CD47 Ligation Repositions the Inhibitory Receptor SIRPA to Suppress Integrin Activation and Phagocytosis.
Sign Up to like & getrecommendations! Published in 2020 at "Immunity"
DOI: 10.1016/j.immuni.2020.07.008
Abstract: CD47 acts as a "don't eat me" signal that protects cells from phagocytosis by binding and activating its receptor SIPRA on macrophages. CD47 suppresses multiple different pro-engulfment "eat me" signals, including immunoglobulin G (IgG), complement,… read more here.
Keywords: phagocytosis; cd47; cd47 ligation; sirpa ... See more keywords
Signal regulatory protein alpha is a conserved marker for mouse and rat spermatogonial stem cells
Sign Up to like & getrecommendations! Published in 2023 at "Biology of Reproduction"
DOI: 10.1093/biolre/ioad006
Abstract: Abstract Characterization of spermatogonial stem cells (SSCs) has been hampered by their low frequency and lack of features that distinguish them from committed spermatogonia. Few conserved SSC markers have been discovered. To identify a new… read more here.
Keywords: mouse rat; marker; spermatogonial stem; stem cells ... See more keywords
High SIRPA Expression Predicts Poor Prognosis and Correlates with Immune Infiltrates in Patients with Esophageal Carcinoma
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DOI: 10.1155/2022/3565676
Abstract: Background Signal regulatory protein alpha (SIRPA) is an inhibitory receptor expressed in macrophages and a potential therapeutic target in cancers. This study aims to investigate the functional role of SIRPA in esophageal carcinoma (ESCA). Methods… read more here.
Keywords: immune infiltrates; expression; esophageal carcinoma; sirpa expression ... See more keywords
Signal-regulatory protein alpha is an anti-viral entry factor targeting viruses using endocytic pathways
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DOI: 10.1371/journal.ppat.1009662
Abstract: Signal-regulatory protein alpha (SIRPA) is a well-known inhibitor of phagocytosis when it complexes with CD47 expressed on target cells. Here we show that SIRPA decreased in vitro infection by a number of pathogenic viruses, including… read more here.
Keywords: anti viral; signal regulatory; regulatory protein; sirpa ... See more keywords