Single-hit genome editing optimized for maturation in B cells redirects their specificity toward tumor antigens
Sign Up to like & getrecommendations! Published in 2024 at "Scientific Reports"
DOI: 10.1038/s41598-024-74005-3
Abstract: T-cell-based adoptive immunotherapy is a new pillar of cancer care. Tumor-redirected B cells could also contribute to therapy if their manipulation to rewire immunoglobulin (Ig) genes is mastered. We designed a single-chain Ig-encoding cassette (“scFull-Ig”)… read more here.
Keywords: single hit; specificity; tumor; cell ... See more keywords
Single-hit inactivation drove tumor suppressor genes out of the X chromosome during evolution.
Sign Up to like & getrecommendations! Published in 2022 at "Cancer research"
DOI: 10.1158/0008-5472.can-21-3458
Abstract: Cancer-related genes are under intense evolutionary pressure. In this study, we conjecture that X-linked tumor suppressor genes (TSG) are not protected by the Knudson's two-hit mechanism and are therefore subject to negative selection. Accordingly, nearly… read more here.
Keywords: suppressor genes; single hit; tumor suppressor; hit inactivation ... See more keywords
Impact of TP53 Mutation on Outcome after Allogeneic Stem Cell Transplantation for Patients with MDS/AML Not in Complete Remission
Sign Up to like & getrecommendations! Published in 2024 at "Blood"
DOI: 10.1182/blood-2024-205849
Abstract: Introduction: The TP53-mutated MDS/AML patients have a dismal prognosis. Even after allo-SCT, the long-term survival remains low, which raises the question of whether these patients should be considered as potential candidates for this approach. Further,… read more here.
Keywords: single hit; tp53 mutation; mds aml; mutation ... See more keywords