Near-Infrared Light-Triggered Polyprodrug/siRNA Loaded Upconversion Nanoparticles for Multi-Modality Imaging and Synergistic Cancer Therapy.
Sign Up to like & getrecommendations! Published in 2021 at "Advanced healthcare materials"
DOI: 10.1002/adhm.202100938
Abstract: Stimuli-responsive nanosystems have been widely applied as effective modalities for drug/gene co-delivery in cancer treatment. However, precise spatiotemporal manipulations of drug/gene co-delivery, as well as multi-modality imaging-guided cancer therapy, still remain a daunting challenge. Here,… read more here.
Keywords: polyprodrug sirna; sirna loaded; modality imaging; modality ... See more keywords
siRNA Loaded-Exosomes.
Sign Up to like & getrecommendations! Published in 2021 at "Methods in molecular biology"
DOI: 10.1007/978-1-0716-1298-9_21
Abstract: Exosomes are membrane-bound vesicles (40-100 nm) of endocytic origin released by numerous cell types that act as natural carriers of mRNA, microRNA, and proteins between cells. We developed a new system that uses intravenous injection of… read more here.
Keywords: exosomes sirna; loaded exosomes; sirna loaded; biology ... See more keywords
Engineering of Solid Dosage Forms of siRNA-Loaded Lipidoid-Polymer Hybrid Nanoparticles Using a Quality-by-Design Approach.
Sign Up to like & getrecommendations! Published in 2021 at "Methods in molecular biology"
DOI: 10.1007/978-1-0716-1298-9_9
Abstract: Therapy based on RNA interference (RNAi), which can be mediated by exogenous small interfering RNA (siRNA), has potential for the management of diseases at the genetic level by silencing gene function(s). In all eukaryotic cells,… read more here.
Keywords: sirna loaded; quality design; polymer; polymer hybrid ... See more keywords
Tips and Tools to Understand Direct Membrane Translocation of siRNA-Loaded WRAP-Based Nanoparticles.
Sign Up to like & getrecommendations! Published in 2022 at "Methods in molecular biology"
DOI: 10.1007/978-1-0716-1752-6_30
Abstract: Cell-penetrating peptide (CPP)-based approaches are excellent method for delivering cell-impermeable compounds/therapeutics such as proteins, antibodies, antisense oligonucleotides, siRNAs, plasmids, and drugs, as covalently or noncovalently conjugated cargo into cells. Nowadays, it is generally accepted that… read more here.
Keywords: sirna loaded; loaded wrap; translocation; based nanoparticles ... See more keywords
Downregulation of A2AR by siRNA loaded PEG-chitosan-lactate nanoparticles restores the T cell mediated anti-tumor responses through blockage of PKA/CREB signaling pathway.
Sign Up to like & getrecommendations! Published in 2019 at "International journal of biological macromolecules"
DOI: 10.1016/j.ijbiomac.2019.03.223
Abstract: Adenosine and its receptors are novel promising targets for cancer immunotherapy. In here, we aimed to evaluate the efficacy of Polyethylene glycol (PEG)-chitosan-lactate (PCL) nanoparticles (NPs) loaded with A2AR-specific siRNA for interfering with differentiation and… read more here.
Keywords: chitosan lactate; sirna loaded; a2ar sirna; sirna ... See more keywords
A targeted siRNA‐loaded PDL1‐exosome and functional evaluation against lung cancer
Sign Up to like & getrecommendations! Published in 2022 at "Thoracic Cancer"
DOI: 10.1111/1759-7714.14445
Abstract: As an endocytic nanosicle involved in intercellular communication, an exosome can efficiently deliver drugs from one cell to another and deliver therapeutic short interfering RNA (siRNA) to target cells. This is conducive to gene therapy… read more here.
Keywords: lung cancer; sirna loaded; targeted sirna; cancer targeted ... See more keywords
Aurora kinase B siRNA-loaded lactoferrin nanoparticles potentiate the efficacy of temozolomide in treating glioblastoma.
Sign Up to like & getrecommendations! Published in 2018 at "Nanomedicine"
DOI: 10.2217/nnm-2018-0110
Abstract: AIM To investigate the efficacy of lactoferrin nanoparticles (LfNPs) in delivering siRNA across the blood-brain barrier to treat glioblastoma multiforme (GBM) and with an additional objective of potentiation of conventional temozolomide (TMZ) chemotherapy. METHODS Aurora kinase… read more here.
Keywords: lactoferrin nanoparticles; sirna loaded; efficacy; akb lfnps ... See more keywords
Combining Inulin Multifunctional Polycation and Magnetic Nanoparticles: Redox-Responsive siRNA-Loaded Systems for Magnetofection
Sign Up to like & getrecommendations! Published in 2019 at "Polymers"
DOI: 10.3390/polym11050889
Abstract: Superparamagnetic Iron Oxide Nanoparticles (SPIONs) are recognized as one of the most promising agents for theranostic applications. Among methods designed for siRNA delivery, magnetofection, that is, nucleic acid cell uptake under the influence of a… read more here.
Keywords: sirna loaded; spions sirna; magnetofection; sirna ... See more keywords
Regulation on Toll-like Receptor 4 and Cell Barrier Function by Rab26 siRNA-loaded DNA Nanovector in Pulmonary Microvascular Endothelial Cells
Sign Up to like & getrecommendations! Published in 2017 at "Theranostics"
DOI: 10.7150/thno.17584
Abstract: The small GTPase Rab26 is involved in multiple processes, such as vesicle-mediated secretion and autophagy. However, the mechanisms and functions of Rab26 in the human pulmonary microvascular endothelial cells (HPMVECs) are not clear. In this… read more here.
Keywords: sirna loaded; microvascular endothelial; rab26 sirna; endothelial cells ... See more keywords
Suppressing Sart1 to modulate macrophage polarization by siRNA-loaded liposomes: a promising therapeutic strategy for pulmonary fibrosis
Sign Up to like & getrecommendations! Published in 2021 at "Theranostics"
DOI: 10.7150/thno.48152
Abstract: Idiopathic pulmonary fibrosis (IPF) is a chronic and diffuse form of interstitial lung disease of unknown etiology with a fatal outcome. Although various strategies for IPF have been developed over the last few decades, no… read more here.
Keywords: loaded liposomes; fibrosis; macrophage polarization; sirna loaded ... See more keywords