How long does a single oral dose of cannabidiol persist in plasma? Findings from three clinical trials.
Sign Up to like & getrecommendations! Published in 2022 at "Drug testing and analysis"
DOI: 10.1002/dta.3419
Abstract: A growing number of clinical trials (CTs) are investigating the therapeutic potential of cannabidiol (CBD), a non-intoxicating phytocannabinoid found in Cannabis sativa. These CTs often use crossover experimental designs requiring 'washout' (clearance) periods. However, the… read more here.
Keywords: clinical trials; persist plasma; cbd; single oral ... See more keywords
Pharmacokinetics of Milbemycin Oxime in Pekingese Dogs after Single Oral and Intravenous Administration
Sign Up to like & getrecommendations! Published in 2025 at "Veterinary Medicine and Science"
DOI: 10.1002/vms3.70312
Abstract: ABSTRACT Objective This study aimed to characterize the pharmacokinetic profiles of milbemycin oxime in Pekingese dogs following a single oral (PO) and intravenous (IV) dose. Six clinically healthy Pekingese dogs, with an average body weight… read more here.
Keywords: milbemycin oxime; pekingese dogs; administration; single oral ... See more keywords
Effects of repeated oral doses of ketoconazole on a sequential ascending single oral dose of fedratinib in healthy subjects
Sign Up to like & getrecommendations! Published in 2020 at "Cancer Chemotherapy and Pharmacology"
DOI: 10.1007/s00280-020-04067-3
Abstract: Purpose Fedratinib is an orally administered Janus kinase 2-selective inhibitor that is indicated for the treatment of adult patients with intermediate-2 or high-risk myelofibrosis in the United States. Fedratinib is metabolized by multiple cytochrome P450s… read more here.
Keywords: fedratinib; oral doses; oral dose; dose fedratinib ... See more keywords
Absolute Bioavailability of Esaxerenone and Food Effects on its Pharmacokinetics After a Single Oral Dose in Healthy Japanese Subjects: An Open-Label Crossover Study
Sign Up to like & getrecommendations! Published in 2019 at "Advances in Therapy"
DOI: 10.1007/s12325-019-00956-z
Abstract: IntroductionTo investigate the absolute bioavailability of esaxerenone and the effects of food on its pharmacokinetics (PK) after a single oral dose in healthy Japanese subjects.MethodsTwenty-four Japanese males aged 20–45 years were randomised to six groups (each… read more here.
Keywords: esaxerenone; oral dose; absolute bioavailability; single oral ... See more keywords
Pharmacokinetics and pharmacokinetic/pharmacodynamic relationship of vicagrel, a novel thienopyridine P2Y12 inhibitor, compared with clopidogrel in healthy Chinese subjects following single oral dosing
Sign Up to like & getrecommendations! Published in 2019 at "European Journal of Pharmaceutical Sciences"
DOI: 10.1016/j.ejps.2018.10.011
Abstract: Background and objectives Vicagrel, a novel thienopyridine antiplatelet agent, is an analogue of clopidogrel in development for the treatment of acute coronary syndromes. This study investigated the pharmacokinetic properties of vicagrel after single oral dosing… read more here.
Keywords: healthy chinese; clopidogrel; vicagrel; compared clopidogrel ... See more keywords
0500 Evaluation of the Human Abuse Potential of Single Oral Doses of V117957, a Novel, Highly Potent and Selective Partial Agonist for Nociceptin/Orphanin-FQ Peptide (NOP) Receptors
Sign Up to like & getrecommendations! Published in 2020 at "Sleep"
DOI: 10.1093/sleep/zsaa056.497
Abstract: The satisfactory safety/tolerability profile of V117957, an investigational NOP receptor partial agonist, has been previously established in ~200 healthy subjects with maximum doses at 30mg following a single oral administration and 10mg once daily for… read more here.
Keywords: abuse potential; v117957 1mg; placebo; partial agonist ... See more keywords
Comparative pharmacokinetics of a single oral dose of meloxicam in the California sea lion (Zalophus californianus) and Pacific harbor seal (Phoca vitulina richardii).
Sign Up to like & getrecommendations! Published in 2024 at "Journal of veterinary pharmacology and therapeutics"
DOI: 10.1111/jvp.13469
Abstract: Pharmacokinetics studies have investigated meloxicam, a non-steroidal anti-inflammatory drug, dosing strategies in a wide variety of non-domestic animals; however, there is no prior study examining well-founded dosing for pinnipeds. To develop dosing protocols, pharmacokinetic information… read more here.
Keywords: phoca vitulina; california sea; zalophus californianus; single oral ... See more keywords
Pharmacokinetics and Physiological Effects of a Single Oral Dose of Oxycodone in Healthy Dogs: A Pilot Study.
Sign Up to like & getrecommendations! Published in 2025 at "Journal of veterinary pharmacology and therapeutics"
DOI: 10.1111/jvp.13499
Abstract: Oxycodone, a full mu opioid receptor agonist prescribed for moderate-to-severe pain in people, could provide outpatient analgesia for dogs with post-operative or cancer pain. To determine the pharmacokinetic profile and physiological side effects of a… read more here.
Keywords: oral dose; oxycodone; plasma concentration; single oral ... See more keywords
Population Pharmacokinetics of Sarafloxacin in Yellow River Carp (Cyprinus carpio Haematopterus) After One Single Oral Dose
Sign Up to like & getrecommendations! Published in 2025 at "Journal of Veterinary Pharmacology and Therapeutics"
DOI: 10.1111/jvp.70021
Abstract: The objective of this study was to investigate the population pharmacokinetics of sarafloxacin following a single oral administration at a dose of 20 mg/kg body weight (BW) in Yellow River carp (Cyprinus carpio haematopterus) reared at… read more here.
Keywords: yellow river; population; single oral; river carp ... See more keywords
Thorough QT Study To Evaluate the Effect of Zoliflodacin, a Novel Therapeutic for Gonorrhea, on Cardiac Repolarization in Healthy Adults
Sign Up to like & getrecommendations! Published in 2021 at "Antimicrobial Agents and Chemotherapy"
DOI: 10.1128/aac.01292-21
Abstract: Zoliflodacin is a novel spiropyrimidinetrione antibiotic being developed as single oral dose treatment to address the growing global threat of Neisseria gonorrhoeae. To evaluate the cardiac safety of zoliflodacin, a thorough QT/QTc (TQT) study was… read more here.
Keywords: oral dose; study; zoliflodacin; zoliflodacin novel ... See more keywords
High Resolution Free Triiodothyronine-Thyrotropin (FT3-TSH) Responses to a Single Oral Dose of Liothyronine in Humans: Evidence of Distinct Inter-Individual Differences Unraveled Using an Electrical Network Model.
Sign Up to like & getrecommendations! Published in 2017 at "Journal of biological systems"
DOI: 10.1142/s0218339017500073
Abstract: The effects of a single oral dose of liothyronine (L-T3) on thyroid stimulating hormone (TSH) and other related thyroid system parameters are partly understood despite therapeutic use of this hormone over many decades. We characterize… read more here.
Keywords: using electrical; oral dose; model; dose liothyronine ... See more keywords