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Published in 2022 at "Cancer research"
DOI: 10.1158/0008-5472.can-21-3458
Abstract: Cancer-related genes are under intense evolutionary pressure. In this study, we conjecture that X-linked tumor suppressor genes (TSG) are not protected by the Knudson's two-hit mechanism and are therefore subject to negative selection. Accordingly, nearly…
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Keywords:
suppressor genes;
single hit;
tumor suppressor;
hit inactivation ... See more keywords