How long does a single oral dose of cannabidiol persist in plasma? Findings from three clinical trials.
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DOI: 10.1002/dta.3419
Abstract: A growing number of clinical trials (CTs) are investigating the therapeutic potential of cannabidiol (CBD), a non-intoxicating phytocannabinoid found in Cannabis sativa. These CTs often use crossover experimental designs requiring 'washout' (clearance) periods. However, the… read more here.
Keywords: clinical trials; persist plasma; cbd; single oral ... See more keywords
Effects of repeated oral doses of ketoconazole on a sequential ascending single oral dose of fedratinib in healthy subjects
Sign Up to like & getrecommendations! Published in 2020 at "Cancer Chemotherapy and Pharmacology"
DOI: 10.1007/s00280-020-04067-3
Abstract: Purpose Fedratinib is an orally administered Janus kinase 2-selective inhibitor that is indicated for the treatment of adult patients with intermediate-2 or high-risk myelofibrosis in the United States. Fedratinib is metabolized by multiple cytochrome P450s… read more here.
Keywords: fedratinib; oral doses; oral dose; dose fedratinib ... See more keywords
Absolute Bioavailability of Esaxerenone and Food Effects on its Pharmacokinetics After a Single Oral Dose in Healthy Japanese Subjects: An Open-Label Crossover Study
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DOI: 10.1007/s12325-019-00956-z
Abstract: IntroductionTo investigate the absolute bioavailability of esaxerenone and the effects of food on its pharmacokinetics (PK) after a single oral dose in healthy Japanese subjects.MethodsTwenty-four Japanese males aged 20–45 years were randomised to six groups (each… read more here.
Keywords: esaxerenone; oral dose; absolute bioavailability; single oral ... See more keywords
Pharmacokinetics and pharmacokinetic/pharmacodynamic relationship of vicagrel, a novel thienopyridine P2Y12 inhibitor, compared with clopidogrel in healthy Chinese subjects following single oral dosing
Sign Up to like & getrecommendations! Published in 2019 at "European Journal of Pharmaceutical Sciences"
DOI: 10.1016/j.ejps.2018.10.011
Abstract: Background and objectives Vicagrel, a novel thienopyridine antiplatelet agent, is an analogue of clopidogrel in development for the treatment of acute coronary syndromes. This study investigated the pharmacokinetic properties of vicagrel after single oral dosing… read more here.
Keywords: healthy chinese; clopidogrel; vicagrel; compared clopidogrel ... See more keywords
0500 Evaluation of the Human Abuse Potential of Single Oral Doses of V117957, a Novel, Highly Potent and Selective Partial Agonist for Nociceptin/Orphanin-FQ Peptide (NOP) Receptors
Sign Up to like & getrecommendations! Published in 2020 at "Sleep"
DOI: 10.1093/sleep/zsaa056.497
Abstract: The satisfactory safety/tolerability profile of V117957, an investigational NOP receptor partial agonist, has been previously established in ~200 healthy subjects with maximum doses at 30mg following a single oral administration and 10mg once daily for… read more here.
Keywords: abuse potential; v117957 1mg; placebo; partial agonist ... See more keywords
Thorough QT Study To Evaluate the Effect of Zoliflodacin, a Novel Therapeutic for Gonorrhea, on Cardiac Repolarization in Healthy Adults
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DOI: 10.1128/aac.01292-21
Abstract: Zoliflodacin is a novel spiropyrimidinetrione antibiotic being developed as single oral dose treatment to address the growing global threat of Neisseria gonorrhoeae. To evaluate the cardiac safety of zoliflodacin, a thorough QT/QTc (TQT) study was… read more here.
Keywords: oral dose; study; zoliflodacin; zoliflodacin novel ... See more keywords
High Resolution Free Triiodothyronine-Thyrotropin (FT3-TSH) Responses to a Single Oral Dose of Liothyronine in Humans: Evidence of Distinct Inter-Individual Differences Unraveled Using an Electrical Network Model.
Sign Up to like & getrecommendations! Published in 2017 at "Journal of biological systems"
DOI: 10.1142/s0218339017500073
Abstract: The effects of a single oral dose of liothyronine (L-T3) on thyroid stimulating hormone (TSH) and other related thyroid system parameters are partly understood despite therapeutic use of this hormone over many decades. We characterize… read more here.
Keywords: using electrical; oral dose; model; dose liothyronine ... See more keywords
Single oral or intravenous administration of voriconazole achieved recommended therapeutic minimum inhibitory concentrations against Aspergillus in the common raven (Corvus corax).
Sign Up to like & getrecommendations! Published in 2022 at "American journal of veterinary research"
DOI: 10.2460/ajvr.22.03.0055
Abstract: OBJECTIVE To determine the pharmacokinetics of voriconazole after single IV or orally administered boluses in common ravens (Corvus corax). ANIMALS 8 healthy common ravens. PROCEDURES Voriconazole (5 mg/mL, 10 mg/kg IV) was administered to 8… read more here.
Keywords: single oral; administration; voriconazole achieved; corvus corax ... See more keywords
A Single Oral Dose of Diclofenac Causes Transition of Experimental Subclinical Acute Kidney Injury to Chronic Kidney Disease
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DOI: 10.3390/biomedicines10051198
Abstract: Nephrotoxic drugs can cause acute kidney injury (AKI) and analgesic nephropathy. Diclofenac is potentially nephrotoxic and frequently prescribed for pain control. In this study, we investigated the effects of single and repetitive oral doses of… read more here.
Keywords: aki; kidney; dose; single oral ... See more keywords
Toxicokinetics of a Single Oral Dose of OTA on Dezhou Male Donkeys
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DOI: 10.3390/toxins15020088
Abstract: Ochratoxin (OTA) is widely present in a wide range of foods and feeds, causing adverse effects on animals and humans. This study aims to explore the toxicokinetics of OTA-contaminated materials on the Dezhou male donkey.… read more here.
Keywords: dezhou male; ota; toxicokinetics single; single oral ... See more keywords
Impact of a Single Oral Acute Dose of Aflatoxin B1 on Liver Function/Cytokines and the Lymphoproliferative Response in C57Bl/6 Mice
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DOI: 10.3390/toxins9110374
Abstract: Aflatoxin B1 (AFB1), a mycotoxin found in food and feed, exerts harmful effects on humans and animals. The liver is the earliest target of AFB1, and its effects have been evaluated in animal models exposed… read more here.
Keywords: liver function; afb1; lymphoproliferative response; mice ... See more keywords