Disentangling glial diversity in peripheral nerves at single-nuclei resolution.
Sign Up to like & getrecommendations! Published in 2022 at "Nature neuroscience"
DOI: 10.1038/s41593-021-01005-1
Abstract: The peripheral nerve contains diverse cell types that support its proper function and maintenance. In this study, we analyzed multiple peripheral nerves using single-nuclei RNA sequencing, which allowed us to circumvent difficulties encountered in analyzing… read more here.
Keywords: diversity; single nuclei; peripheral nerve; cell types ... See more keywords
Single-nuclei RNA sequencing (snRNA-seq) uncovers trophoblast cell types and lineages in the mature bovine placenta.
Sign Up to like & getrecommendations! Published in 2023 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.2221526120
Abstract: Ruminants have a semi-invasive placenta, which possess highly vascularized placentomes formed by maternal endometrial caruncles and fetal placental cotyledons and required for fetal development to term. The synepitheliochorial placenta of cattle contains at least two… read more here.
Keywords: cell; trophoblast cell; cell types; placenta ... See more keywords
The nesprin-cytoskeleton interface probed directly on single nuclei is a mechanically rich system
Sign Up to like & getrecommendations! Published in 2017 at "Nucleus"
DOI: 10.1080/19491034.2017.1322237
Abstract: ABSTRACT The cytoskeleton provides structure and plays an important role in cellular function such as migration, resisting compression forces, and transport. The cytoskeleton also reacts to physical cues such as fluid shear stress or extracellular… read more here.
Keywords: cytoskeleton; interface probed; nesprin cytoskeleton; cytoskeleton interface ... See more keywords
EPCO-20. RELATING GLIOBLASTOMA HETEROGENEITY TO HUMAN FETAL GLIAL DEVELOPMENT THROUGH HIGH RESOLUTION SINGLE NUCLEI TRANSCRIPTOMICS
Sign Up to like & getrecommendations! Published in 2020 at "Neuro-oncology"
DOI: 10.1093/neuonc/noaa215.299
Abstract: Glioblastoma (GBM) is thought to be driven by a therapy-resistant cancer stem cell population that recapitulates developmental phenotypes. Direct comparisons of GBM to glial states during human fetal development are limited due to paucity of… read more here.
Keywords: resolution; nuclei; gbm; human fetal ... See more keywords
ATRT-28. SINGLE NUCLEI SEQUENCING REVEALS THE DIFFERENT PHENOTYPIC COMPOSITION OF THE ATRT SUBGROUPS
Sign Up to like & getrecommendations! Published in 2020 at "Neuro-Oncology"
DOI: 10.1093/neuonc/noaa222.027
Abstract: Abstract Atypical teratoid/rhabdoid tumors (ATRT) represents a genomically homogeneous disease characterized by loss of SMARCB1 protein in the vast majority of cases. In recent years, it has become clear that these tumors display a high… read more here.
Keywords: atrt; nuclei sequencing; phenotypic composition; single nuclei ... See more keywords
Single-cell and single-nuclei RNA sequencing as powerful tools to decipher cellular heterogeneity and dysregulation in neurodegenerative diseases
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Cell and Developmental Biology"
DOI: 10.3389/fcell.2022.884748
Abstract: Neurodegenerative diseases affect millions of people worldwide and there are currently no cures. Two types of common neurodegenerative diseases are Alzheimer’s (AD) and Parkinson’s disease (PD). Single-cell and single-nuclei RNA sequencing (scRNA-seq and snRNA-seq) have… read more here.
Keywords: cell; cell single; single cell; nuclei rna ... See more keywords
Single nuclei RNA sequencing investigation of the Purkinje cell and glial changes in the cerebellum of transgenic Spinocerebellar ataxia type 1 mice
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Cellular Neuroscience"
DOI: 10.3389/fncel.2022.998408
Abstract: Glial cells constitute half the population of the human brain and are essential for normal brain function. Most, if not all, brain diseases are characterized by reactive gliosis, a process by which glial cells respond… read more here.
Keywords: ataxia type; purkinje; purkinje cells; spinocerebellar ataxia ... See more keywords
Disentangling glial diversity in peripheral nerves at single-nuclei resolution
Sign Up to like & getrecommendations! Published in 2022 at "Nature Neuroscience"
DOI: 10.7936/d9jw-sr89
Abstract: The peripheral nerve contains diverse cell types that support its proper function and maintenance. In this study, we analyzed multiple peripheral nerves using single-nuclei RNA sequencing, which allowed us to circumvent difficulties encountered in analyzing… read more here.
Keywords: peripheral nerves; cell types; peripheral nerve; diversity ... See more keywords