The long and short of rDNA and yeast replicative aging
Sign Up to like & getrecommendations! Published in 2022 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.2205124119
Abstract: The budding yeast, Saccharomyces cerevisiae , is a popular single-cell eukaryotic model for studying mechanisms of aging, having played key roles in the identi fi cation and characterization of several conserved longevity factors, including the… read more here.
Keywords: rdna tandem; sir2; replicative aging; rdna ... See more keywords
A novel allele of SIR2 reveals a heritable intermediate state of gene silencing.
Sign Up to like & getrecommendations! Published in 2021 at "Genetics"
DOI: 10.1093/genetics/iyab041
Abstract: Genetic information acquires additional meaning through epigenetic regulation, the process by which genetically identical cells can exhibit heritable differences in gene expression and phenotype. Inheritance of epigenetic information is a critical step in maintaining cellular… read more here.
Keywords: state; sir2 reveals; allele sir2; novel allele ... See more keywords
Differences in Sirtuin Regulation in Response to Calorie Restriction in Cryptococcus neoformans
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Fungi"
DOI: 10.3390/jof4010026
Abstract: Cryptococcus neoformans successfully replicates in low glucose in infected patients. In the serotype A strain, H99, growth in this condition prolongs lifespan regulated by SIR2, and can be modulated with SIR2-specific drugs. Previous studies show… read more here.
Keywords: response calorie; calorie restriction; sir2; calorie ... See more keywords