Induction of resistance to chimeric antigen receptor T cell therapy by transduction of a single leukemic B cell
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DOI: 10.1038/s41591-018-0201-9
Abstract: We report a patient relapsing 9 months after CD19-targeted CAR T cell (CTL019) infusion with CD19– leukemia that aberrantly expressed the anti-CD19 CAR. The CAR gene was unintentionally introduced into a single leukemic B cell… read more here.
Keywords: leukemic cell; resistance; therapy; cell ... See more keywords