Transcriptome Analysis of Schwann Cells at Various Stages of Myelination Implicates Chromatin Regulator Sin3A in Control of Myelination Identity.
Sign Up to like & getrecommendations! Published in 2022 at "Neuroscience bulletin"
DOI: 10.1007/s12264-022-00850-9
Abstract: Enhancing remyelination after injury is of utmost importance for optimizing the recovery of nerve function. While the formation of myelin by Schwann cells (SCs) is critical for the function of the peripheral nervous system, the… read more here.
Keywords: nerve; various stages; control; myelination ... See more keywords
SINHCAF/FAM60A and SIN3A specifically repress HIF-2α expression
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DOI: 10.1042/bcj20170945
Abstract: The SIN3A–HDAC (histone deacetylase) complex is a master transcriptional repressor, required for development but often deregulated in disease. Here, we report that the recently identified new component of this complex, SINHCAF (SIN3A and HDAC-associated factor)/FAM60A… read more here.
Keywords: hif; sinhcaf fam60a; sin3a hdac; sinhcaf ... See more keywords
Sin3a–Tet1 interaction activates gene transcription and is required for embryonic stem cell pluripotency
Sign Up to like & getrecommendations! Published in 2018 at "Nucleic Acids Research"
DOI: 10.1093/nar/gky347
Abstract: Abstract Sin3a is a core component of histone-deacetylation-activity-associated transcriptional repressor complex, playing important roles in early embryo development. Here, we reported that down-regulation of Sin3a led to the loss of embryonic stem cell (ESC) self-renewal… read more here.
Keywords: sin3a tet1; sin3a; tet1 interaction; stem cell ... See more keywords
The Transcriptional Regulator Sin3A Contributes to the Oncogenic Potential of STAT3.
Sign Up to like & getrecommendations! Published in 2019 at "Cancer research"
DOI: 10.1158/0008-5472.can-18-0359
Abstract: Epigenetic silencing of promoter and enhancer regions is a common phenomenon in malignant cells. The transcription factor STAT3 is aberrantly activated in several tumors, where its constitutive acetylation accounts for the transcriptional repression of a… read more here.
Keywords: stat3; stat3 acetylation; sin3a; cell ... See more keywords
Regulation of the Methylation and Expression Levels of the BMPR2 Gene by SIN3a as a Novel Therapeutic Mechanism in Pulmonary Arterial Hypertension
Sign Up to like & getrecommendations! Published in 2021 at "Circulation"
DOI: 10.1161/circulationaha.120.047978
Abstract: Supplemental Digital Content is available in the text. Background: Epigenetic mechanisms are critical in the pathogenesis of pulmonary arterial hypertension (PAH). Previous studies have suggested that hypermethylation of the BMPR2 (bone morphogenetic protein receptor type… read more here.
Keywords: expression; bmpr2; pulmonary arterial; sin3a ... See more keywords
Electroacupuncture reduces scopolamine-induced amnesia via mediating the miR-210/SIN3A and miR-183/SIN3A signaling pathway
Sign Up to like & getrecommendations! Published in 2020 at "Molecular Medicine"
DOI: 10.1186/s10020-020-00233-8
Abstract: Background The expression of SIN3A is closely correlated with electroacupuncture (EA) treatment efficacy of scopolamine-induced amnesia (SIA), but its underlying mechanisms remain to be further explored. Methods Quantitative real-time PCR was performed to analyze the… read more here.
Keywords: sia; mir 183; sin3a; expression ... See more keywords