Cetuximab Rechallenge Plus Avelumab in Pretreated Patients With RAS Wild-type Metastatic Colorectal Cancer: The Phase 2 Single-Arm Clinical CAVE Trial.
Sign Up to like & getrecommendations! Published in 2021 at "JAMA oncology"
DOI: 10.1001/jamaoncol.2021.2915
Abstract: Importance Rechallenge therapy with anti-epidermal growth factor receptor (EGFR) drugs has been suggested in patients with chemo-refractory RAS wild-type (WT) metastatic colorectal cancer (mCRC) after initial response to anti-EGFR-based first-line treatment. The association of treatment… read more here.
Keywords: trial; cetuximab; months months; rechallenge ... See more keywords
Patient‐centered communication tool for older patients with acute myeloid leukemia, their caregivers, and oncologists: A single‐arm pilot study
Sign Up to like & getrecommendations! Published in 2022 at "Cancer Medicine"
DOI: 10.1002/cam4.5547
Abstract: In a single‐arm pilot study, we assessed the feasibility and usefulness of an innovative patient‐centered communication tool (UR‐GOAL tool) that addresses aging‐related vulnerabilities, patient values, and prognostic awareness for use in treatment decision making between… read more here.
Keywords: tool; single arm; arm pilot; patient centered ... See more keywords
Single‐arm trials for US Food and Drug Administration cancer drug approvals
Sign Up to like & getrecommendations! Published in 2023 at "Cancer"
DOI: 10.1002/cncr.34830
Abstract: O ver the past couple of decades, the US Food and Drug Administration (FDA) has increasingly used data from single-arm trials to approve cancer drugs. Of the 563 new oncology drug indications approved by the… read more here.
Keywords: oncology; food drug; single arm; drug ... See more keywords
Adherence to evidence‐based surgical metrics improves outcomes in lung cancer
Sign Up to like & getrecommendations! Published in 2023 at "Cancer"
DOI: 10.1002/cncr.34831
Abstract: 1627 such as progression-free survival or overall survival and are limited in assessing safety. Nevertheless, Dr Agrawal believes that oncologists can have confidence in the approvals based on single-arm studies. “Many approvals based on single-arm… read more here.
Keywords: oncology; approval; arm; single arm ... See more keywords
Nab-paclitaxel plus S-1 as first-line followed by S-1 maintenance for advanced pancreatic adenocarcinoma: a single-arm phase II trial
Sign Up to like & getrecommendations! Published in 2018 at "Cancer Chemotherapy and Pharmacology"
DOI: 10.1007/s00280-018-3650-4
Abstract: PurposeWe conducted a single-arm prospective phase II study to determine the efficacy and safety of the first-line treatment of advanced pancreatic cancer with nab-paclitaxel and S-1 followed by S-1 maintenance therapy.MethodsNab-paclitaxel was administered intravenously on… read more here.
Keywords: first line; maintenance; advanced pancreatic; single arm ... See more keywords
Explanation Within Arm’s Reach: A Predictive Processing Framework for Single Arm Use in Octopuses
Sign Up to like & getrecommendations! Published in 2021 at "Erkenntnis"
DOI: 10.1007/s10670-021-00424-7
Abstract: Octopuses are highly intelligent animals with vertebrate-like cognitive and behavioural repertoires. Despite these similarities, vertebrate-based models of cognition and behaviour cannot always be successfully applied to octopuses, due to the structural and functional characteristics that… read more here.
Keywords: arm; motor; single arm; use ... See more keywords
A Single-Arm, Open-Label, Phase IV Study to Evaluate the Efficacy of a Topical Formulation for Hyperkeratotic Actinic Keratosis Lesions
Sign Up to like & getrecommendations! Published in 2018 at "Dermatology and Therapy"
DOI: 10.1007/s13555-018-0252-3
Abstract: IntroductionActinic keratosis (AKs) are epidermal lesions that commonly occur in skin exposed to chronic cumulative UV irradiation. Untreated AK lesions can advance to squamous cell carcinoma. Current treatments of AK have many shortcomings; for instance,… read more here.
Keywords: arm open; label phase; study; efficacy ... See more keywords
Mid-term absorbable monofilament is safe and effective for gastrointestinal anastomosis – PROMEGAT - A single-arm prospective observational study
Sign Up to like & getrecommendations! Published in 2018 at "Annals of Medicine and Surgery"
DOI: 10.1016/j.amsu.2018.04.003
Abstract: Introduction Various suture materials and suture techniques are used to perform gastrointestinal anastomosis after tumour resection, but the best combination is still a matter of debate. Methods This multi-centre, international, single-arm, prospective observational study aimed… read more here.
Keywords: observational study; suture; anastomosis; single arm ... See more keywords
Intrapatient comparisons of efficacy in a single-arm trial of entrectinib in tumour-agnostic indications
Sign Up to like & getrecommendations! Published in 2021 at "ESMO Open"
DOI: 10.1016/j.esmoop.2021.100072
Abstract: Background Entrectinib is a tropomyosin receptor kinase inhibitor approved for the treatment of neurotrophic tyrosine receptor kinase (NTRK) fusion-positive solid tumours based on single-arm trials. Traditional randomised clinical trials in rare cancers are not feasible;… read more here.
Keywords: entrectinib; analysis; prior therapy; single arm ... See more keywords
A Single-arm, Multicenter, Phase 2 Study of Lenvatinib Plus Everolimus in Patients with Advanced Non-Clear Cell Renal Cell Carcinoma.
Sign Up to like & getrecommendations! Published in 2021 at "European urology"
DOI: 10.1016/j.eururo.2021.03.015
Abstract: BACKGROUND Non-clear cell renal cell carcinoma (nccRCC) accounts for ≤20% of RCC cases. Lenvatinib (a multitargeted tyrosine kinase inhibitor) in combination with everolimus (an mTOR inhibitor) is approved for the treatment of advanced RCC after… read more here.
Keywords: lenvatinib plus; plus everolimus; study; single arm ... See more keywords
From single-arm studies to externally controlled studies. Methodological considerations and guidelines.
Sign Up to like & getrecommendations! Published in 2019 at "Therapie"
DOI: 10.1016/j.therap.2019.11.007
Abstract: Single-arm studies are sometimes used as pivotal studies but they have methodological limitations which prevent them from obtaining the high level of reliability as for a randomised controlled study which remains the gold standard in… read more here.
Keywords: controlled studies; externally controlled; arm studies; single arm ... See more keywords