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Anomalous Levels of CD47/Signal Regulatory Protein Alpha in the Hippocampus Lead to Excess Microglial Engulfment in Mouse Model of Perioperative Neurocognitive Disorders

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Published in 2022 at "Frontiers in Neuroscience"

DOI: 10.3389/fnins.2022.788675

Abstract: Background Perioperative neurocognitive disorders (PNDs) are common complications of surgical patients, which can lead to prolonged hospitalization, increased complications, and decreased independence and quality of life. However, the underlying molecular mechanisms of PND remain largely… read more here.

Keywords: sirp overexpression; engulfment; sirp; expression ... See more keywords