Efficacy and safety of sirolimus treatment for intractable lymphatic anomalies: A study protocol for an open-label, single-arm, multicenter, prospective study (SILA)
Sign Up to like & getrecommendations! Published in 2019 at "Regenerative Therapy"
DOI: 10.1016/j.reth.2018.12.001
Abstract: Introduction Lymphatic anomalies (LAs) refer to a group of diseases involving systemic dysplasia of lymphatic vessels. These lesions are classified as cystic lymphatic malformation (macrocystic, microcystic or mixed), generalized lymphatic anomaly, and Gorham–Stout disease. LAs… read more here.
Keywords: multicenter; treatment; treatment intractable; efficacy ... See more keywords
The use of sirolimus in the treatment of giant cystic lymphangioma
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DOI: 10.1097/md.0000000000008871
Abstract: Rationale: Lymphatic malformations (LMs) are rare and benign anomalies resulting from the defective embryological development of the primordial lymphatic structures. Due to their permeative growth throughout all tissue layers, treatment is often challenging. Small asymptomatic… read more here.
Keywords: use sirolimus; treatment; lymphangioma; sirolimus treatment ... See more keywords
Topical sirolimus for treatment of a solitary angiokeratoma
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DOI: 10.1111/dth.13907
Abstract: Angiokeratomas are benign vascular neoplasms that arise as solitary or multiple lesions, most commonly treated with excision, electrodessication, cryotherapy, or laser therapies. This case presents a young female whose solitary angiokeratoma was treated with topical… read more here.
Keywords: topical sirolimus; treatment solitary; sirolimus; sirolimus treatment ... See more keywords
Topical rapamycin (sirolimus) for the treatment of uncomplicated tufted angiomas in two children and review of the literature
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DOI: 10.1111/pde.13596
Abstract: The mTOR inhibitor rapamycin is used systemically for the treatment of vascular lesions. We report the first use of topical rapamycin for the successful treatment of two cases of tufted angioma. The evidence for the… read more here.
Keywords: topical rapamycin; treatment uncomplicated; rapamycin sirolimus; sirolimus treatment ... See more keywords
Successful Sirolimus Treatment for Korean Patients with Activated Phosphoinositide 3-kinase δ Syndrome 1: the First Case Series in Korea
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DOI: 10.3349/ymj.2020.61.6.542
Abstract: Activated phosphoinositide 3-kinase δ syndrome (APDS)1 is caused by gain-of-function mutations in PIK3CD, which encodes the catalytic p110δ subunit of phosphoinositide 3 kinase. We describe three patients with APDS1, the first thereof in Korea. Therein,… read more here.
Keywords: activated phosphoinositide; treatment; phosphoinositide kinase; sirolimus ... See more keywords