Blockade of CD47-SirpĪ± Interactions Improved Myeloid Effector Cell Mediated Lymphoma Cell Killing By the HLA-DR Antibody Apolizumab
Sign Up to like & getrecommendations! Published in 2019 at "Blood"
DOI: 10.1182/blood-2019-122940
Abstract: Background:Apolizumab (APO) is a humanized IgG1 antibody targeting a HLA-DRĪ² chain specific epitope, which is expressed by approx. 50 % of B cell lymphomas. The antibody's clinical development was hampered by toxicity, potentially mediated by… read more here.
Keywords: lymphoma; cell; sirp interactions; cd47 sirp ... See more keywords