Histidine‐Engineered ZIF‐8 Nanoparticles for High‐Efficiency siRNA Delivery and Gene Therapy of Intervertebral Disc Degeneration
Sign Up to like & getrecommendations! Published in 2025 at "Advanced Functional Materials"
DOI: 10.1002/adfm.202504775
Abstract: Ferroptosis is a major contributor to intervertebral disc degeneration (IVDD) and represents a promising therapeutic target; however, effective medications that specifically target ferroptosis are still lacking. Consequently, strategies aimed at suppressing the expression of ferroptosis‐related… read more here.
Keywords: disc degeneration; intervertebral disc; sirna delivery; delivery ... See more keywords
Environment-Responsive Lipid/siRNA Nanoparticles for Cancer Therapy.
Sign Up to like & getrecommendations! Published in 2020 at "Advanced healthcare materials"
DOI: 10.1002/adhm.202001294
Abstract: RNA interference (RNAi) is a promising technology to regulate oncogenes for treating cancer. The primary limitation of siRNA for clinical application is the safe and efficacious delivery of therapeutic siRNA into target cells. Lipid-based delivery… read more here.
Keywords: sirna delivery; environment responsive; delivery; cancer ... See more keywords
Functional siRNA Delivery by Extracellular Vesicle-Liposome Hybrid Nanoparticles.
Sign Up to like & getrecommendations! Published in 2021 at "Advanced healthcare materials"
DOI: 10.1002/adhm.202101202
Abstract: The therapeutic use of RNA interference is limited by the inability of siRNA molecules to reach their site of action, the cytosol of target cells. Lipid nanoparticles, including liposomes, are commonly employed as siRNA carrier… read more here.
Keywords: functional sirna; sirna delivery; delivery extracellular; delivery ... See more keywords
Induced Self‐Assembly of Vitamin E‐Spermine/siRNA Nanocomplexes via Spermine/Helix Groove‐Specific Interaction for Efficient siRNA Delivery and Antitumor Therapy
Sign Up to like & getrecommendations! Published in 2024 at "Advanced Healthcare Materials"
DOI: 10.1002/adhm.202303186
Abstract: Gene therapy has been one of potential strategies for the treatment of different diseases, where efficient and safe gene delivery systems are also extremely in need. Current lipid nanoparticles (LNP) technology highly depends on the… read more here.
Keywords: sirna delivery; delivery; self assembled; spermine ... See more keywords
Engineered Chitosan‐Derived Nanocarrier for Efficient siRNA Delivery to Peripheral and Central Neurons
Sign Up to like & getrecommendations! Published in 2024 at "Advanced Healthcare Materials"
DOI: 10.1002/adhm.202500107
Abstract: Gene therapy using small interfering RNA (siRNA) holds promise for treating neurological disorders by silencing specific genes, such as the phosphatase and tensin homolog (PTEN) gene, which restricts axonal growth. Yet, delivering siRNA to neurons… read more here.
Keywords: delivery peripheral; sirna delivery; peripheral central; delivery ... See more keywords
Identification of Potent siRNA Delivery Peptides Using Computer Modeling
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DOI: 10.1002/advs.202308345
Abstract: Peptides with suitable aggregation behavior and electrical properties are potential siRNA delivery vectors. However, identifying suitable peptides with ideal delivery and safety features is difficult owing to the variations in amino acid sequences. Here, a… read more here.
Keywords: identification potent; computer modeling; sirna delivery; delivery ... See more keywords
Lymphocyte Membrane‐ and 12p1‐Dual‐Functionalized Nanoparticles for Free HIV‐1 Trapping and Precise siRNA Delivery into HIV‐1‐Infected Cells (Adv. Sci. 10/2023)
Sign Up to like & getrecommendations! Published in 2023 at "Advanced Science"
DOI: 10.1002/advs.202370058
Abstract: Precise siRNA Delivery Precise delivery of siRNA into HIV‐1‐infected cells is realized by the lymphocyte membraneand 12p1‐dual‐functionalized nanoparticles. These nanoparticles also display the ability of trapping free HIV‐1 and inhibiting the gp120‐induced bystander T cell… read more here.
Keywords: hiv; infected cells; hiv infected; precise sirna ... See more keywords
Genome-Wide CRISPR Screen Reveals PIK3CA Inhibition Enhances Lipid Nanoparticle-Mediated siRNA Delivery.
Sign Up to like & getrecommendations! Published in 2025 at "Advanced science"
DOI: 10.1002/advs.202517617
Abstract: Lipid nanoparticles (LNPs) are useful carriers for therapeutic siRNA delivery, yet their clinical efficacy remains constrained by insufficient cellular uptake. Here, using a genome-wide CRISPR knockout screen, multiple genetic modulators of LNP uptake is uncovered,… read more here.
Keywords: sirna delivery; genome wide; wide crispr; delivery ... See more keywords
Tumour‐derived extracellular vesicle membrane hybrid lipid nanovesicles enhance siRNA delivery by tumour‐homing and intracellular freeway transportation
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Extracellular Vesicles"
DOI: 10.1002/jev2.12198
Abstract: Abstract Extracellular vesicles (EVs) have been proved a promising small interfering RNA (siRNA) delivery vehicle to mediate gene‐silencing. Tumour‐derived extracellular vesicles (TDEVs) as genetic exchange vectors in the tumour microenvironment, enable intercellular communication for a… read more here.
Keywords: derived extracellular; tumour derived; membrane; delivery ... See more keywords
Flash Nanoprecipitation Fabrication of PEI@Amorphous Calcium Carbonate Hybrid Nanoparticles for siRNA Delivery.
Sign Up to like & getrecommendations! Published in 2023 at "Macromolecular bioscience"
DOI: 10.1002/mabi.202300085
Abstract: RNA interference (RNAi) is a promising approach for disease treatments. But the development of safe and effective delivery carriers remains a major challenge. Organic-inorganic hybrid nanoparticles (NPs), with the integration of functions from distinct materials,… read more here.
Keywords: hybrid nanoparticles; acc nps; amorphous calcium; calcium carbonate ... See more keywords
Combinatorial Synthesis of Alkyl Chain-Capped Poly(β-Amino Ester)s for Effective siRNA Delivery.
Sign Up to like & getrecommendations! Published in 2024 at "Macromolecular bioscience"
DOI: 10.1002/mabi.202400168
Abstract: Poly (β-amino ester) (PBAE) is a class of biodegradable polymers containing ester bonds in their main chain, extensively investigated as cationic polymer carriers for siRNA. Most current PBAE carriers rely on termination with hydrophilic or… read more here.
Keywords: sirna delivery; poly amino; delivery; alkyl chain ... See more keywords