Single-Nephron GFR in Patients With Obesity-Related Glomerulopathy
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DOI: 10.1016/j.ekir.2020.05.013
Abstract: Introduction Obesity-related glomerulopathy (ORG) is a slowly progressive kidney disease occurring in association with obesity. It is characterized histopathologically by glomerulomegaly, likely caused by single-nephron hyperfiltration that has not been demonstrated in humans because of… read more here.
Keywords: single nephron; related glomerulopathy; obesity related; nephron ... See more keywords
Single-nephron proteomes connect morphology and function in proteinuric kidney disease.
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DOI: 10.1016/j.kint.2017.12.012
Abstract: In diseases of many parenchymatous organs, heterogeneous deterioration of individual functional units determines the clinical prognosis. However, the molecular characterization at the level of such individual subunits remains a technological challenge that needs to be… read more here.
Keywords: kidney; single nephron; disease single; proteinuric kidney ... See more keywords
A new analysis approach for single nephron GFR in intravital microscopy of mice
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DOI: 10.12688/f1000research.26888.3
Abstract: Background: Intravital microscopy is an emerging technique in life science with applications in kidney research. Longitudinal observation of (patho-)physiological processes in living mice is possible in the smallest functional unit of the kidney, a single… read more here.
Keywords: single nephron; microscopy; analysis; intravital microscopy ... See more keywords