Controlled and sustained delivery of siRNA/NPs from hydrogels expedites bone fracture healing.
Sign Up to like & getrecommendations! Published in 2017 at "Biomaterials"
DOI: 10.1016/j.biomaterials.2017.06.001
Abstract: Despite great potential, delivery remains as the most significant barrier to the widespread use of siRNA therapeutics. siRNA has delivery limitations due to susceptibility to RNase degradation, low cellular uptake, and poor tissue-specific localization. Here,… read more here.
Keywords: delivery; fracture healing; sustained delivery; sirna nps ... See more keywords
Efficient Delivery of Therapeutic siRNA with Nanoparticles Induces Apoptosis in Prostate Cancer Cells
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Nanomaterials"
DOI: 10.1155/2018/4719790
Abstract: Gene silencing using small interfering RNA (siRNA) has shown significant potential in the treatment of cancer. Herein, we developed the lipid-polymer hybrid nanoparticles (PEG-LP/siRNA NPs) for siRNA delivery. The cell viability assay indicated that PEG-LP/siRNA… read more here.
Keywords: peg sirna; efficient delivery; cancer; sirna nps ... See more keywords
Dual pH-Responsive and Tumor-Targeted Nanoparticle-Mediated Anti-Angiogenesis siRNA Delivery for Tumor Treatment
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Nanomedicine"
DOI: 10.2147/ijn.s340926
Abstract: Purpose In order to overcome the biological barriers at all levels and enhance the delivery efficiency of siRNA, we have prepared a multifunctional siRNA delivery system (CHCE/siRNA nanoparticles) through self-assembly of the carboxymethyl chitosan modified… read more here.
Keywords: chce sirna; sirna; sirna nps; tumor ... See more keywords