Kupffer Cell and Hepatocyte Isolation from a Single Mouse Liver by Gradient Centrifugation.
Sign Up to like & getrecommendations! Published in 2020 at "Methods in molecular biology"
DOI: 10.1007/978-1-0716-0704-6_1
Abstract: Kupffer cells and hepatocytes maintain liver homeostasis. These cells could be separated based on their size and weight, by centrifugation using a density gradient after a liver perfusion. Here, we describe a methodology to isolate… read more here.
Keywords: single mouse; kupffer; liver; centrifugation ... See more keywords
Functional neuropathology of neonatal hypoxia‐ischemia by single‐mouse longitudinal electroencephalography
Sign Up to like & getrecommendations! Published in 2022 at "Epilepsia"
DOI: 10.1111/epi.17403
Abstract: Neonatal cerebral hypoxia‐ischemia (HI) results in symptomatic seizures and long‐term neurodevelopmental disability. The Rice‐Vannucci model of rodent neonatal HI has been used extensively to examine and translate the functional consequences of acute and chronic HI‐induced… read more here.
Keywords: single mouse; hypoxia ischemia; mouse; electroencephalography ... See more keywords
Abstract 4815: Humanized single mouse trial: A preclinical platform feasible for immune-oncology drug screening and translational biomarker development
Sign Up to like & getrecommendations! Published in 2017 at "Cancer Research"
DOI: 10.1158/1538-7445.am2017-4815
Abstract: The field of cancer immunology is rapidly moving towards innovative therapeutic strategies. As a consequence the need for robust and predictive preclinical platforms arises just as well. The current project aims to establish a drug… read more here.
Keywords: treatment; single mouse; drug screening; biomarker development ... See more keywords
Abstract 3524: Pharmacological characterization of pediatric brain tumor PDX models in a single mouse trial format
Sign Up to like & getrecommendations! Published in 2023 at "Cancer Research"
DOI: 10.1158/1538-7445.am2023-3524
Abstract: Cancer remains the leading cause of disease-related death in children. Preclinical drug testing to identify promising treatment options for relapsed patients or those with poor prognosis is hindered by the lack of well characterized and… read more here.
Keywords: pediatric brain; tumor; single mouse; brain ... See more keywords
A Single Mouse Trial Platform for Evaluation of Novel Agents in Acute Lymphoblastic Leukemia By the Pediatric Preclinical Testing Consortium
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DOI: 10.1182/blood-2018-99-113207
Abstract: Introduction: While children diagnosed with the most common pediatric malignancy, acute lymphoblastic leukemia (ALL), now experience close to a 90% likelihood of cure, the outcome for several high-risk subtypes remains poor. Furthermore, since standard-of-care drugs… read more here.
Keywords: trial; response; preclinical testing; single mouse ... See more keywords