Sinensetin isolated from Orthosiphon aristatus inhibits cell proliferation and induces apoptosis in hepatocellular carcinoma cells
Sign Up to like & getrecommendations! Published in 2020 at "Process Biochemistry"
DOI: 10.1016/j.procbio.2019.09.031
Abstract: Abstract Orthosiphon aristatus is a traditional folk medicine extensively used in Southeast Asia because of its various pharmacological effects, including antioxidant, antitumor, and hypoglycemic activities. Orthosiphon extracts have been found to be cytotoxic to hepatocellular… read more here.
Keywords: hepatocellular carcinoma; orthosiphon aristatus; sinensetin; sinensetin isolated ... See more keywords
Vasorelaxant effect of sinensetin via the NO/sGC/cGMP pathway and potassium and calcium channels
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DOI: 10.1038/s41440-018-0083-8
Abstract: Orthosiphon stamineus Benth. (Lambiaceae) is an important traditional plant for the treatment of hypertension. Previous studies have demonstrated that the sinensetin content in O. stamineus is correlated with its vasorelaxant activity. However, there is still… read more here.
Keywords: vasorelaxant effect; blocker; sinensetin; calcium ... See more keywords
Sinensetin interferes with Staphylococcus aureus infections by targeting Staphylocoagulase and improves infection survival rates in mouse model of pneumonia.
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DOI: 10.1093/jambio/lxae235
Abstract: AIMS Coagulase (Coa), a crucial virulence factor of Staphylococcus aureus (S. aureus), is considered an vital target for anti-virulence strategies. The research aimed to discover a natural compound capable of inhibiting S. aureus infection by… read more here.
Keywords: coa; survival rates; sinensetin; aureus infections ... See more keywords