Environment-Responsive Lipid/siRNA Nanoparticles for Cancer Therapy.
Sign Up to like & getrecommendations! Published in 2020 at "Advanced healthcare materials"
DOI: 10.1002/adhm.202001294
Abstract: RNA interference (RNAi) is a promising technology to regulate oncogenes for treating cancer. The primary limitation of siRNA for clinical application is the safe and efficacious delivery of therapeutic siRNA into target cells. Lipid-based delivery… read more here.
Keywords: sirna delivery; environment responsive; delivery; cancer ... See more keywords
Induced Self‐Assembly of Vitamin E‐Spermine/siRNA Nanocomplexes via Spermine/Helix Groove‐Specific Interaction for Efficient siRNA Delivery and Antitumor Therapy
Sign Up to like & getrecommendations! Published in 2024 at "Advanced Healthcare Materials"
DOI: 10.1002/adhm.202303186
Abstract: Gene therapy has been one of potential strategies for the treatment of different diseases, where efficient and safe gene delivery systems are also extremely in need. Current lipid nanoparticles (LNP) technology highly depends on the… read more here.
Keywords: sirna delivery; delivery; self assembled; spermine ... See more keywords
ROS-Responsive Polymeric siRNA Nanomedicine Stabilized by Triple Interactions for the Robust Glioblastoma Combinational RNAi Therapy.
Sign Up to like & getrecommendations! Published in 2019 at "Advanced materials"
DOI: 10.1002/adma.201903277
Abstract: Small interfering RNA (siRNA) holds inherent advantages and great potential for treating refractory diseases. However, lack of suitable siRNA delivery systems that demonstrate excellent circulation stability and effective at-site delivery ability is currently impeding siRNA… read more here.
Keywords: polymeric sirna; triple interactions; therapy; sirna ... See more keywords
Cation-Free siRNA Micelles as Effective Drug Delivery Platform and Potent RNAi Nanomedicines for Glioblastoma Therapy.
Sign Up to like & getrecommendations! Published in 2021 at "Advanced materials"
DOI: 10.1002/adma.202104779
Abstract: Nanoparticle-based small interfering RNA (siRNA) therapy shows great promise for glioblastoma (GBM). However, charge associated toxicity and limited blood-brain-barrier (BBB) penetration remain significant challenges for siRNA delivery for GBM therapy. Herein, novel cation-free siRNA micelles,… read more here.
Keywords: sirna micelles; rnai; drug; cation free ... See more keywords
Oral Delivery of siRNA Using Fluorinated, Small‐Sized Nanocapsules toward Anti‐Inflammation Treatment
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DOI: 10.1002/adma.202206821
Abstract: Oral delivery of small interfering RNA (siRNA) provides a promising paradigm for treating diseases that require regular injections. However, the multiple gastrointestinal (GI) and systemic barriers often lead to inefficient oral absorption and low bioavailability… read more here.
Keywords: anti inflammation; oral delivery; sirna; inflammation treatment ... See more keywords
Electrostatic Attractive Self-Delivery of siRNA and Light-Induced Self-Escape for Synergistic Gene Therapy.
Sign Up to like & getrecommendations! Published in 2023 at "Advanced materials"
DOI: 10.1002/adma.202301409
Abstract: Small interfering RNA (siRNA) holds immense promise for suppressing gene expression and treating various life-threatening diseases, including cancer. However, efficient delivery and lysosomal escape remain critical challenges that hinder the therapeutic effectiveness of siRNA. Herein,… read more here.
Keywords: tumor; sirna; siplk1 nps; escape ... See more keywords
High-Performance Multi-Dynamic Bond Cross-Linked Hydrogel with Spatiotemporal siRNA Delivery for Gene-Cell Combination Therapy of Intervertebral Disc Degeneration.
Sign Up to like & getrecommendations! Published in 2023 at "Advanced science"
DOI: 10.1002/advs.202206306
Abstract: Chronic inflammatory diseases, such as intervertebral disc degeneration (IVDD), which affect the lives of hundreds of millions of people, still lack effective and precise treatments. In this study, a novel hydrogel system with many extraordinary… read more here.
Keywords: cell; gene cell; cell combination; sirna ... See more keywords
Programmable Tetrahedral DNA‐RNA Nanocages Woven with Stimuli‐Responsive siRNA for Enhancing Therapeutic Efficacy of Multidrug‐Resistant Tumors
Sign Up to like & getrecommendations! Published in 2024 at "Advanced Science"
DOI: 10.1002/advs.202404112
Abstract: Multidrug resistance (MDR) is a major obstacle limiting the effectiveness of chemotherapy against cancer. The combination strategy of chemotherapeutic agents and siRNA targeting drug efflux has emerged as an effective cancer treatment to overcome MDR.… read more here.
Keywords: dna rna; programmable tetrahedral; tetrahedral dna; sirna ... See more keywords
Delivery of siRNA using hyaluronic acid‐guided nanoparticles for downregulation of CXCR4
Sign Up to like & getrecommendations! Published in 2023 at "Biopolymers"
DOI: 10.1002/bip.23535
Abstract: In this study, effective transport of small interfering RNAs (siRNAs) via hyaluronic acid (HA) receptor was carried out with biodegradable HA and low‐molecular weight polyethyleneimine (PEI)‐based transport systems. Gold nanoparticles (AuNPs) capable of giving photothermal… read more here.
Keywords: sirna using; delivery sirna; sirna; cxcr4 ... See more keywords
Direct Conjugation of Gallium-(III)-Corroles to short interfering RNA(siRNA) Providing Real-Time siRNA Imaging and Gene Silencing.
Sign Up to like & getrecommendations! Published in 2024 at "ChemPlusChem"
DOI: 10.1002/cplu.202400084
Abstract: Discovering new modifications for oligonucleotide therapeutics is essential for expanding its application to new targets and diseases. In this project, we focus on conjugating metaled ligands to short interfering RNAs (siRNAs) to investigate robust and… read more here.
Keywords: real time; iii; gene silencing; conjugation ... See more keywords
Inference from RNA interference: Suggestions to our authors
Sign Up to like & getrecommendations! Published in 2019 at "International Journal of Cancer"
DOI: 10.1002/ijc.32641
Abstract: Those of you who read Nature must have been astounded in 2008 about an article stating that “Non-targeted (against nonmammalian genes) and targeted (against Vegfa or Vegfr1) siRNA suppressed choroidal neovascularization via cell-surface toll-like receptor… read more here.
Keywords: inference rna; rna interference; suggestions authors; interference suggestions ... See more keywords