoxicity. Using mouse myoblast (C2C12) and human alveolar rhabdomyosarcoma cell lines (RH30) in 2-dimensional (2D) and 3-dimensional… read more here.
Keywords: myotoxicity; simvastatin induced; c2c12; simvastatin myotoxicity ... See more keywords
Proinsulin C-Peptide Enhances Cell Survival and Protects against Simvastatin-Induced Myotoxicity in L6 Rat Myoblasts
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DOI: 10.3390/ijms20071654
Abstract: The repair capacity of progenitor skeletal muscle satellite cells (SC) in Type 1 diabetes mellitus (T1DM) is decreased. This is associated with the loss of skeletal muscle function. In T1DM, the deficiency of C-peptide along… read more here.
Keywords: skeletal muscle; cell survival; muscle; induced myotoxicity ... See more keywords