Efficacy and Safety of Topical Sirolimus Therapy for Facial Angiofibromas in the Tuberous Sclerosis Complex: A Randomized Clinical Trial
Sign Up to like & getrecommendations! Published in 2017 at "JAMA Dermatology"
DOI: 10.1001/jamadermatol.2016.3545
Abstract: Importance Inhibitors of mammalian target of rapamycin complex 1, such as sirolimus, effectively target skin lesions in tuberous sclerosis complex (TSC). However, systemic treatment causes adverse effects, and topical sirolimus has shown promise in the… read more here.
Keywords: tuberous sclerosis; topical sirolimus; trial; treatment ... See more keywords
Propensity score matched all comers population treated with ultra‐thin strut bare metal and sirolimus‐probucol coated drug‐eluting stents of identical stent architecture
Sign Up to like & getrecommendations! Published in 2018 at "Catheterization and Cardiovascular Interventions"
DOI: 10.1002/ccd.27306
Abstract: The objective of this study was to compare the safety and efficacy of a polymer‐free sirolimus coated, ultrathin strut drug eluting stent (PF‐SES) to its uncoated bare‐metal stent (BMS) platform of identical stent architecture. read more here.
Keywords: drug eluting; identical stent; bare metal; stent architecture ... See more keywords
Nine‐month angiographic and 2‐year clinical outcomes of the RECOVERY trial: A randomized study of the biodegradable polymer sirolimus‐eluting COMBO dual‐therapy stent versus a polymer‐free sirolimus‐eluting stent in Chinese patients
Sign Up to like & getrecommendations! Published in 2021 at "Catheterization and Cardiovascular Interventions"
DOI: 10.1002/ccd.29553
Abstract: We evaluated the safety and efficacy of the novel dual‐therapy sirolimus‐eluting and endothelial progenitor cell (EPC) capture COMBO stent. read more here.
Keywords: dual therapy; sirolimus; sirolimus eluting; nine month ... See more keywords
Blue rubber bleb nevus syndrome: Promising response to sirolimus
Sign Up to like & getrecommendations! Published in 2017 at "Indian Pediatrics"
DOI: 10.1007/s13312-017-0998-1
Abstract: BackgroundBlue rubber bleb nevus syndrome is a rare disease involving venous malformations.Case characteristicsWe present a 6-year-old female with the syndrome, and consumptive coagulopathy.Intervention/OutcomeAfter management with sirolimus, symptoms resolved.MessageSirolimus may be a valuable option for reducing… read more here.
Keywords: nevus syndrome; rubber bleb; bleb nevus; blue rubber ... See more keywords
Blue rubber bleb nevus syndrome : un nouveau cas traité par sirolimus
Sign Up to like & getrecommendations! Published in 2018 at "Annales De Dermatologie Et De Venereologie"
DOI: 10.1016/j.annder.2018.03.015
Abstract: Introduction Le « blue rubber bleb nevus syndrome » (BRBNS), encore appele syndrome de Bean, caracterise par des malformations veineuses multifocales, essentiellement cutanees et gastro-intestinales [1] . Nous en rapportons un cas de localisation cutanee, digestive et… read more here.
Keywords: rubber bleb; par; avec; bleb nevus ... See more keywords
Effect of Converting From Calcineurin Inhibitor- to Sirolimus-Based Immunosuppressant Regimen on Breast Fibroadenoma Among Kidney Transplant Patients.
Sign Up to like & getrecommendations! Published in 2019 at "Transplantation proceedings"
DOI: 10.1016/j.transproceed.2019.04.040
Abstract: The incidence rate of breast fibroadenomas is higher among female kidney transplant (KT) patients treated using cyclosporine (CsA) for immunosuppression than in the general population. As such, there is an effort to convert immunosuppression from… read more here.
Keywords: transplant patients; kidney transplant; breast fibroadenoma; conversion ... See more keywords
Novel treatment of recurrent orbital venolymphatic malformation with sirolimus and rivaroxaban.
Sign Up to like & getrecommendations! Published in 2021 at "Orbit"
DOI: 10.1080/01676830.2021.1929339
Abstract: Orbital venolymphatic malformations are rare vascular malformations that typically appear early in life and harbor acute and chronic threats to vision. Historically, there are four categories of management: observation, medication, sclerotherapy, and surgery. Currently, there… read more here.
Keywords: orbital venolymphatic; novel treatment; sirolimus; venolymphatic malformation ... See more keywords
Sirolimus in the Treatment of Microcystic Lymphatic Malformations: A Systematic Review.
Sign Up to like & getrecommendations! Published in 2022 at "Lymphatic research and biology"
DOI: 10.1089/lrb.2021.0103
Abstract: Background: Genetic alterations in lymphatic development can lead to microcystic lymphatic malformations (micro LMs). LMs can have both microcystic and macrocytic components or be exclusively one or the other. LMs can result in serious, sometimes… read more here.
Keywords: sirolimus; systematic review; micro; lymphatic malformations ... See more keywords
Optimizing the clinical utility of sirolimus‐based immunosuppression for kidney transplantation
Sign Up to like & getrecommendations! Published in 2019 at "Clinical Transplantation"
DOI: 10.1111/ctr.13464
Abstract: While calcineurin inhibitors (CNIs) are effective for preventing acute rejection in kidney transplant recipients, long‐term use may cause chronic kidney injury and is associated with increased risks of cardiovascular events, cancer, and infection‐associated death. Immunosuppression… read more here.
Keywords: long term; sirolimus; transplantation; immunosuppression kidney ... See more keywords
Topical sirolimus for treatment of a solitary angiokeratoma
Sign Up to like & getrecommendations! Published in 2020 at "Dermatologic Therapy"
DOI: 10.1111/dth.13907
Abstract: Angiokeratomas are benign vascular neoplasms that arise as solitary or multiple lesions, most commonly treated with excision, electrodessication, cryotherapy, or laser therapies. This case presents a young female whose solitary angiokeratoma was treated with topical… read more here.
Keywords: topical sirolimus; treatment solitary; sirolimus; sirolimus treatment ... See more keywords
Topical sirolimus: Difference between compounded preparations and commercial oral solution
Sign Up to like & getrecommendations! Published in 2021 at "Pediatric Dermatology"
DOI: 10.1111/pde.14637
Abstract: Topical sirolimus has become a crucial treatment option for many dermatologic disorders. Because an FDA‐approved topical formulation is not commercially available, sirolimus creams, ointments, and gels are professionally prepared by compounding pharmacies. Also, the topical… read more here.
Keywords: topical sirolimus; oral solution; compounded preparations; sirolimus ... See more keywords