LAUSR: sip1 mutation

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Mutation in the Sip1 transcription factor leads to a disturbance of the preconditioning of AMPA receptors by episodes of hypoxia in neurons of the cerebral cortex due to changes in their activity and subunit composition. The protective effects of interleukin-10.

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0 Published in 2018 at "Archives of biochemistry and biophysics"

DOI: 10.1016/j.abb.2018.07.019

Abstract: The Sip1 mutation plays the main role in pathogenesis of the Mowat-Wilson syndrome, which is characterized by the pronounced epileptic symptoms. Cortical neurons of homozygous mice with Sip1 mutation are resistant to AMPA receptor activators.… read more here.

Keywords: sip1 mutation; episodes hypoxia; cortical neurons; ampa receptors ... See more keywords

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Mutation in the Sip1 transcription factor leads to a disturbance of the preconditioning of AMPA receptors by episodes of hypoxia in neurons of the cerebral cortex due to changes in their activity and subunit composition. The protective effects of interleukin-10.