Effects of histatin 5 modifications on antifungal activity and kinetics of proteolysis
Sign Up to like & getrecommendations! Published in 2019 at "Protein Science"
DOI: 10.1002/pro.3767
Abstract: Histatin 5 (Hst‐5) is an antimicrobial peptide with strong antifungal activity against Candida albicans, an opportunistic pathogen that is a common cause of oral thrush. The peptide is natively secreted by human salivary glands and… read more here.
Keywords: single residue; proteolysis; effects histatin; histatin modifications ... See more keywords
Effect of single-residue bulges on RNA double-helical structures: crystallographic database analysis and molecular dynamics simulation studies
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Molecular Modeling"
DOI: 10.1007/s00894-017-3480-z
Abstract: Asymmetric bulge loop motifs are widely dispersed in all types of functional RNAs. They are frequently occurring structural motifs in folded RNA structures and appear commonly in pre-microRNA and ribosomes, where they are involved in… read more here.
Keywords: single residue; residue; molecular dynamics; rna ... See more keywords
Quantitative Single-Residue Bioorthogonal Labeling of G Protein-Coupled Receptors in Live Cells.
Sign Up to like & getrecommendations! Published in 2019 at "ACS chemical biology"
DOI: 10.1021/acschembio.8b01115
Abstract: High-end microscopy studies of G protein-coupled receptors (GPCRs) require installing onto the receptors bright and photostable dyes. Labeling must occur in quantitative yields, to allow stoichiometric data analysis, and in a minimally invasive fashion, to… read more here.
Keywords: single residue; microscopy; labeling; protein coupled ... See more keywords
Proteasomal degradation of the intrinsically disordered protein tau at single-residue resolution
Sign Up to like & getrecommendations! Published in 2020 at "Science Advances"
DOI: 10.1126/sciadv.aba3916
Abstract: Dissecting the degradation of the Alzheimer’s disease–related protein Tau by the 20S proteasome at single-residue resolution. Intrinsically disordered proteins (IDPs) can be degraded in a ubiquitin-independent process by the 20S proteasome. Decline in 20S activity… read more here.
Keywords: single residue; degradation; residue resolution; protein tau ... See more keywords
Effect of Single-Residue Mutations on CTCF Binding to DNA: Insights from Molecular Dynamics Simulations
Sign Up to like & getrecommendations! Published in 2023 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms24076395
Abstract: In humans and other eukaryotes, DNA is condensed into chromatin fibers that are further wound into chromosomes. This organization allows regulatory elements in the genome, often distant from each other in the linear DNA, to… read more here.
Keywords: dynamics simulations; single residue; dna; effect single ... See more keywords