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   Articles with "single prolonged" as a keyword



Dysregulation of miR-142 results in anxiety-like behaviors following single prolonged stress

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recommendations! Published in 2019 at "Behavioural Brain Research"

DOI: 10.1016/j.bbr.2019.03.018

Abstract: &NA; Posttraumatic stress disorder (PTSD) is a prevalent mental disorder that is classified as a trauma‐ and stressor‐related disorder. While numerous epigenetic factors are related to the risk for PTSD, the precise mechanisms underlying this… read more here.

Keywords: single prolonged; anxiety like; mir 142; stress ... See more keywords

Neonatal isolation modulates glucocorticoid-receptor function and synaptic plasticity of hippocampal and amygdala neurons in a rat model of single prolonged stress.

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recommendations! Published in 2019 at "Journal of affective disorders"

DOI: 10.1016/j.jad.2018.12.084

Abstract: BACKGROUND Early life and stressful experiences affect hippocampal and amygdala structure and function. They also increase the incidence of mental and nervous system disorders in adults. However, prospective studies have yet to show if early-life… read more here.

Keywords: neonatal isolation; single prolonged; sps alone; stress ... See more keywords

Use of Single Prolonged Stress to Model Post-traumatic Stress Disorder in Rodents: What we Found and Where to Next?

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recommendations! Published in 2025 at "Current Neuropharmacology"

DOI: 10.2174/011570159x377560250629183749

Abstract: Post-traumatic stress disorder (PTSD) represents a grave and expansive mental illness, caused by experiencing or witnessing traumatic events that invoke profound feelings of helplessness, fear and anxiety. Reflecting the clinical features of PTSD, the single… read more here.

Keywords: stress disorder; single prolonged; stress; model ... See more keywords

An Advanced Transcriptional Response to Corticosterone After Single Prolonged Stress in Male Rats

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recommendations! Published in 2021 at "Frontiers in Behavioral Neuroscience"

DOI: 10.3389/fnbeh.2021.756903

Abstract: Stress-related neuropsychiatric disorders are often accompanied by dysfunction of the hypothalamic-pituitary-adrenal (HPA) axis. In patients suffering from post-traumatic stress disorder (PTSD), increased sensitivity of glucocorticoid negative feedback has regularly been observed. The single prolonged stress… read more here.

Keywords: single prolonged; prolonged stress; negative feedback; corticosterone ... See more keywords

Sex-dependent effects of microglial reduction on impaired fear extinction induced by single prolonged stress

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recommendations! Published in 2023 at "Frontiers in Behavioral Neuroscience"

DOI: 10.3389/fnbeh.2022.1014767

Abstract: Single prolonged stress (SPS) is a preclinical rodent model for studying post-traumatic stress disorder (PTSD)-like behaviors. Previously we found that increased expression of the microglial marker Iba-1 in the ventral hippocampus after SPS exposure was… read more here.

Keywords: stress; fear extinction; extinction; single prolonged ... See more keywords

Single Prolonged Stress Decreases the Level of Adult Hippocampal Neurogenesis in C57BL/6, but Not in House Mice

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recommendations! Published in 2023 at "Current Issues in Molecular Biology"

DOI: 10.3390/cimb45010035

Abstract: Many people experience traumatic events during their lives, but not all of them develop severe mental pathologies, characterized by high levels of anxiety that persists for more than a month after psychological trauma, such as… read more here.

Keywords: house; stress; c57bl; single prolonged ... See more keywords

Sex differences in acetylcholinesterase modulation during spatial and fear memory extinction in the amygdala; an animal study in the single prolonged stress model of PTSD

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recommendations! Published in 2022 at "Research in Pharmaceutical Sciences"

DOI: 10.4103/1735-5362.359435

Abstract: Background and purpose: Men and women show different reactions to trauma and that is believed to be the reason behind the higher prevalence of post-traumatic stress disorder (PTSD) in women. Cholinergic signaling has long been… read more here.

Keywords: memory extinction; extinction; single prolonged; ptsd ... See more keywords