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   Articles with "sinoatrial node" as a keyword



Effects of fibroblast-myocyte coupling on the sinoatrial node activity: A computational study.

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recommendations! Published in 2018 at "International journal for numerical methods in biomedical engineering"

DOI: 10.1002/cnm.2966

Abstract: While the sinoatrial node (SAN) is structurally heterogeneous, most computer simulations of electrical activity take into account SAN pacemaker cells only. Our aim was to investigate how fibroblasts affect the SAN activity. We simulated the… read more here.

Keywords: sinoatrial node; fibroblast myocyte; leading centers; myocyte coupling ... See more keywords

Analysis of changes in the action potential morphology of the mouse sinoatrial node true pacemaker cells during ontogenetic development in vitro and in silico

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recommendations! Published in 2024 at "Developmental Dynamics"

DOI: 10.1002/dvdy.701

Abstract: Maturation of the mouse is accompanied by the increase in heart rate. However, the mechanisms underlying this process remain unclear. We performed an action potentials (APs) recordings in mouse sinoatrial node (SAN) true pacemaker cells… read more here.

Keywords: true pacemaker; mouse sinoatrial; pacemaker cells; action ... See more keywords

TRPM7 regulates angiotensin II-induced sinoatrial node fibrosis in sick sinus syndrome rats by mediating Smad signaling

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recommendations! Published in 2018 at "Heart and Vessels"

DOI: 10.1007/s00380-018-1146-0

Abstract: Sinoatrial node fibrosis is involved in the pathogenesis of sinus sick syndrome (SSS). Transient receptor potential (TRP) subfamily M member 7 (TRPM7) is implicated in cardiac fibrosis. However, the mechanisms underlying the regulation of sinoatrial… read more here.

Keywords: sinoatrial node; trpm7; fibrosis; sss ... See more keywords

Rare origin of the sinoatrial node artery: an anatomic report and a brief review of the literature

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recommendations! Published in 2024 at "Anatomical Science International"

DOI: 10.1007/s12565-024-00779-1

Abstract: Several studies reported anatomical variations in the sinoatrial node artery (SANa). Here, we report a rare variation in the origin of the SANa on a human adult male cadaver. During dissection, we identified the SANa… read more here.

Keywords: report; sinoatrial node; artery; right atrium ... See more keywords

Transcriptome Profile of Sinoatrial Node in AC8 Transgenic Mice

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recommendations! Published in 2017 at "Biophysical Journal"

DOI: 10.1016/j.bpj.2016.11.1168

Abstract: Transgenic (TG) mice overexpressing the human adenylate cyclase 8 (AC8) gene have markedly higher intrinsic (in the presence of dual autonomic blockade) heart rates than their wild type (WT) littermates. To understand the mechanisms underlying… read more here.

Keywords: sinoatrial node; transgenic mice; expression; ac8 mice ... See more keywords

Ionic mechanisms of the action of anaesthetics on sinoatrial node automaticity

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recommendations! Published in 2017 at "European Journal of Pharmacology"

DOI: 10.1016/j.ejphar.2017.08.006

Abstract: ABSTRACT Although various general anaesthetics affect the heart rate in clinical settings, their precise mechanisms remain to be fully elucidated. Because the heart rate is determined by automaticity of the cardiac pacemaker sinoatrial node and… read more here.

Keywords: sinoatrial node; anaesthetics sinoatrial; node automaticity; ionic mechanisms ... See more keywords

Impaired neuronal sodium channels cause intranodal conduction failure and reentrant arrhythmias in human sinoatrial node

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recommendations! Published in 2020 at "Nature Communications"

DOI: 10.1038/s41467-019-14039-8

Abstract: Mechanisms for human sinoatrial node (SAN) dysfunction are poorly understood and whether human SAN excitability requires voltage-gated sodium channels (Nav) remains controversial. Here, we report that neuronal (n)Nav blockade and selective nNav1.6 blockade during high-resolution… read more here.

Keywords: sinoatrial node; sodium channels; intranodal conduction; human sinoatrial ... See more keywords

Ectopic Pitx2 expression and sinoatrial node dysfunction in mice recapitulating a novel cardiac syndrome identified in unrelated families with deletions in a gene desert on chromosome 4q25

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recommendations! Published in 2024 at "Cardiovascular Research"

DOI: 10.1093/cvr/cvae088.107

Abstract: Type of funding sources: Public grant(s) – National budget only. Main funding source(s): Dutch Research Councin/NWO Several unrelated families presenting with a complex, heterogeneous cardiac syndrome including sinoatrial node dysfunction and atrial fibrillation were found… read more here.

Keywords: gene desert; node dysfunction; expression; sinoatrial node ... See more keywords

What makes the sinoatrial node tick? A question not for the faint of heart

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recommendations! Published in 2023 at "Philosophical Transactions of the Royal Society B: Biological Sciences"

DOI: 10.1098/rstb.2022.0180

Abstract: Even before the sinoatrial node (SAN) was discovered, cardiovascular science was engaged in an active investigation of when and why the heart would beat. After the electrochemical theory of bioelectric membrane potentials was formulated and… read more here.

Keywords: makes sinoatrial; sinoatrial node; tick question; heart ... See more keywords
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Telocytes in the human sinoatrial node

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recommendations! Published in 2018 at "Journal of Cellular and Molecular Medicine"

DOI: 10.1111/jcmm.13340

Abstract: The sinoatrial node (SAN) is composed mostly of pacemaker, transitional and Purkinje‐like cells. Pacemaker cells, especially in the centre of the SAN, are surrounded by dense fibrous tissue and do not have any contact with… read more here.

Keywords: sinoatrial node; pacemaker cells; microscopy; telocytes human ... See more keywords

The Pattern of mRNA Expression Is Changed in Sinoatrial Node from Goto-Kakizaki Type 2 Diabetic Rat Heart

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recommendations! Published in 2018 at "Journal of Diabetes Research"

DOI: 10.1155/2018/8454078

Abstract: Background In vivo experiments in Goto-Kakizaki (GK) type 2 diabetic rats have demonstrated reductions in heart rate from a young age. The expression of genes encoding more than 70 proteins that are associated with the… read more here.

Keywords: sinoatrial node; goto kakizaki; heart; type diabetic ... See more keywords