Environment-Responsive Lipid/siRNA Nanoparticles for Cancer Therapy.
Sign Up to like & getrecommendations! Published in 2020 at "Advanced healthcare materials"
DOI: 10.1002/adhm.202001294
Abstract: RNA interference (RNAi) is a promising technology to regulate oncogenes for treating cancer. The primary limitation of siRNA for clinical application is the safe and efficacious delivery of therapeutic siRNA into target cells. Lipid-based delivery… read more here.
Keywords: sirna delivery; environment responsive; delivery; cancer ... See more keywords
Functional siRNA Delivery by Extracellular Vesicle-Liposome Hybrid Nanoparticles.
Sign Up to like & getrecommendations! Published in 2021 at "Advanced healthcare materials"
DOI: 10.1002/adhm.202101202
Abstract: The therapeutic use of RNA interference is limited by the inability of siRNA molecules to reach their site of action, the cytosol of target cells. Lipid nanoparticles, including liposomes, are commonly employed as siRNA carrier… read more here.
Keywords: functional sirna; sirna delivery; delivery extracellular; delivery ... See more keywords
Lymphocyte Membrane‐ and 12p1‐Dual‐Functionalized Nanoparticles for Free HIV‐1 Trapping and Precise siRNA Delivery into HIV‐1‐Infected Cells (Adv. Sci. 10/2023)
Sign Up to like & getrecommendations! Published in 2023 at "Advanced Science"
DOI: 10.1002/advs.202370058
Abstract: Precise siRNA Delivery Precise delivery of siRNA into HIV‐1‐infected cells is realized by the lymphocyte membraneand 12p1‐dual‐functionalized nanoparticles. These nanoparticles also display the ability of trapping free HIV‐1 and inhibiting the gp120‐induced bystander T cell… read more here.
Keywords: hiv; infected cells; hiv infected; precise sirna ... See more keywords
Tumour‐derived extracellular vesicle membrane hybrid lipid nanovesicles enhance siRNA delivery by tumour‐homing and intracellular freeway transportation
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Extracellular Vesicles"
DOI: 10.1002/jev2.12198
Abstract: Abstract Extracellular vesicles (EVs) have been proved a promising small interfering RNA (siRNA) delivery vehicle to mediate gene‐silencing. Tumour‐derived extracellular vesicles (TDEVs) as genetic exchange vectors in the tumour microenvironment, enable intercellular communication for a… read more here.
Keywords: derived extracellular; tumour derived; membrane; delivery ... See more keywords
Flash Nanoprecipitation Fabrication of PEI@Amorphous Calcium Carbonate Hybrid Nanoparticles for siRNA Delivery.
Sign Up to like & getrecommendations! Published in 2023 at "Macromolecular bioscience"
DOI: 10.1002/mabi.202300085
Abstract: RNA interference (RNAi) is a promising approach for disease treatments. But the development of safe and effective delivery carriers remains a major challenge. Organic-inorganic hybrid nanoparticles (NPs), with the integration of functions from distinct materials,… read more here.
Keywords: hybrid nanoparticles; acc nps; amorphous calcium; calcium carbonate ... See more keywords
Oxime Ether Lipids as Transfection Agents: Assembly and Complexation with siRNA.
Sign Up to like & getrecommendations! Published in 2017 at "Methods in molecular biology"
DOI: 10.1007/978-1-4939-7138-1_16
Abstract: RNAi-based therapeutic approaches to combat cancer and other diseases are currently an area of great interest. However, practical applications of this approach rely on optimal tools to carry and deliver siRNA to the desired site.… read more here.
Keywords: ether lipids; oxime ether; sirna delivery; lipids transfection ... See more keywords
Flow Cytometry-Based Cell Type-Specific Assessment of Target Regulation by Pulmonary siRNA Delivery.
Sign Up to like & getrecommendations! Published in 2019 at "Methods in molecular biology"
DOI: 10.1007/978-1-4939-9092-4_24
Abstract: Pulmonary siRNA delivery has attracted strong interest and has been reported to successfully mediate target gene knockdown in a number of disease models. However, the nature of the epithelial cells that eventually take up siRNA… read more here.
Keywords: sirna delivery; flow cytometry; cytometry based; cell ... See more keywords
The cutting-edge technologies of siRNA delivery and their application in clinical trials
Sign Up to like & getrecommendations! Published in 2018 at "Archives of Pharmacal Research"
DOI: 10.1007/s12272-018-1069-4
Abstract: AbstractsiRNA therapeutics allows precise regulation of disease specific gene expression to treat various diseases. Although gene silencing approaches using siRNA therapeutics shows some promising results in the treatment of gene-related diseases, the practical applications has… read more here.
Keywords: sirna delivery; cutting edge; delivery; edge technologies ... See more keywords
PEI fluorination reduces toxicity and promotes liver-targeted siRNA delivery
Sign Up to like & getrecommendations! Published in 2020 at "Drug Delivery and Translational Research"
DOI: 10.1007/s13346-020-00790-9
Abstract: Polyethyleneimine (PEI) has been extensively investigated as an efficient carrier for nucleic acid delivery. Yet, it suffers from a high toxicity profile that hinders clinical translation. Fluorination has proven to be a valid approach to… read more here.
Keywords: sirna delivery; delivery; fluorination; toxicity ... See more keywords
Highly antibacterial polypeptide-based amphiphilic copolymers as multifunctional non-viral vectors for enhanced intracellular siRNA delivery and anti-infection.
Sign Up to like & getrecommendations! Published in 2017 at "Acta biomaterialia"
DOI: 10.1016/j.actbio.2017.06.010
Abstract: For next-generation regenerative medicine and cancer therapy applications, the development of multifunctional biodegradable biomaterials with good antibacterial activity, biocompatibility and gene delivery capability is showing increased interests. As a natural cationic polypeptide, poly(ε-l-lysine) (EPL) has… read more here.
Keywords: delivery anti; sirna delivery; gene; sirna ... See more keywords
Strategies, design, and chemistry in siRNA delivery systems.
Sign Up to like & getrecommendations! Published in 2019 at "Advanced drug delivery reviews"
DOI: 10.1016/j.addr.2019.05.004
Abstract: Emerging therapeutics that utilize RNA interference (RNAi) have the potential to treat broad classes of diseases due to their ability to reversibly silence target genes. In August 2018, the FDA approved the first siRNA therapeutic,… read more here.
Keywords: sirna delivery; delivery; chemistry; delivery systems ... See more keywords