Suppressing Subcapsular Sinus Macrophages Enhances Transport of Nanovaccines to Lymph Node Follicles for Robust Humoral Immunity.
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DOI: 10.1021/acsnano.0c02240
Abstract: Nanovaccines need to be transported to lymph node follicles to induce humoral immunity and generate neutralized antibody. Here we discovered that subcapsular sinus macrophages play a barrier role to prevent nanovaccines from accessing lymph node… read more here.
Keywords: antibody; subcapsular sinus; lymph node; node follicles ... See more keywords
Subcapsular Sinus Macrophages Promote Melanoma Metastasis to the Sentinel Lymph Nodes via an IL1α–STAT3 Axis
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DOI: 10.1158/2326-6066.cir-22-0225
Abstract: The authors show that subcapsular sinus macrophages promote aggressiveness of metastatic melanoma cells by releasing IL1α, which upregulates STAT3 signaling in the tumor. Blocking IL1α could synergize with STAT3 inhibitors in treating metastatic melanoma. read more here.
Keywords: promote melanoma; subcapsular sinus; il1; macrophages promote ... See more keywords