Haploinsufficiency of the Sin3/HDAC corepressor complex member SIN3B causes a syndromic intellectual disability/autism spectrum disorder.
Sign Up to like & getrecommendations! Published in 2021 at "American journal of human genetics"
DOI: 10.1016/j.ajhg.2021.03.017
Abstract: Proteins involved in transcriptional regulation harbor a demonstrated enrichment of mutations in neurodevelopmental disorders. The Sin3 (Swi-independent 3)/histone deacetylase (HDAC) complex plays a central role in histone deacetylation and transcriptional repression. Among the two vertebrate… read more here.
Keywords: intellectual disability; autism; haploinsufficiency; sin3b ... See more keywords
The potential of targeting Sin3B and its associated complexes for cancer therapy
Sign Up to like & getrecommendations! Published in 2017 at "Expert Opinion on Therapeutic Targets"
DOI: 10.1080/14728222.2017.1386655
Abstract: ABSTRACT Introduction: Sin3B serves as a scaffold for chromatin-modifying complexes that repress gene transcription to regulate distinct biological processes. Sin3B-containing complexes are critical for cell cycle withdrawal, and abrogation of Sin3B-dependent cell cycle exit impacts… read more here.
Keywords: sin3b containing; containing complexes; sin3b; targeting sin3b ... See more keywords
SIN3B promotes integrin αV subunit gene transcription and cell migration of hepatocellular carcinoma
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Molecular Cell Biology"
DOI: 10.1093/jmcb/mjy050
Abstract: Abstract Paired amphipathic helix protein (SIN3B) is a transcription corepressor for many genes. Here we show a different regulation mechanism of integrin αV gene expression by SIN3B in human hepatocellular carcinoma (HCC). We first observed… read more here.
Keywords: hepatocellular carcinoma; sin3b; integrin subunit; gene ... See more keywords