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   Articles with "single strand" as a keyword



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Resolving human DNA mixtures with F-108 polymer and capillary electrophoresis single-strand conformational polymorphism analysis.

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recommendations! Published in 2020 at "Journal of separation science"

DOI: 10.1002/jssc.202000194

Abstract: Current technologies have increased the sensitivity for analyzing forensic DNA samples, especially those considered "touch samples." Because of this, there has been an increase in the number of forensic mixtures-two or more contributors within a… read more here.

Keywords: polymorphism; 108 polymer; single strand; strand conformational ... See more keywords

Single-strand specific nuclease enhances accuracy of error-corrected sequencing and improves rare mutation-detection sensitivity.

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recommendations! Published in 2021 at "Archives of toxicology"

DOI: 10.1007/s00204-021-03185-y

Abstract: Error-corrected sequences (ECSs) that utilize double-stranded DNA sequences are useful in detecting mutagen-induced mutations. However, relatively higher frequencies of G:C > T:A (1 × 10-7 bp) and G:C > C:G (2 × 10-7 bp) errors decrease the accuracy of detection of rare G:C mutations (approximately… read more here.

Keywords: detection; error corrected; nuclease; mutation detection ... See more keywords
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Imaging DNA single-strand breaks generated by reactive oxygen species using a liquid crystal-based sensor.

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recommendations! Published in 2018 at "Analytical biochemistry"

DOI: 10.1016/j.ab.2018.06.009

Abstract: DNA single-strand breaks (SSBs) have attracted much interest since they are highly related to carcinogenesis and ageing. Herein, we report a new liquid crystal (LC)-based sensor for the detection of DNA SSBs generated by reactive… read more here.

Keywords: dna; dna single; liquid crystal; strand breaks ... See more keywords

Characterization of TK1646, a highly thermostable 3'-5' single strand specific exonuclease from Thermococcus kodakarensis.

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recommendations! Published in 2019 at "International journal of biological macromolecules"

DOI: 10.1016/j.ijbiomac.2019.08.150

Abstract: Exonucleases catalyze the hydrolysis of terminal phosphodiester bond in nucleic acid. They play important role in maintaining the integrity of DNA in eukaryotes, prokaryotes and archaea. Limited studies have been done on archaeal exonucleases. Here… read more here.

Keywords: strand specific; single strand; exonuclease; specific exonuclease ... See more keywords

FANCA Promotes DNA Double-Strand Break Repair by Catalyzing Single-Strand Annealing and Strand Exchange.

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recommendations! Published in 2018 at "Molecular cell"

DOI: 10.1016/j.molcel.2018.06.030

Abstract: FANCA is a component of the Fanconi anemia (FA) core complex that activates DNA interstrand crosslink repair by monoubiquitination of FANCD2. Here, we report that purified FANCA protein catalyzes bidirectional single-strand annealing (SA) and strand… read more here.

Keywords: annealing strand; strand; single strand; strand annealing ... See more keywords
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Single-strand and ladder-type polymeric acceptors based on regioisomerically-pure perylene diimides towards all-polymer solar cells

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recommendations! Published in 2019 at "Polymer"

DOI: 10.1016/j.polymer.2018.12.041

Abstract: Abstract Since dibromo perylene diimides (DBPDIs) contain two isomers that are difficult to separate, isomeric effect on properties and applications of PDI polymers has been rarely studied. Few ladder-type polymers have been used in organic… read more here.

Keywords: solar cells; regioisomerically pure; polymer solar; ladder type ... See more keywords

Organic electrochemical transistor-based channel dimension-independent single-strand wearable sweat sensors

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recommendations! Published in 2018 at "NPG Asia Materials"

DOI: 10.1038/s41427-018-0097-3

Abstract: Despite the great potential of polymer microfibers in human-friendly wearable electronics, most previous polymeric electronics have been limited to thin-film-based devices due to practical difficulties in fabricating microfibrillar devices, as well as defining the active… read more here.

Keywords: sweat; organic electrochemical; strand; ion ... See more keywords

Mechanistic and genetic basis of single-strand templated repair at Cas12a-induced DNA breaks in Chlamydomonas reinhardtii.

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recommendations! Published in 2021 at "Nature communications"

DOI: 10.1038/s41467-021-27004-1

Abstract: Single-stranded oligodeoxynucleotides (ssODNs) are widely used as DNA repair templates in CRISPR/Cas precision genome editing. However, the underlying mechanisms of single-strand templated DNA repair (SSTR) are inadequately understood, constraining rational improvements to precision editing. Here… read more here.

Keywords: strand templated; cas12a induced; single strand; repair ... See more keywords

LNA effects on DNA binding and conformation: from single strand to duplex and triplex structures

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recommendations! Published in 2017 at "Scientific Reports"

DOI: 10.1038/s41598-017-09147-8

Abstract: The anti-gene strategy is based on sequence-specific recognition of double-strand DNA by triplex forming (TFOs) or DNA strand invading oligonucleotides to modulate gene expression. To be efficient, the oligonucleotides (ONs) should target DNA selectively, with… read more here.

Keywords: lna effects; duplex triplex; effects dna; strand ... See more keywords

The role of DNA polymerase I in tolerating single-strand breaks generated at clustered DNA damage in Escherichia coli

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recommendations! Published in 2024 at "Scientific Reports"

DOI: 10.1038/s41598-024-69823-4

Abstract: Clustered DNA damage, when multiple lesions are generated in close proximity, has various biological consequences, including cell death, chromosome aberrations, and mutations. It is generally perceived as a hallmark of ionizing radiation. The enhanced mutagenic… read more here.

Keywords: dna polymerase; strand; damage; single strand ... See more keywords

Parp1 deletion rescues cerebellar hypotrophy in xrcc1 mutant zebrafish

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recommendations! Published in 2025 at "Scientific Reports"

DOI: 10.1038/s41598-025-01870-x

Abstract: Defects in DNA single-strand break repair are associated with neurodevelopmental and neurodegenerative disorders. One such disorder is that resulting from mutations in XRCC1, a scaffold protein that plays a central role in DNA single-strand base… read more here.

Keywords: rescues cerebellar; xrcc1; zebrafish; xrcc1 mutant ... See more keywords