Cetuximab Rechallenge Plus Avelumab in Pretreated Patients With RAS Wild-type Metastatic Colorectal Cancer: The Phase 2 Single-Arm Clinical CAVE Trial.
Sign Up to like & getrecommendations! Published in 2021 at "JAMA oncology"
DOI: 10.1001/jamaoncol.2021.2915
Abstract: Importance Rechallenge therapy with anti-epidermal growth factor receptor (EGFR) drugs has been suggested in patients with chemo-refractory RAS wild-type (WT) metastatic colorectal cancer (mCRC) after initial response to anti-EGFR-based first-line treatment. The association of treatment… read more here.
Keywords: trial; cetuximab; months months; rechallenge ... See more keywords
Patient‐centered communication tool for older patients with acute myeloid leukemia, their caregivers, and oncologists: A single‐arm pilot study
Sign Up to like & getrecommendations! Published in 2022 at "Cancer Medicine"
DOI: 10.1002/cam4.5547
Abstract: In a single‐arm pilot study, we assessed the feasibility and usefulness of an innovative patient‐centered communication tool (UR‐GOAL tool) that addresses aging‐related vulnerabilities, patient values, and prognostic awareness for use in treatment decision making between… read more here.
Keywords: tool; single arm; arm pilot; patient centered ... See more keywords
Single‐arm trials for US Food and Drug Administration cancer drug approvals
Sign Up to like & getrecommendations! Published in 2023 at "Cancer"
DOI: 10.1002/cncr.34830
Abstract: O ver the past couple of decades, the US Food and Drug Administration (FDA) has increasingly used data from single-arm trials to approve cancer drugs. Of the 563 new oncology drug indications approved by the… read more here.
Keywords: oncology; food drug; single arm; drug ... See more keywords
Adherence to evidence‐based surgical metrics improves outcomes in lung cancer
Sign Up to like & getrecommendations! Published in 2023 at "Cancer"
DOI: 10.1002/cncr.34831
Abstract: 1627 such as progression-free survival or overall survival and are limited in assessing safety. Nevertheless, Dr Agrawal believes that oncologists can have confidence in the approvals based on single-arm studies. “Many approvals based on single-arm… read more here.
Keywords: oncology; approval; arm; single arm ... See more keywords
Effectiveness of Telemedicine Prescribing and a Long-Acting Obesity Medication Behavioral Program: A 24-Week Single-Arm Study.
Sign Up to like & getrecommendations! Published in 2025 at "Obesity"
DOI: 10.1002/oby.70056
Abstract: OBJECTIVE Limited data exist on telemedicine prescribing of semaglutide and tirzepatide. The effects of a telehealth obesity management program combining the provision of semaglutide and tirzepatide with a behavioral program tailored for long-acting antiobesity medications… read more here.
Keywords: behavioral program; single arm; telemedicine prescribing; long acting ... See more keywords
Use of quantitative bias analysis to evaluate single‐arm trials with real‐world data external controls
Sign Up to like & getrecommendations! Published in 2024 at "Pharmacoepidemiology and Drug Safety"
DOI: 10.1002/pds.5796
Abstract: Use of real‐world data (RWD) for external controls added to single‐arm trials (SAT) is increasingly prevalent in regulatory submissions. Due to inherent differences in the data‐generating mechanisms, biases can arise. This paper aims to illustrate… read more here.
Keywords: external controls; use quantitative; single arm; real world ... See more keywords
Transarterial Chemoembolization with Epirubicin-Loaded Microspheres for Hepatocellular Carcinoma: A Prospective, Single-Arm, Multicenter, Phase 2 Study (STOPPER Trial)
Sign Up to like & getrecommendations! Published in 2024 at "Cardiovascular and Interventional Radiology"
DOI: 10.1007/s00270-024-03666-4
Abstract: While the role of drug-eluting beads transarterial chemoembolization (DEB-TACE) for hepatocellular carcinoma (HCC) is established, questions regarding appropriate bead size for use in patients remain. This trial evaluated the effectiveness and safety of DEB-TACE using… read more here.
Keywords: epirubicin loaded; study; single arm; trial ... See more keywords
Nab-paclitaxel plus S-1 as first-line followed by S-1 maintenance for advanced pancreatic adenocarcinoma: a single-arm phase II trial
Sign Up to like & getrecommendations! Published in 2018 at "Cancer Chemotherapy and Pharmacology"
DOI: 10.1007/s00280-018-3650-4
Abstract: PurposeWe conducted a single-arm prospective phase II study to determine the efficacy and safety of the first-line treatment of advanced pancreatic cancer with nab-paclitaxel and S-1 followed by S-1 maintenance therapy.MethodsNab-paclitaxel was administered intravenously on… read more here.
Keywords: first line; maintenance; advanced pancreatic; single arm ... See more keywords
Explanation Within Arm’s Reach: A Predictive Processing Framework for Single Arm Use in Octopuses
Sign Up to like & getrecommendations! Published in 2021 at "Erkenntnis"
DOI: 10.1007/s10670-021-00424-7
Abstract: Octopuses are highly intelligent animals with vertebrate-like cognitive and behavioural repertoires. Despite these similarities, vertebrate-based models of cognition and behaviour cannot always be successfully applied to octopuses, due to the structural and functional characteristics that… read more here.
Keywords: arm; motor; single arm; use ... See more keywords
A Single-Arm, Open-Label, Phase IV Study to Evaluate the Efficacy of a Topical Formulation for Hyperkeratotic Actinic Keratosis Lesions
Sign Up to like & getrecommendations! Published in 2018 at "Dermatology and Therapy"
DOI: 10.1007/s13555-018-0252-3
Abstract: IntroductionActinic keratosis (AKs) are epidermal lesions that commonly occur in skin exposed to chronic cumulative UV irradiation. Untreated AK lesions can advance to squamous cell carcinoma. Current treatments of AK have many shortcomings; for instance,… read more here.
Keywords: arm open; label phase; study; efficacy ... See more keywords
Mid-term absorbable monofilament is safe and effective for gastrointestinal anastomosis – PROMEGAT - A single-arm prospective observational study
Sign Up to like & getrecommendations! Published in 2018 at "Annals of Medicine and Surgery"
DOI: 10.1016/j.amsu.2018.04.003
Abstract: Introduction Various suture materials and suture techniques are used to perform gastrointestinal anastomosis after tumour resection, but the best combination is still a matter of debate. Methods This multi-centre, international, single-arm, prospective observational study aimed… read more here.
Keywords: observational study; suture; anastomosis; single arm ... See more keywords