Dendrimer-siRNA Conjugates for Targeted Intracellular Delivery in Glioblastoma Animal Models.
Sign Up to like & getrecommendations! Published in 2022 at "ACS applied materials & interfaces"
DOI: 10.1021/acsami.2c13129
Abstract: Small interfering RNAs (siRNAs) are potent weapons for gene silencing, with an opportunity to correct defective genes and stop the production of undesirable proteins, with many applications in central nervous system (CNS) disorders. However, successful… read more here.
Keywords: sigfp; dendrimer sirna; sirna conjugates; intracellular delivery ... See more keywords
Antibody-siRNA conjugates: drugging the undruggable for anti-leukemic therapy
Sign Up to like & getrecommendations! Published in 2017 at "Expert Opinion on Biological Therapy"
DOI: 10.1080/14712598.2017.1273344
Abstract: ABSTRACT Introduction: Generating effective RNAi-based therapies with the potential to achieve leukemia remission remains critical unmet need. Despite a growing number of leukemia clinical trials, tissue specific delivery of therapeutic siRNA is a major roadblock… read more here.
Keywords: therapy antibody; sirna conjugates; antibody sirna; leukemic therapy ... See more keywords
From bench to bedside: Improving the clinical safety of GalNAc–siRNA conjugates using seed-pairing destabilization
Sign Up to like & getrecommendations! Published in 2022 at "Nucleic Acids Research"
DOI: 10.1093/nar/gkac539
Abstract: Abstract Preclinical mechanistic studies have pointed towards RNA interference-mediated off-target effects as a major driver of hepatotoxicity for GalNAc–siRNA conjugates. Here, we demonstrate that a single glycol nucleic acid or 2′–5′-RNA modification can substantially reduce… read more here.
Keywords: safety; seed pairing; sirna conjugates; galnac sirna ... See more keywords
Reductive nanocomplex encapsulation of cRGD-siRNA conjugates for enhanced targeting to cancer cells
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DOI: 10.2147/ijn.s136726
Abstract: In this study, through covalent conjugation and lipid material entrapment, a combined modification strategy was established for effective delivery of small interfering RNA (siRNA). Single strands of siRNA targeting to BRAFV600E gene (siMB3) conjugated with… read more here.
Keywords: sirna conjugates; bis crgd; crgd sirna; crgd ... See more keywords
The therapeutic prospects of N-acetylgalactosamine-siRNA conjugates
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Pharmacology"
DOI: 10.3389/fphar.2022.1090237
Abstract: RNA interference has become increasingly used for genetic therapy following the rapid development of oligonucleotide drugs. Significant progress has been made in its delivery system and implementation in the treatment of target organs. After a… read more here.
Keywords: prospects acetylgalactosamine; sirna conjugates; sirna; therapeutic prospects ... See more keywords