Super‐killer CTLs are generated by single gene deletion of Bach2
Sign Up to like & getrecommendations! Published in 2022 at "European Journal of Immunology"
DOI: 10.1002/eji.202249797
Abstract: Bach2 codes for a transcriptional regulator exerting major influences on T cell‐mediated immune regulation. Effector CTLs derived from in vitro activation of murine CD8+ T cells showed increased proliferative and cytolytic capacity in the absence… read more here.
Keywords: ctls; bach2; super killer; gene deletion ... See more keywords
Targeted Single Gene Mutation in Esophageal Adenocarcinoma.
Sign Up to like & getrecommendations! Published in 2018 at "Methods in molecular biology"
DOI: 10.1007/978-1-4939-7734-5_19
Abstract: Esophageal adenocarcinoma is heterogeneous and studies have reviewed many important mutations that contribute to the pathogenesis of the cancer. These discoveries have helped paved the way into identifying new gene markers or gene targets to… read more here.
Keywords: single gene; targeted single; esophageal adenocarcinoma; gene mutation ... See more keywords
IPSC-Derived Neurons Harboring a Known Epilepsy Mutation Display Known and Novel Electrophysiological Phenotypes
Sign Up to like & getrecommendations! Published in 2017 at "Biophysical Journal"
DOI: 10.1016/j.bpj.2016.11.2954
Abstract: Epilepsy is a disturbance in the electrical activity of the brain manifested via countless etiologies. 65 million individuals suffer from epilepsy and one-third of these individuals live with uncontrollable seizures because no known pharmacological treatment… read more here.
Keywords: medicine; neurons harboring; single gene; ipsc derived ... See more keywords
Sex chromosomes-linked single-gene disorders involved in human infertility.
Sign Up to like & getrecommendations! Published in 2018 at "European journal of medical genetics"
DOI: 10.1016/j.ejmg.2018.10.012
Abstract: Human infertility is a healthcare problem that has a worldwide impact. Genetic causes of human infertility include chromosomal aneuploidies and rearrangements and single-gene defects. The sex chromosomes (X and Y) are critical players in human… read more here.
Keywords: infertility; sex chromosomes; human infertility; single gene ... See more keywords
Two structures from a single gene: investigating the differential folding of SOD3
Sign Up to like & getrecommendations! Published in 2018 at "Free Radical Biology and Medicine"
DOI: 10.1016/j.freeradbiomed.2018.10.117
Abstract: Extracellular superoxide dismutase (SOD3) is a zinc and copper-containing enzyme that is responsible for the dismutation of the reactive oxygen species superoxide. SOD3 has previously been shown to exist in two distinct folding variants. These… read more here.
Keywords: two structures; single gene; folding variants; sod3 ... See more keywords
Clinical validation of combinatorial pharmacogenomic testing and single-gene guidelines in predicting psychotropic medication blood levels and clinical outcomes in patients with depression
Sign Up to like & getrecommendations! Published in 2021 at "Psychiatry Research"
DOI: 10.1016/j.psychres.2020.113649
Abstract: We evaluated the clinical validity of a combinatorial pharmacogenomic test and single-gene Clinical Pharmacogenetics Implementation Consortium (CPIC) guidelines against patient outcomes and medication blood levels to assess their ability to inform prescribing in major depressive… read more here.
Keywords: single gene; combinatorial pharmacogenomic; gene guidelines; blood levels ... See more keywords
Single-gene regulated non-spore-forming Bacillus subtilis: Construction, transcriptome responses and applications for producing enzymes and surfactin.
Sign Up to like & getrecommendations! Published in 2020 at "Metabolic engineering"
DOI: 10.1016/j.ymben.2020.08.008
Abstract: Bacillus subtilis, a spore-forming industrial bacteria, is widely used for enzymes and valuable chemicals production. The spore-formation, however, always results in remarkably reduced cell-density, thereby reduced product-yield. Here, we construct different patterns of non-spore-forming B.… read more here.
Keywords: bacillus subtilis; spore forming; single gene; non spore ... See more keywords
SlMYB75, an MYB-type transcription factor, promotes anthocyanin accumulation and enhances volatile aroma production in tomato fruits
Sign Up to like & getrecommendations! Published in 2019 at "Horticulture Research"
DOI: 10.1038/s41438-018-0098-y
Abstract: Genetic manipulation of genes to upregulate specific branches of metabolic pathways is a method that is commonly used to improve fruit quality. However, the use of a single gene to impact several metabolic pathways is… read more here.
Keywords: quality; production; slmyb75; fruit quality ... See more keywords
Single gene analysis in yeast suggests nonequilibrium regulatory dynamics for transcription
Sign Up to like & getrecommendations! Published in 2024 at "Nature Communications"
DOI: 10.1038/s41467-024-50419-5
Abstract: Fluctuations in the initiation rate of transcription, the first step in gene expression, ensue from the stochastic behavior of the molecular process that controls transcription. In steady state, the regulatory process is often assumed to… read more here.
Keywords: single gene; yeast; regulatory process; gene ... See more keywords
Clinical impact of single-gene vs. panel sequencing in advanced HR + /HER2− breast cancer: insights and implications
Sign Up to like & getrecommendations! Published in 2025 at "NPJ Breast Cancer"
DOI: 10.1038/s41523-025-00805-z
Abstract: Hormone receptor-positive (HR + )/HER2−negative (HER2 − ) breast cancer is the most common subtype, with biomarker-driven therapies improving outcomes. Circulating tumor DNA (ctDNA) analysis enables minimally invasive assessment of somatic alterations to guide therapy. However, assay choice impacts… read more here.
Keywords: her2 breast; her2; breast cancer; single gene ... See more keywords
Reflex single-gene non-invasive prenatal testing is associated with markedly better detection of fetuses affected with single-gene recessive disorders at lower cost
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Medical Economics"
DOI: 10.1080/13696998.2022.2053384
Abstract: Abstract Objective To evaluate the clinical benefits and achievable cost savings associated with the adoption of a carrier screen with reflex single-gene non-invasive prenatal test (sgNIPT) in prenatal care. Method A decision-analytic model was developed… read more here.
Keywords: cost; reflex sgnipt; carrier; single gene ... See more keywords