The flashfm approach for fine-mapping multiple quantitative traits.
Sign Up to like & getrecommendations! Published in 2021 at "Nature communications"
DOI: 10.1038/s41467-021-26364-y
Abstract: Joint fine-mapping that leverages information between quantitative traits could improve accuracy and resolution over single-trait fine-mapping. Using summary statistics, flashfm (flexible and shared information fine-mapping) fine-maps signals for multiple traits, allowing for missing trait measurements… read more here.
Keywords: causal variants; mapping; single trait; fine mapping ... See more keywords
Multitrait genome association analysis identifies new susceptibility genes for human anthropometric variation in the GCAT cohort
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Medical Genetics"
DOI: 10.1136/jmedgenet-2018-105437
Abstract: Background Heritability estimates have revealed an important contribution of SNP variants for most common traits; however, SNP analysis by single-trait genome-wide association studies (GWAS) has failed to uncover their impact. In this study, we applied… read more here.
Keywords: analysis; single trait; association; cohort ... See more keywords
Prediction Strategies for Leveraging Information of Associated Traits under Single- and Multi-Trait Approaches in Soybeans
Sign Up to like & getrecommendations! Published in 2020 at "Agriculture"
DOI: 10.3390/agriculture10080308
Abstract: The availability of molecular markers has revolutionized conventional ways to improve genotypes in plant and animal breeding through genome-based predictions. Several models and methods have been developed to leverage the genomic information in the prediction… read more here.
Keywords: trait; information; trait model; single trait ... See more keywords
A genome-wide association study of reproduction traits in four pig populations with different genetic backgrounds
Sign Up to like & getrecommendations! Published in 2019 at "Asian-Australasian Journal of Animal Sciences"
DOI: 10.5713/ajas.19.0411
Abstract: Objective Genome-wide association study and two meta-analysis based on GWAS performed to explore the genetic mechanism underlying variation in pig number born alive (NBA) and total number born (TNB). Methods Single trait GWAS and two… read more here.
Keywords: trait; analysis; single trait; trait meta ... See more keywords