Conformation Dynamics of Single Polymer Strands in Solution
Sign Up to like & getrecommendations! Published in 2022 at "Advanced Materials"
DOI: 10.1002/adma.202202353
Abstract: Conformational changes in macromolecules significantly affect their functions and assembly into high‐level structures. Despite advances in theoretical and experimental studies, investigations into the intrinsic conformational variations and dynamic motions of single macromolecules remain challenging. Here,… read more here.
Keywords: dynamics single; polymer; single polymer; single chain ... See more keywords
Synthesis of single‐chain antibody fragment fused to the elastin‐like polypeptide in Nicotiana benthamiana and its application in affinity precipitation of difficult to produce proteins
Sign Up to like & getrecommendations! Published in 2022 at "Biotechnology and Bioengineering"
DOI: 10.1002/bit.28158
Abstract: Plants are economical and sustainable factories for the production of recombinant proteins. Currently, numerous proteins produced using different plant‐based systems with applications as cosmetic and tissue culture ingredients, research and diagnostic reagents, and industrial enzymes… read more here.
Keywords: elp; elastin like; single chain; chain antibody ... See more keywords
Bacterially Secretable Single‐Chain Tandem Macrocyclic Peptides for High Affinity and Inhibitory Activity
Sign Up to like & getrecommendations! Published in 2022 at "ChemBioChem"
DOI: 10.1002/cbic.202200599
Abstract: The inhibition of protein‐protein interactions (PPIs) is an effective approach for therapy. Owing to their large binding surface areas to target proteins, macrocyclic peptides are suitable molecules for PPI inhibition. In this study, we developed… read more here.
Keywords: chain tandem; macrocyclic peptides; inhibitory activity; single chain ... See more keywords
Optimized Anti–Prostate‐Specific Membrane Antigen Single‐Chain Variable Fragment–Loaded Nanobubbles as a Novel Targeted Ultrasound Contrast Agent for the Diagnosis of Prostate Cancer
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Ultrasound in Medicine"
DOI: 10.1002/jum.15155
Abstract: To prepare optimized prostate‐specific membrane antigen (PSMA) single‐chain variable fragment (scFv)–loaded nanobubbles (NBs) as a novel targeted ultrasound (US) contrast agent for diagnosis and treatment of prostate cancer (PCa). read more here.
Keywords: prostate; prostate specific; specific membrane; chain variable ... See more keywords
Facile Access to Completely Deuterated Single-Chain Nanoparticles Enabled by Intramolecular Azide Photodecomposition.
Sign Up to like & getrecommendations! Published in 2019 at "Macromolecular rapid communications"
DOI: 10.1002/marc.201900046
Abstract: Access to completely deuterated single-chain nanoparticles (dSCNPs) has remained an unresolved issue. Herein, the first facile and efficient procedure to produce dSCNPs is reported, which comprises: i) the use of commercially available perdeuterated cyclic ether… read more here.
Keywords: completely deuterated; access completely; deuterated single; chain nanoparticles ... See more keywords
Solvent Remodeling in Single-Chain Amphiphilic Heteropolymer Systems.
Sign Up to like & getrecommendations! Published in 2022 at "Macromolecular rapid communications"
DOI: 10.1002/marc.202200142
Abstract: This work demonstrates the remodeling of single-chain nanoparticles (SCNPs) upon a transition to organic solvent through molecular dynamics simulations. Methacrylate-based random heteropolymers (RHPs), assembled via transient non-covalent linkages in water, have shown promise in an… read more here.
Keywords: amphiphilic heteropolymer; solvent remodeling; single chain; chain amphiphilic ... See more keywords
Tuning the Internal Compartmentation of Single-Chain Nanoparticles as Fluorescent Contrast Agents.
Sign Up to like & getrecommendations! Published in 2022 at "Macromolecular rapid communications"
DOI: 10.1002/marc.202200618
Abstract: Controlling the internal structures of single-chain nanoparticles (SCNPs) is an important factor for their targeted chemical design and synthesis, especially in view of nanosized compartments presenting different local environments as a main feature to embed… read more here.
Keywords: contrast agents; chain nanoparticles; single chain; tuning internal ... See more keywords
A Poly(Propyleneimine) Dendrimer-Based Polyplex-System for Single-Chain Antibody-Mediated Targeted Delivery and Cellular Uptake of SiRNA.
Sign Up to like & getrecommendations! Published in 2017 at "Small"
DOI: 10.1002/smll.201700072
Abstract: Therapeutics based on small interfering RNAs (siRNAs) offer a great potential to treat so far incurable diseases or metastatic cancer. However, the broad application of siRNAs using various nonviral carrier systems is hampered by unspecific… read more here.
Keywords: system; delivery; single chain; poly propyleneimine ... See more keywords
Bovine single chain Fv antibody inhibits bovine herpesvirus-1 infectivity by targeting viral glycoprotein D
Sign Up to like & getrecommendations! Published in 2017 at "Applied Microbiology and Biotechnology"
DOI: 10.1007/s00253-017-8566-0
Abstract: Glycoprotein D (gD) of bovine herpesvirus-1 (BoHV-1) is essential for attachment and penetration of cells during infection and is a major target for neutralizing antibodies during an adaptive immune response. Currently there are no recombinant… read more here.
Keywords: chain antibody; bovine; bovine herpesvirus; bohv ... See more keywords
Construction and characterization of a class-specific single-chain variable fragment against pyrethroid metabolites
Sign Up to like & getrecommendations! Published in 2020 at "Applied Microbiology and Biotechnology"
DOI: 10.1007/s00253-020-10728-3
Abstract: Pyrethroids are insecticides that are widely used in rural and urban areas worldwide. After entering the environment, pyrethroids are rapidly metabolized or degraded by various biological or abiotic methods. In this study, a single-chain variable… read more here.
Keywords: pyrethroid metabolites; scfv; chain variable; variable fragment ... See more keywords
Production and Characterization of Single Chain Nimotuzumab: An In Vitro Study
Sign Up to like & getrecommendations! Published in 2017 at "International Journal of Peptide Research and Therapeutics"
DOI: 10.1007/s10989-017-9603-7
Abstract: Recombinant expression and EGFR-binding activity assay of single chain nimotuzumab (nimotuzumab scFv) is reported in this study. The scFv was produced in VH-linker-VL format in Origami™ 2(DE3)pLysS bacterial cells and purified using Ni-TNA resin column.… read more here.
Keywords: chain; chain nimotuzumab; study; production characterization ... See more keywords