Metabolic profiling and transcriptome analysis of Sinomenium acutum provide insights into the biosynthesis of structurally diverse benzylisoquinoline alkaloids
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DOI: 10.1038/s41598-025-90334-3
Abstract: Sinomenium acutum, a traditional medicinal plant, has been utilized for millennia to alleviate various forms of rheumatic pain symptoms. The structurally diverse benzylisoquinoline alkaloids (BIAs) found in S. acutum are the primary contributors to its… read more here.
Keywords: sinomenium acutum; analysis; benzylisoquinoline alkaloids; biosynthesis ... See more keywords
Cloning, heterologous expression, and expression analysis of SinSyn7 gene from Sinomenium acutum
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DOI: 10.1371/journal.pone.0327959
Abstract: The main component of Sinomenium acutum, sinomenine, has anti-inflammatory, analgesic, and immunosuppressive effects. In order to achieve the biosynthesis of sinomenine, the synthase gene SinSyn7 was cloned from Sinomenium acutum and expressed heterologously in brewing… read more here.
Keywords: acutum; sinsyn7; sinomenium acutum; expression ... See more keywords
New N-oxide alkaloids from the stems of Sinomenium acutum.
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DOI: 10.2139/ssrn.4281979
Abstract: Six new alkaloids (1-6) and six known alkaloids (7-12) were obtained from the stems of Sinomenium acutum. Among them, compounds 1-3 and 6 were four N-oxide alkaloids. The structures and absolute configurations of these new… read more here.
Keywords: alkaloids stems; stems sinomenium; oxide alkaloids; new oxide ... See more keywords
Full-length transcriptome and metabolite analysis reveal reticuline epimerase-independent pathways for benzylisoquinoline alkaloids biosynthesis in Sinomenium acutum
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Plant Science"
DOI: 10.3389/fpls.2022.1086335
Abstract: Benzylisoquinoline alkaloids (BIAs) are a large family of plant natural products with important pharmaceutical applications. Sinomenium acutum is a medicinal plant from the Menispermaceae family and has been used to treat rheumatoid arthritis for hundreds… read more here.
Keywords: full length; biosynthesis; benzylisoquinoline alkaloids; sinomenium acutum ... See more keywords