A microfluidic device for isolating intact chromosomes from single mammalian cells and probing their folding stability by controlling solution conditions
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DOI: 10.1038/s41598-018-31975-5
Abstract: Chromatin folding shows spatio-temporal fluctuations in living undifferentiated cells, but fixed spatial heterogeneity in differentiated cells. However, little is known about variation in folding stability along the chromatin fibres during differentiation. In addition, effective methods… read more here.
Keywords: folding stability; single mammalian; microfluidic device; chromosomes single ... See more keywords