Adoption of single agent anticancer therapy for advanced hepatocellular carcinoma and impact of facility type, insurance status, and income on survival: Analysis of the national cancer database 2004–2014
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DOI: 10.1002/cam4.3985
Abstract: This study analyzes the pattern of use of single agent anticancer therapy (SAACT) in the treatment and survival of advanced hepatocellular carcinoma (aHCC) before and after sorafenib was FDA approved in 2007. read more here.
Keywords: hepatocellular carcinoma; single agent; agent anticancer; advanced hepatocellular ... See more keywords
Single‐agent gemcitabine in patients with advanced, pre‐treated angiosarcoma: A multicenter, retrospective study
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DOI: 10.1002/cam4.5147
Abstract: Gemcitabine has shown clinical activity against angiosarcoma in small series, alone, or combined with taxanes. We aimed to evaluate its activity as a single‐agent in a larger series of patients with advanced angiosarcoma. We retrospectively… read more here.
Keywords: single agent; patients advanced; agent gemcitabine; gemcitabine ... See more keywords
A PHASE 2B RANDOMIZED STUDY OF SINGLE AGENT SELINEXOR IN PATIENTS WITH RELAPSED/REFRACTORY DIFFUSE LARGE B‐CELL LYMPHOMA (DLBCL)
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DOI: 10.1002/hon.2438_53
Abstract: high‐dose steroids. All patients have efficacy reassessment after RLI window with an ORR of 82% and CR rate of 42%. The 6 patients who have completed all therapy have all achieved a CR. Conclusions: The… read more here.
Keywords: single agent; study single; randomized study; study ... See more keywords
Evaluation of classical clinical endpoints as surrogates for overall survival in patients treated with immune checkpoint blockers: a systematic review and meta-analysis
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DOI: 10.1007/s00432-018-2738-x
Abstract: PurposeClassical clinical endpoints [e.g., objective response rate (ORR), disease control rate (DCR), and progression-free survival (PFS)] may not be appropriate for immune checkpoint blockers (ICBs). We evaluated correlations between these endpoints and overall survival (OS)… read more here.
Keywords: single agent; analysis; rate; month pfs ... See more keywords
Complete remission after concurrent single-agent S-1 chemoradiotherapy for stage IIIB esophageal cancer: an autopsy case report
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DOI: 10.1007/s12328-022-01634-4
Abstract: Chemoradiotherapy regimens for patients with esophageal cancer intolerant to standard therapies remain to be established. The standard therapy for patients with stage II–III esophageal squamous cell carcinoma, who are not surgical candidates, is definitive chemoradiotherapy… read more here.
Keywords: stage iiib; esophageal cancer; complete remission; chemoradiotherapy ... See more keywords
Role of Single-Agent Methotrexate as a Neoadjuvant Chemotherapy in Oral Cavity Cancers
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DOI: 10.1007/s13193-018-0846-3
Abstract: Oral cancers are the most common cancer in India due to tobacco abuse in the form of chewing, smoking, and inhalation. Majority of these patients present late at advanced disease stage. Such patients have significant… read more here.
Keywords: single agent; neoadjuvant chemotherapy; agent methotrexate; methotrexate ... See more keywords
Expert Statement on the Single-Agent Use of Inhaled Bronchodilator in the Treatment of Stable Mild-Moderate Chronic Obstructive Pulmonary Disease
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DOI: 10.1016/j.arbr.2017.08.013
Abstract: Abstract Objective To describe the evidence- and experience-based expert consensus on the use of single-agent bronchodilators in patients with stable mild-moderate chronic obstructive pulmonary disease (COPD). Methods Using Delphi methodology, a panel of 7 respiratory… read more here.
Keywords: medicine; single agent; agent bronchodilators; stable mild ... See more keywords
Multitask assignments with adverse selection
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DOI: 10.1016/j.econlet.2019.05.014
Abstract: In a simple multitask assignments model with adverse selection, we derive the optimal contracts when the principal assigns two tasks to different agents or to a single agent. Assigning tasks to different agents introduces a… read more here.
Keywords: multitask assignments; adverse selection; assignments adverse; single agent ... See more keywords
Evaluation of the effects of RP5063, a novel, multimodal, serotonin receptor modulator, as single‐agent therapy and co‐administrated with sildenafil, bosentan, and treprostinil in a monocrotaline‐induced pulmonary arterial hypertension rat model
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DOI: 10.1016/j.ejphar.2018.02.017
Abstract: Abstract Pulmonary arterial hypertension (PAH), a condition that is defined by pulmonary vasculature constriction and remodeling, involves dysfunctional signaling of the serotonin (5‐HT) receptors, 5‐HT2A/2B/7. In a rat model of monocrotaline (MCT)‐induced PAH, the effectiveness… read more here.
Keywords: single agent; agent; arterial hypertension; pulmonary arterial ... See more keywords
Comparative analysis between combination and single-agent chemotherapy for elderly patients with advanced non-small cell lung cancer: A nationwide population-based outcome study.
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DOI: 10.1016/j.lungcan.2018.05.028
Abstract: INTRODUCTION To determine whether an upfront combination compared to single-agent therapy is beneficial for elderly patients with advanced non-small cell lung cancer (NSCLC) in the real world, a population-based epidemiologic study was conducted. METHODS Patients… read more here.
Keywords: combination; lung cancer; single agent;
Phase II trial of single agent amrubicin in patients with previously treated advanced thymic malignancies.
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DOI: 10.1016/j.lungcan.2019.09.015
Abstract: OBJECTIVES There are limited treatment options for patients with thymic malignancies. Here we present data supporting treatment with single agent amrubicin, a third generation anthracycline and topoisomerase II inhibitor. MATERIALS AND METHODS This was a… read more here.
Keywords: agent; single agent; thymic malignancies; amrubicin patients ... See more keywords