Silencing of SIRPα enhances the antitumor efficacy of CAR-M in solid tumors
Sign Up to like & getrecommendations! Published in 2024 at "Cellular and Molecular Immunology"
DOI: 10.1038/s41423-024-01220-3
Abstract: The potential of macrophage-mediated phagocytosis as a cancer treatment is promising. Blocking the CD47–SIRPα interaction with a CD47-specific antibody significantly enhances macrophage phagocytosis. However, concerns regarding their toxicity to nontumor cells remain substantial. Here, we… read more here.
Keywords: antitumor efficacy; efficacy car; solid tumors; car ... See more keywords
Surfactant protein D prevents mucin overproduction in airway goblet cells via SIRPα
Sign Up to like & getrecommendations! Published in 2024 at "Scientific Reports"
DOI: 10.1038/s41598-024-52328-5
Abstract: Mucin overproduction is a common feature of chronic airway diseases such as asthma and chronic obstructive pulmonary disease (COPD), and exacerbates their underlying respiratory condition. Surfactant protein D (SP-D) protects against airway diseases through modulation… read more here.
Keywords: sirp; mucin overproduction; surfactant protein; epithelial cells ... See more keywords
Discovery of high affinity, pan-allelic, and pan-mammalian reactive antibodies against the myeloid checkpoint receptor SIRPα
Sign Up to like & getrecommendations! Published in 2019 at "mAbs"
DOI: 10.1080/19420862.2019.1624123
Abstract: ABSTRACT Targeting the CD47-signal-regulatory protein α (SIRPα) pathway represents a novel therapeutic approach to enhance anti-cancer immunity by promoting both innate and adaptive immune responses. Unlike CD47, which is expressed ubiquitously, SIRPα expression is mainly… read more here.
Keywords: allelic pan; anti sirp; sirp antibodies; sirp ... See more keywords
Anti‐human SIRPα antibody is a new tool for cancer immunotherapy
Sign Up to like & getrecommendations! Published in 2018 at "Cancer Science"
DOI: 10.1111/cas.13548
Abstract: Interaction of signal regulatory protein α (SIRPα) expressed on the surface of macrophages with its ligand CD47 expressed on target cells negatively regulates phagocytosis of the latter cells by the former. We recently showed that… read more here.
Keywords: human sirp; sirp; anti human; cancer immunotherapy ... See more keywords
Preclinical characterization of the novel anti-SIRPα antibody BR105 that targets the myeloid immune checkpoint
Sign Up to like & getrecommendations! Published in 2022 at "Journal for Immunotherapy of Cancer"
DOI: 10.1136/jitc-2021-004054
Abstract: Background The CD47-SIRPα pathway acts as an important myeloid cell immune checkpoint and targeting the CD47/SIRPα axis represents a promising strategy to promote antitumor immunity. Several CD47-targeting agents show encouraging early activity in clinical trials.… read more here.
Keywords: antibody br105; immune checkpoint; sirp; cd47 ... See more keywords
BYON4228 is a pan-allelic antagonistic SIRPα antibody that potentiates destruction of antibody-opsonized tumor cells and lacks binding to SIRPγ on T cells
Sign Up to like & getrecommendations! Published in 2023 at "Journal for Immunotherapy of Cancer"
DOI: 10.1136/jitc-2022-006567
Abstract: Background Preclinical studies have firmly established the CD47-signal-regulatory protein (SIRP)α axis as a myeloid immune checkpoint in cancer, and this is corroborated by available evidence from the first clinical studies with CD47 blockers. However, CD47… read more here.
Keywords: byon4228; cell; pan allelic; sirp ... See more keywords
Abstract B077: Discovery and development of a highly differentiated, efficacious, first-in-class anti-SIRPα/β dual antibody with single agent phagocytosis activity
Sign Up to like & getrecommendations! Published in 2025 at "Molecular Cancer Therapeutics"
DOI: 10.1158/1535-7163.targ-25-b077
Abstract: The SIRPα-CD47 axis has emerged as a critical target in cancer therapy. While CD47-targeting agents have shown clinical promise, their widespread expression raises concerns about hematologic toxicities such as anaemia and thrombocytopenia, limiting their development.… read more here.
Keywords: cancer; antibody; dual antibody; phagocytosis ... See more keywords
SIRPα Mediates IGF1 Receptor in Cardiomyopathy Induced by Chronic Kidney Disease
Sign Up to like & getrecommendations! Published in 2022 at "Circulation Research"
DOI: 10.1161/circresaha.121.320546
Abstract: Background: Chronic kidney disease (CKD) is characterized by increased myocardial mass despite near-normal blood pressure, suggesting the presence of a separate trigger. A potential driver is SIRPα (signal regulatory protein alpha)—a mediator impairing insulin signaling.… read more here.
Keywords: insulin igf1r; muscle specific; sirp; ckd ... See more keywords
Ultrasound-responsive nanocarriers with siRNA and Fe3O4 regulate macrophage polarization and phagocytosis for augmented non-small cell lung cancer immunotherapy
Sign Up to like & getrecommendations! Published in 2024 at "Journal of Nanobiotechnology"
DOI: 10.1186/s12951-024-02883-w
Abstract: The immunosuppressive tumor microenvironment (TME) significantly inhibits the effective anti-tumor immune response, greatly affecting the efficacy of immunotherapy. Most tumor-associated macrophages (TAMs) belong to the M2 phenotype, which contributes significantly to the immunosuppressive effects in… read more here.
Keywords: cancer; non small; small cell; phagocytosis ... See more keywords
Safety, pharmacokinetics, efficacy, and preliminary biomarker data of first-in-class BI 765063, a selective SIRPα inhibitor: Results of monotherapy dose escalation in phase 1 study in patients with advanced solid tumors.
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Clinical Oncology"
DOI: 10.1200/jco.2021.39.15_suppl.2623
Abstract: 2623 Background: BI 765063 is a humanized IgG4 monoclonal antibody antagonist of SIRPα (Signal Regulatory Protein α), which blocks the “don't eat me” signal of the SIRPα/CD47 axis, a critical innate immune checkpoint. SIRPα is… read more here.
Keywords: patients advanced; advanced solid; dose escalation; sirp ... See more keywords
Blockade of SIRPα-CD47 axis by anti-SIRPα antibody enhances anti-tumor activity of DXd antibody-drug conjugates
Sign Up to like & getrecommendations! Published in 2024 at "PLOS ONE"
DOI: 10.1371/journal.pone.0304985
Abstract: Signal regulatory protein alpha (SIRPα) is an immune inhibitory receptor on myeloid cells including macrophages and dendritic cells, which binds to CD47, a ubiquitous self-associated molecule. SIRPα-CD47 interaction is exploited by cancer cells to suppress… read more here.
Keywords: sirp; dxd; anti tumor; sirp cd47 ... See more keywords