Platinum(IV) complexes as inhibitors of CD47-SIRPα axis for chemoimmunotherapy of cancer.
Sign Up to like & getrecommendations! Published in 2021 at "European journal of medicinal chemistry"
DOI: 10.1016/j.ejmech.2021.114047
Abstract: Phagocytosis of cancer cells by antigen presenting cells (APCs) is critical to activate the host's immune responses. However, the targeting ability of APCs to cancer cells is limited by the upregulation of transmembrane protein CD47… read more here.
Keywords: cancer; cancer cells; cd47 sirp; platinum complexes ... See more keywords
Recent Advances of Tumor Therapy Based on the CD47-SIRPα Axis.
Sign Up to like & getrecommendations! Published in 2022 at "Molecular pharmaceutics"
DOI: 10.1021/acs.molpharmaceut.2c00073
Abstract: Cancer is still a major disease that is currently difficult for humans to overcome. When the expression of the cluster of differentiation 47 (CD47) is upregulated, tumor cells interact with the macrophage inhibitory receptor signal… read more here.
Keywords: advances tumor; therapy; cd47; cd47 sirp ... See more keywords
Blockade of the CD47-SIRPα axis: a promising approach for cancer immunotherapy
Sign Up to like & getrecommendations! Published in 2019 at "Expert Opinion on Biological Therapy"
DOI: 10.1080/14712598.2020.1685976
Abstract: Macrophages are often the most abundant immune cell found in the tumor microenvironment, but are frequently associated with poor patient prognosis and considered detrimental to mounting an effectiv... read more here.
Keywords: sirp axis; blockade cd47; axis promising; promising approach ... See more keywords