SIRPα-CD47 Blockade-Mediated Tumor Cell Phagocytosis Requires SLAMF7.
Sign Up to like & getrecommendations! Published in 2017 at "Cancer discovery"
DOI: 10.1158/2159-8290.cd-rw2017-081
Abstract: SLAMF7 expression is required for macrophage-mediated phagocytosis of hematopoietic tumor cells. read more here.
Keywords: mediated tumor; phagocytosis; blockade mediated; cd47 blockade ... See more keywords
Effects of TTI-621 (SIRPαFc) on CD47 and serum cytokines associated with phagocytosis in subjects with relapsed, refractory hematologic malignancies: Pharmacodynamic findings from a first-in-human clinical trial.
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Clinical Oncology"
DOI: 10.1200/jco.2017.35.7_suppl.112
Abstract: 112Background: CD47 delivers an anti-phagocytic (“do not eat”) signal by binding SIRPα on macrophages and is overexpressed on many cancers enabling immune surveillance evasion. TTI-621 is a decoy receptor that promotes phagocytosis of tumors by… read more here.
Keywords: tti 621; 621 sirp; cd47; effects tti ... See more keywords
A homogeneous SIRPα-CD47 cell-based, ligand-binding assay: Utility for small molecule drug development in immuno-oncology
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DOI: 10.1371/journal.pone.0226661
Abstract: CD47 is an immune checkpoint protein that downregulates both the innate and adaptive anti-tumor immune response via its counter receptor SIRPα. Biologics, including humanized CD47 monoclonal antibodies and decoy SIRPα receptors, that block the SIRPα-CD47… read more here.
Keywords: cell based; cd47; sirp cd47; oncology ... See more keywords