New Sipanmycin Analogues Generated by Combinatorial Biosynthesis and Mutasynthesis Approaches Relying on the Substrate Flexibility of Key Enzymes in the Biosynthetic Pathway
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DOI: 10.1128/aem.02453-19
Abstract: Combinatorial biosynthesis has proved its usefulness in generating derivatives of already known compounds with novel or improved pharmacological properties. Sipanmycins are a family of glycosylated macrolactams produced by Streptomyces sp. strain CS149, whose antiproliferative activity… read more here.
Keywords: mutasynthesis approaches; flexibility; sipanmycin analogues; combinatorial biosynthesis ... See more keywords