A new underlying mechanism for the neuroprotective effect of bosutinib: Reverting toxicity-induced PARylation in SIN1-mediated neurotoxicity.
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DOI: 10.1002/jbt.22915
Abstract: Increased levels of reactive oxygen and nitrogen species play an important role in the development and progression of neurodegenerative diseases, such as Alzheimer's and Parkinson's disease. The overproduction of these highly reactive chemical species leads… read more here.
Keywords: bos; mechanism neuroprotective; parylation; effect ... See more keywords