Regulation of radiation‐induced liver damage by modulation of SIRT‐1 activity: In vivo rat model
Sign Up to like & getrecommendations! Published in 2022 at "Cell Biochemistry and Function"
DOI: 10.1002/cbf.3762
Abstract: Silent information regulator 1 (SIRT‐1), a nicotinamide adenine dinucleotide‐dependent deacetylase, was found to regulate cell apoptosis, inflammation, and oxidative stress response in living organisms. Therefore, the role of SIRT‐1 in regulating forkhead box O/poly ADP‐ribose… read more here.
Keywords: liver damage; sirt activity; sirt; activity ... See more keywords
Live-Cell Imaging of Sirtuin Activity Using a One-Step Fluorescence Probe.
Sign Up to like & getrecommendations! Published in 2021 at "Methods in molecular biology"
DOI: 10.1007/978-1-0716-1258-3_14
Abstract: Sirtuins (SIRTs) are a family of NAD+-dependent histone deacetylases (HDACs). In mammals, dysfunction of SIRTs is associated with age-related metabolic diseases, cancers, and even aging. Therefore, the detection of SIRT activity in living cells or… read more here.
Keywords: fluorescence probe; sirt; activity; live cell ... See more keywords
DNA lesions correlate with lymphocyte function after selective internal radiotherapy
Sign Up to like & getrecommendations! Published in 2019 at "Cancer Immunology, Immunotherapy"
DOI: 10.1007/s00262-019-02323-x
Abstract: In patients with non-resectable hepatic malignancies selective internal radiotherapy (SIRT) with yttrium-90 is an effective therapy. However, previous data indicate that SIRT leads to impaired immune function. The aim of the current study was to… read more here.
Keywords: internal radiotherapy; dna; sirt; dna lesions ... See more keywords
In Vivo Comparison of Micro-Balloon Interventions (MBI) Advantage: A Retrospective Cohort Study of DEB-TACE Versus b-TACE and of SIRT Versus b-SIRT
Sign Up to like & getrecommendations! Published in 2022 at "CardioVascular and Interventional Radiology"
DOI: 10.1007/s00270-021-03035-5
Abstract: The purpose of this study was to evaluate in vivo the role of the micro-balloon by comparing trans-arterial chemoembolization (DEB-TACE) and selective internal radiotherapy (SIRT) procedures performed with and without balloon micro-catheter (b-DEB-TACE and DEB-TACE/SIRT… read more here.
Keywords: tace; sirt; balloon; deb tace ... See more keywords
Dihydromyricetin Improves Mitochondrial Biogenesis in the Liver of Alcohol Fed Mice via the AMPK/Sirt-1/PGC-1α Signaling Axis.
Sign Up to like & getrecommendations! Published in 2020 at "Alcohol"
DOI: 10.1016/j.alcohol.2020.10.002
Abstract: Alcoholic liver disease (ALD), due to the multifactorial damage associated with alcohol (ethanol/EtOH) consumption and metabolism, is one of the most prevalent liver diseases in the United States. The liver is the primary site of… read more here.
Keywords: mitochondrial biogenesis; sirt; liver; fed mice ... See more keywords
Intra arterial treatment of hepatocellular carcinoma: Comparison of MELD score variations between radio-embolization and chemo-embolization.
Sign Up to like & getrecommendations! Published in 2019 at "Diagnostic and interventional imaging"
DOI: 10.1016/j.diii.2019.05.006
Abstract: PURPOSE The purpose of this study was to assess liver function deterioration, as assessed using the model for end-stage liver disease (MELD) score variations, following transarterial chemo-embolization (TACE) versus selective internal radiation therapy (SIRT) in… read more here.
Keywords: tace; treatment; sirt; embolization ... See more keywords
SIRT3, a modifier of mitochondrial function in Huntington's disease
Sign Up to like & getrecommendations! Published in 2018 at "Free Radical Biology and Medicine"
DOI: 10.1016/j.freeradbiomed.2018.04.072
Abstract: SIRT 3 is the major regulator of the mitochondrial acetylome, mediating adaptive responses of neurons to metabolic challenges. Here, we speculated that targeting SIRT 3 might influence mitochondrial function and oxidative status that are abnormal… read more here.
Keywords: mitochondrial function; sirt; sirt3 modifier; huntington disease ... See more keywords
Activation of AMPK-dependent SIRT-1 by astragalus polysaccharide protects against ochratoxin A-induced immune stress in vitro and in vivo.
Sign Up to like & getrecommendations! Published in 2018 at "International journal of biological macromolecules"
DOI: 10.1016/j.ijbiomac.2018.08.156
Abstract: Recent studies have highlighted the immune stress caused by ochratoxin A (OTA), but little attention was paid to its alleviation. In the present study, the protective effects of astragalus polysaccharide (APS) against OTA-induced immune stress… read more here.
Keywords: immune stress; sirt; vitro vivo;
Stereotactic body radiation therapy (SBRT) following Yttrium-90 (90Y) selective internal radiation therapy (SIRT): a feasibility planning study using 90Y delivered dose
Sign Up to like & getrecommendations! Published in 2023 at "Physics in Medicine and Biology"
DOI: 10.1088/1361-6560/acbbb5
Abstract: Objective. 90Y selective internal radiation therapy (SIRT) treatment of hepatocellular carcinoma (HCC) can potentially underdose lesions, as identified on post-therapy PET/CT imaging. This study introduces a methodology and explores the feasibility for selectively treating SIRT-underdosed… read more here.
Keywords: methodology; sbrt; therapy; sirt ... See more keywords
Incidental Finding of Pulmonary Embolism at Workup Before SIRT.
Sign Up to like & getrecommendations! Published in 2021 at "Clinical nuclear medicine"
DOI: 10.1097/rlu.0000000000003883
Abstract: ABSTRACT Selective internal radiation therapy (SIRT) is a catheter-guided treatment offered to selected patients with primary and secondary liver malignancies. SIRT is preceded by a workup procedure, where 99mTc-MAA (macroaggregated albumin) is injected in the… read more here.
Keywords: sirt; embolism workup; pulmonary embolism; finding pulmonary ... See more keywords
Effect of phylloquinone on indomethacin‐induced gastric ulceration in rats: Role of SIRT‐1
Sign Up to like & getrecommendations! Published in 2023 at "Clinical and Experimental Pharmacology and Physiology"
DOI: 10.1111/1440-1681.13752
Abstract: Gastric ulcer is the most common gastrointestinal disorder affecting people globally. Although many drugs are available to treat ulcers, the mortality rate is relatively high, and drugs lack selectivity to treat ulcers without causing side… read more here.
Keywords: phylloquinone; sirt; indomethacin induced; induced gastric ... See more keywords