Association of Single-Nucleotide Variants in the Human Leukocyte Antigen and Other Loci With Childhood Hodgkin Lymphoma
Sign Up to like & getrecommendations! Published in 2022 at "JAMA Network Open"
DOI: 10.1001/jamanetworkopen.2022.25647
Abstract: Key Points Question What genetic variants or genes are associated with the risk of childhood Hodgkin lymphoma? Findings In this genetic association study nested within 3 childhood cancer survivor cohorts, 3 independent single-nucleotide variants (SNVs,… read more here.
Keywords: nucleotide variants; hodgkin lymphoma; childhood; single nucleotide ... See more keywords
Genome‐Wide 3′‐UTR Single Nucleotide Polymorphism Association Study Identifies Significant Prostate Cancer Risk‐Associated Functional Loci at 8p21.2 in Chinese Population
Sign Up to like & getrecommendations! Published in 2022 at "Advanced Science"
DOI: 10.1002/advs.202201420
Abstract: MicroRNAs (miRNAs) are involved in the regulation of gene expression via incomplete base pairing to sequence motifs at the three prime untranslated regions (3′‐UTRs) of mRNAs and play critical roles in the etiology of cancers.… read more here.
Keywords: prostate cancer; genome wide; association study; single nucleotide ... See more keywords
The association between single nucleotide polymorphisms and ovarian cancer risk: A systematic review and network meta‐analysis
Sign Up to like & getrecommendations! Published in 2022 at "Cancer Medicine"
DOI: 10.1002/cam4.4891
Abstract: The relationship between single nucleotide polymorphisms (SNPs) and ovarian cancer (OC) risk remains controversial. This systematic review and network meta‐analysis was aimed to determine the association between SNPs and OC risk. read more here.
Keywords: nucleotide polymorphisms; ovarian cancer; single nucleotide; risk ... See more keywords
Association between a single nucleotide polymorphism in the R3HCC1 gene and irinotecan toxicity
Sign Up to like & getrecommendations! Published in 2022 at "Cancer Medicine"
DOI: 10.1002/cam4.5299
Abstract: Irinotecan is a useful anticancer drug for colorectal cancer treatment. UGT1A1*28 and *6 gene polymorphisms are known risk factors for irinotecan‐associated toxicity. However, severe adverse effects due to irinotecan have been observed even in patients… read more here.
Keywords: irinotecan toxicity; nucleotide polymorphism; toxicity; single nucleotide ... See more keywords
Serum IL‐17A concentration and a IL17RA single nucleotide polymorphism contribute to the risk of autoimmune type 1 diabetes
Sign Up to like & getrecommendations! Published in 2022 at "Diabetes/Metabolism Research and Reviews"
DOI: 10.1002/dmrr.3547
Abstract: Interleukin (IL)‐17 is associated with autoimmunity. This study aimed to affirm the role of IL‐17A, IL‐17F and single nucleotide polymorphisms (SNPs) in genes related to them and their receptors in autoimmune type 1 diabetes (T1D)… read more here.
Keywords: autoimmune type; serum 17a; single nucleotide; 17a concentration ... See more keywords
Simple Visualization Method for the c.577del of Erythropoietin Variant: CRISPR/dCas9 based Single Nucleotide Polymorphism Diagnosis.
Sign Up to like & getrecommendations! Published in 2023 at "Drug testing and analysis"
DOI: 10.1002/dta.3438
Abstract: One of the single nucleotide polymorphisms (SNPs) in human erythropoietin (hEPO), the c.577del variant, can produces 26 amino acids longer than the wild-type hEPO, posing a risk of misinterpretation in routine doping analysis. To prevent… read more here.
Keywords: method 577del; visualization method; single nucleotide; erythropoietin ... See more keywords
Single nucleotide editing without DNA cleavage using CRISPR/Cas9‐deaminase in the sea urchin embryo
Sign Up to like & getrecommendations! Published in 2017 at "Developmental Dynamics"
DOI: 10.1002/dvdy.24586
Abstract: Background: A single base pair mutation in the genome can result in many congenital disorders in humans. The recent gene editing approach using CRISPR/Cas9 has rapidly become a powerful tool to replicate or repair such… read more here.
Keywords: crispr cas9; single nucleotide; nucleotide editing; sea urchin ... See more keywords
Single nucleotide polymorphism barcoding of cytochrome c oxidase I sequences for discriminating 17 species of Columbidae by decision tree algorithm
Sign Up to like & getrecommendations! Published in 2017 at "Ecology and Evolution"
DOI: 10.1002/ece3.3045
Abstract: Abstract DNA barcodes are widely used in taxonomy, systematics, species identification, food safety, and forensic science. Most of the conventional DNA barcode sequences contain the whole information of a given barcoding gene. Most of the… read more here.
Keywords: decision; tree; single nucleotide; nucleotide polymorphism ... See more keywords
Nanopore label‐free detection of single‐nucleotide deletion in Baxα/BaxΔ2
Sign Up to like & getrecommendations! Published in 2018 at "ELECTROPHORESIS"
DOI: 10.1002/elps.201800193
Abstract: Baxα, a key tumor suppressor gene, will not be expressed correctly as a result of single nucleotide mutation in its microsatellite region; Instead, BaxΔ2, an isoform of Baxα, is often produced. In addition, lack of… read more here.
Keywords: bax; single nucleotide; label free; detection single ... See more keywords
Potential role of FKBP5 single‐nucleotide polymorphisms in functional seizures
Sign Up to like & getrecommendations! Published in 2023 at "Epilepsia Open"
DOI: 10.1002/epi4.12716
Abstract: We investigated the associations between FKBP5 single‐nucleotide polymorphisms (SNPs) and functional seizures (FS). read more here.
Keywords: nucleotide polymorphisms; single nucleotide; fkbp5 single; functional seizures ... See more keywords
Splicing variant profiles and single nucleotide polymorphisms of the glucocorticoid receptor gene in relation to glucocorticoid sensitivity of B‐cell precursor acute lymphoblastic leukaemia
Sign Up to like & getrecommendations! Published in 2018 at "Hematological Oncology"
DOI: 10.1002/hon.2471
Abstract: Glucocorticoid (GC) shows antileukaemic activity via binding to the GC receptor (GR). The human GR gene has 4 splicing variants besides the functional isoform GRα, but their significance in GC sensitivity of acute lymphoblastic leukaemia… read more here.
Keywords: single nucleotide; sensitivity; lymphoblastic leukaemia; acute lymphoblastic ... See more keywords