Mutational analyses identify a single amino acid critical for colour tuning in proteorhodopsins
Sign Up to like & getrecommendations! Published in 2022 at "FEBS Letters"
DOI: 10.1002/1873-3468.14297
Abstract: Microbial rhodopsins are light‐activated proteins that contain seven transmembrane alpha‐helices. Spectral tuning in microbial rhodopsins is a useful optogenetic tool. In this study, we report a new site that controls spectral tuning. In the proteorhodopsins… read more here.
Keywords: single amino; amino acid; spectral tuning; tuning proteorhodopsins ... See more keywords
A single amino acid change in hemagglutinin reduces the cross-reactivity of antiserum against an equine influenza vaccine strain
Sign Up to like & getrecommendations! Published in 2019 at "Archives of Virology"
DOI: 10.1007/s00705-019-04328-4
Abstract: Equine influenza virus is an important pathogen for the horse industry because of its economic impact, and vaccination is a key control measure. Our previous work suggested that a mutation at position 144 in the… read more here.
Keywords: vaccine strain; reduces cross; equine influenza; vaccine ... See more keywords
Personalized Proteome: Comparing Proteogenomics and Open Variant Search Approaches for Single Amino Acid Variant Detection
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Proteome Research"
DOI: 10.1021/acs.jproteome.1c00264
Abstract: Discovery of variant peptides such as a single amino acid variant (SAAV) in shotgun proteomics data is essential for personalized proteomics. Both the resolution of shotgun proteomics methods and the search engines have improved dramatically,… read more here.
Keywords: acid variant; amino acid; search; single amino ... See more keywords
Modulation of Mechanical Properties of Short Bioinspired Peptide Materials by Single Amino-Acid Mutations.
Sign Up to like & getrecommendations! Published in 2023 at "Journal of the American Chemical Society"
DOI: 10.1021/jacs.2c09853
Abstract: The occurrence of modular peptide repeats in load-bearing (structural) proteins is common in nature, with distinctive peptide sequences that often remain conserved across different phylogenetic lineages. These highly conserved peptide sequences endow specific mechanical properties… read more here.
Keywords: modulation mechanical; single amino; amino acid; properties short ... See more keywords
Single Amino Acid Modifications for Controlling the Helicity of Peptide-Based Chiral Gold Nanoparticle Superstructures
Sign Up to like & getrecommendations! Published in 2023 at "Journal of the American Chemical Society"
DOI: 10.1021/jacs.3c00827
Abstract: Assembling nanoparticles (NPs) into well-defined superstructures can lead to emergent collective properties that depend on their 3-D structural arrangement. Peptide conjugate molecules designed to both bind to NP surfaces and direct NP assembly have proven… read more here.
Keywords: peptide based; structure; peptide conjugate; peptide ... See more keywords
A Single Amino Acid Switch Alters the Isoprene Donor Specificity in RiPP Prenyltransferases
Sign Up to like & getrecommendations! Published in 2018 at "Journal of the American Chemical Society"
DOI: 10.1021/jacs.8b05187
Abstract: Mutation at a single amino acid alters the isoprene donor specificity of prenyltransferases involved in the modification of ribosomally synthesized and post-translationally modified peptides (RiPPs). While most characterized RiPP prenyltransferases carry out the regiospecific transfer… read more here.
Keywords: donor specificity; amino acid; single amino;
Single amino acid utilization for bacterial categorization
Sign Up to like & getrecommendations! Published in 2020 at "Scientific Reports"
DOI: 10.1038/s41598-020-69686-5
Abstract: Despite great advancement in genetic typing, phenotyping is still an indispensable tool for categorization of bacteria. Certain amino acids may be essential for bacterial survival, growth, pathogenicity or toxin production, which prompts the idea that… read more here.
Keywords: amino; amino acid; acid consumption; bacterial categorization ... See more keywords
A single amino acid enzyme
Sign Up to like & getrecommendations! Published in 2019 at "Nature Catalysis"
DOI: 10.1038/s41929-019-0379-3
Abstract: Enzymes require many, often hundreds, of amino acid residues arranged in a protein fold to promote catalysis. Now, self-assembly of a single amino acid — phenylalanine — in the presence of zinc is shown to… read more here.
Keywords: amino acid; single amino; acid enzyme;
Analysis of single amino acid variations in singlet hot spots of protein‐protein interfaces
Sign Up to like & getrecommendations! Published in 2018 at "Bioinformatics"
DOI: 10.1093/bioinformatics/bty569
Abstract: Motivation Single amino acid variations (SAVs) in protein‐protein interaction (PPI) sites play critical roles in diseases. PPI sites (interfaces) have a small subset of residues called hot spots that contribute significantly to the binding energy,… read more here.
Keywords: amino acid; acid variations; protein protein; singlet hot ... See more keywords
A single amino acid exchange converts FocA into a unidirectional efflux channel for formate
Sign Up to like & getrecommendations! Published in 2022 at "Microbiology"
DOI: 10.1099/mic.0.001132
Abstract: During mixed-acid fermentation, Escherichia coli initially translocates formate out of the cell, but re-imports it at lower pH. This is performed by FocA, the archetype of the formate-nitrite transporter (FNT) family of pentameric anion channels.… read more here.
Keywords: formate; single amino; amino acid; efflux ... See more keywords
Pathogenicity Prediction of Single Amino Acid Variants with Machine Learning Model Based on Protein Structural Energies.
Sign Up to like & getrecommendations! Published in 2021 at "IEEE/ACM transactions on computational biology and bioinformatics"
DOI: 10.1109/tcbb.2021.3139048
Abstract: The most popular tools for predicting pathogenicity of single amino acid variants (SAVs) were developed based on sequence-based techniques. SAVs may change protein structure and function. In the context of van der Waals force and… read more here.
Keywords: pathogenicity; acid variants; single amino; prediction ... See more keywords