Effects of fibroblast-myocyte coupling on the sinoatrial node activity: A computational study.
Sign Up to like & getrecommendations! Published in 2018 at "International journal for numerical methods in biomedical engineering"
DOI: 10.1002/cnm.2966
Abstract: While the sinoatrial node (SAN) is structurally heterogeneous, most computer simulations of electrical activity take into account SAN pacemaker cells only. Our aim was to investigate how fibroblasts affect the SAN activity. We simulated the… read more here.
Keywords: sinoatrial node; fibroblast myocyte; leading centers; myocyte coupling ... See more keywords
TRPM7 regulates angiotensin II-induced sinoatrial node fibrosis in sick sinus syndrome rats by mediating Smad signaling
Sign Up to like & getrecommendations! Published in 2018 at "Heart and Vessels"
DOI: 10.1007/s00380-018-1146-0
Abstract: Sinoatrial node fibrosis is involved in the pathogenesis of sinus sick syndrome (SSS). Transient receptor potential (TRP) subfamily M member 7 (TRPM7) is implicated in cardiac fibrosis. However, the mechanisms underlying the regulation of sinoatrial… read more here.
Keywords: sinoatrial node; trpm7; fibrosis; sss ... See more keywords
Transcriptome Profile of Sinoatrial Node in AC8 Transgenic Mice
Sign Up to like & getrecommendations! Published in 2017 at "Biophysical Journal"
DOI: 10.1016/j.bpj.2016.11.1168
Abstract: Transgenic (TG) mice overexpressing the human adenylate cyclase 8 (AC8) gene have markedly higher intrinsic (in the presence of dual autonomic blockade) heart rates than their wild type (WT) littermates. To understand the mechanisms underlying… read more here.
Keywords: sinoatrial node; transgenic mice; expression; ac8 mice ... See more keywords
Ionic mechanisms of the action of anaesthetics on sinoatrial node automaticity
Sign Up to like & getrecommendations! Published in 2017 at "European Journal of Pharmacology"
DOI: 10.1016/j.ejphar.2017.08.006
Abstract: ABSTRACT Although various general anaesthetics affect the heart rate in clinical settings, their precise mechanisms remain to be fully elucidated. Because the heart rate is determined by automaticity of the cardiac pacemaker sinoatrial node and… read more here.
Keywords: sinoatrial node; anaesthetics sinoatrial; node automaticity; ionic mechanisms ... See more keywords
Impaired neuronal sodium channels cause intranodal conduction failure and reentrant arrhythmias in human sinoatrial node
Sign Up to like & getrecommendations! Published in 2020 at "Nature Communications"
DOI: 10.1038/s41467-019-14039-8
Abstract: Mechanisms for human sinoatrial node (SAN) dysfunction are poorly understood and whether human SAN excitability requires voltage-gated sodium channels (Nav) remains controversial. Here, we report that neuronal (n)Nav blockade and selective nNav1.6 blockade during high-resolution… read more here.
Keywords: sinoatrial node; sodium channels; intranodal conduction; human sinoatrial ... See more keywords
What makes the sinoatrial node tick? A question not for the faint of heart
Sign Up to like & getrecommendations! Published in 2023 at "Philosophical Transactions of the Royal Society B: Biological Sciences"
DOI: 10.1098/rstb.2022.0180
Abstract: Even before the sinoatrial node (SAN) was discovered, cardiovascular science was engaged in an active investigation of when and why the heart would beat. After the electrochemical theory of bioelectric membrane potentials was formulated and… read more here.
Keywords: makes sinoatrial; sinoatrial node; tick question; heart ... See more keywords
Telocytes in the human sinoatrial node
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Cellular and Molecular Medicine"
DOI: 10.1111/jcmm.13340
Abstract: The sinoatrial node (SAN) is composed mostly of pacemaker, transitional and Purkinje‐like cells. Pacemaker cells, especially in the centre of the SAN, are surrounded by dense fibrous tissue and do not have any contact with… read more here.
Keywords: sinoatrial node; pacemaker cells; microscopy; telocytes human ... See more keywords
The Pattern of mRNA Expression Is Changed in Sinoatrial Node from Goto-Kakizaki Type 2 Diabetic Rat Heart
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Diabetes Research"
DOI: 10.1155/2018/8454078
Abstract: Background In vivo experiments in Goto-Kakizaki (GK) type 2 diabetic rats have demonstrated reductions in heart rate from a young age. The expression of genes encoding more than 70 proteins that are associated with the… read more here.
Keywords: sinoatrial node; goto kakizaki; heart; type diabetic ... See more keywords
ATAC-Seq Reveals an Isl1 Enhancer That Regulates Sinoatrial Node Development and Function
Sign Up to like & getrecommendations! Published in 2020 at "Circulation Research"
DOI: 10.1161/circresaha.120.317145
Abstract: Supplemental Digital Content is available in the text. Rationale: Cardiac pacemaker cells (PCs) in the sinoatrial node (SAN) have a distinct gene expression program that allows them to fire automatically and initiate the heartbeat. Although… read more here.
Keywords: sinoatrial node; atac seq; development; gene ... See more keywords
Fibroblast-Specific Proteotranscriptomes Reveal Distinct Fibrotic Signatures of Human Sinoatrial Node in Nonfailing and Failing Hearts
Sign Up to like & getrecommendations! Published in 2021 at "Circulation"
DOI: 10.1161/circulationaha.120.051583
Abstract: Supplemental Digital Content is available in the text. Background: Up to 50% of the adult human sinoatrial node (SAN) is composed of dense connective tissue. Cardiac diseases including heart failure (HF) may increase fibrosis within… read more here.
Keywords: sinoatrial node; human sinoatrial; fibroblast specific; failing hearts ... See more keywords
Hippo-Yap Signaling Maintains Sinoatrial Node Homeostasis
Sign Up to like & getrecommendations! Published in 2022 at "Circulation"
DOI: 10.1161/circulationaha.121.058777
Abstract: Background: The sinoatrial node (SAN) functions as the pacemaker of the heart, initiating rhythmic heartbeats. Despite its importance, the SAN is one of the most poorly understood cardiac entities because of its small size and… read more here.
Keywords: sinoatrial node; yap; hippo; hippo signaling ... See more keywords