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   Articles with "sin3b" as a keyword



SIN3B Loss Heats up Cold Tumor Microenvironment to Boost Immunotherapy in Pancreatic Cancer

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recommendations! Published in 2024 at "Advanced Science"

DOI: 10.1002/advs.202402244

Abstract: Despite progress significant advances in immunotherapy for some solid tumors, pancreatic ductal adenocarcinoma (PDAC) remains unresponsive poorly responsive to such interventions, largely due to its highly immunosuppressive tumor microenvironment (TME) with limited CD8+ T cell… read more here.

Keywords: sin3b; cell; tumor; sin3b loss ... See more keywords
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Haploinsufficiency of the Sin3/HDAC corepressor complex member SIN3B causes a syndromic intellectual disability/autism spectrum disorder.

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recommendations! Published in 2021 at "American journal of human genetics"

DOI: 10.1016/j.ajhg.2021.03.017

Abstract: Proteins involved in transcriptional regulation harbor a demonstrated enrichment of mutations in neurodevelopmental disorders. The Sin3 (Swi-independent 3)/histone deacetylase (HDAC) complex plays a central role in histone deacetylation and transcriptional repression. Among the two vertebrate… read more here.

Keywords: intellectual disability; autism; haploinsufficiency; sin3b ... See more keywords

The potential of targeting Sin3B and its associated complexes for cancer therapy

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recommendations! Published in 2017 at "Expert Opinion on Therapeutic Targets"

DOI: 10.1080/14728222.2017.1386655

Abstract: ABSTRACT Introduction: Sin3B serves as a scaffold for chromatin-modifying complexes that repress gene transcription to regulate distinct biological processes. Sin3B-containing complexes are critical for cell cycle withdrawal, and abrogation of Sin3B-dependent cell cycle exit impacts… read more here.

Keywords: sin3b containing; containing complexes; sin3b; targeting sin3b ... See more keywords

SIN3B promotes integrin αV subunit gene transcription and cell migration of hepatocellular carcinoma

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recommendations! Published in 2019 at "Journal of Molecular Cell Biology"

DOI: 10.1093/jmcb/mjy050

Abstract: Abstract Paired amphipathic helix protein (SIN3B) is a transcription corepressor for many genes. Here we show a different regulation mechanism of integrin αV gene expression by SIN3B in human hepatocellular carcinoma (HCC). We first observed… read more here.

Keywords: hepatocellular carcinoma; sin3b; integrin subunit; gene ... See more keywords