Thylakoid Membranes with Unique Photosystems Used to Simultaneously Produce Self-Supplying Oxygen and Singlet Oxygen for Hypoxic Tumor Therapy.
Sign Up to like & getrecommendations! Published in 2021 at "Advanced healthcare materials"
DOI: 10.1002/adhm.202001666
Abstract: Photodynamic therapy (PDT) efficacy has been dramatically limited by the insufficient oxygen (O2 ) level in hypoxic tumors. Although various PDT nanosystems have been designed to deliver or produce O2 in support of reactive oxygen… read more here.
Keywords: oxygen; thylakoid membranes; singlet oxygen; therapy ... See more keywords
Anthracene‐Based Endoperoxides as Self‐Sensitized Singlet Oxygen Carriers for Hypoxic‐Tumor Photodynamic Therapy
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DOI: 10.1002/adhm.202403009
Abstract: Singlet oxygen is a crucial reactive oxygen species (ROS) in photodynamic therapy (PDT). However, the hypoxic tumor microenvironment limits the production of cytotoxic singlet oxygen through the light irradiation of PDT photosensitizers (PSs). This restriction… read more here.
Keywords: hypoxic tumor; singlet oxygen; self sensitized; singlet ... See more keywords
A Singlet Oxygen Generating Agent by Chirality-dependent Plasmonic Shell-Satellite Nanoassembly.
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DOI: 10.1002/adma.201606864
Abstract: Photodynamic therapy (PDT) agent, which generates singlet oxygen (1 O2 ) under light, has attracted significant attention for its broad biological and medical applications. Here, DNA-driven shell-satellite (SS) gold assemblies as chiral photosensitizers are first… read more here.
Keywords: singlet oxygen; oxygen; dependent; shell satellite ... See more keywords
Singlet Oxygen "Afterglow" Therapy with NIR-II Fluorescent Molecules.
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DOI: 10.1002/adma.202103627
Abstract: Improving singlet oxygen (1 O2 ) lifespan by fractionated delivery in dark and hypoxic conditions is a better way to achieve enhanced phototherapeutic efficacy. Herein, three boron dipyrromethene (BODIPY) dyes are synthesized to demonstrate that… read more here.
Keywords: oxygen; nir fluorescent; singlet oxygen; therapy nir ... See more keywords
Spatial Band Separation in a Surface Doped Heterolayered Structure for Realizing Efficient Singlet Oxygen Generation
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DOI: 10.1002/adma.202206516
Abstract: Singlet oxygen (1O2) with electrical neutrality and long lifetime holds great promise in producing high‐added‐value chemicals via a selective oxidation reaction. However, photocatalytic 1O2 generation via the charge‐transfer mechanism still suffers from low efficiency due… read more here.
Keywords: generation; 1o2 generation; structure; singlet oxygen ... See more keywords
Constructing Singlet Oxygen “Slow Release” Platform to Optimize the Performance of Commercial Photosensitizers
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DOI: 10.1002/adom.202302834
Abstract: Commercial photosensitizers (PSs) present great potential in the field of clinical photodynamic therapy (PDT) yet face a formidable challenge owing to the extremely short lifespan of singlet oxygen (1O2). Herein, the 1O2 slow‐release “platform” is… read more here.
Keywords: commercial photosensitizers; release platform; slow release; singlet oxygen ... See more keywords
Enhanced Efficacy of Gefitinib in Drug‐Sensitive and Drug‐Resistant Cancer Cell Lines after Arming with a Singlet Oxygen Releasing Moiety
Sign Up to like & getrecommendations! Published in 2020 at "ChemMedChem"
DOI: 10.1002/cmdc.202000036
Abstract: Attractive results have been achieved with small‐molecule target‐based drugs in the anticancer field; however, enhancing their treatment effect and solving the problem of drug resistance remain key concerns worldwide. Inspired by the specific affinity of… read more here.
Keywords: drug; singlet oxygen; releasing moiety;
Fine-Tuning Plasmon-Molecule Interactions in Gold-BODIPY Nanocomposites: The Role of Chemical Structure and Noncovalent Interactions.
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DOI: 10.1002/cplu.202000545
Abstract: Strong coupling between localized surface plasmons and molecular absorptions leads to remarkable changes in the photophysical properties of dye-loaded metal nanoparticles. Here, we report supramolecular nanocomposites consisting of BODIPY, tryptophan, and gold nanoparticles, and investigate… read more here.
Keywords: fine tuning; plasmon molecule; singlet oxygen; interactions gold ... See more keywords
Controlled, Sunlight-Driven Reversible Cycloaddition of Multiple Singlet Oxygen Molecules to Anthracene-Containing Trianglimine Macrocycles.
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DOI: 10.1002/cplu.202100510
Abstract: Controlled release of singlet oxygen is of interest not only to chemists, but also to biologists and medics involved in cancer therapy. Two chiral polyaza macrocyclic compounds and their corresponding endoperoxides have been synthesized. These… read more here.
Keywords: controlled sunlight; sunlight driven; driven reversible; singlet oxygen ... See more keywords
Singlet Oxygen Generation in Peripherally Modified Platinum and Palladium Porphyrins: Effect of Triplet Excited State Lifetimes and meso-Substituents on 1 O2 Quantum Yields.
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DOI: 10.1002/cplu.202200010
Abstract: A series of meso-substituted with aromatic (=tolyl, pyrenyl, fluorenyl, naphthyl, and triphenylamine) substituents, platinum (Pt), and palladium (Pd) porphyrins have been synthesized and characterized by spectroscopic and single-crystal X-ray diffraction studies to probe structure-reactivity aspects… read more here.
Keywords: platinum palladium; quantum yields; singlet oxygen; meso substituents ... See more keywords
Luminescent Lanthanide Complexes for Effective Oxygen-Sensing and Singlet Oxygen Generation.
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DOI: 10.1002/cplu.202200445
Abstract: Oxygen quantification using luminescence has attracted considerable attention in various fields, including environmental monitoring and clinical analysis. Among the reported luminophores, trivalent lanthanide complexes have displayed characteristic narrow emission bands with high brightness. This bright… read more here.
Keywords: oxygen generation; oxygen sensing; singlet oxygen; oxygen ... See more keywords