SRT1720‐induced activation of SIRT1 alleviates vascular smooth muscle cell senescence through PKA‐dependent phosphorylation of AMPKα at Ser485
Sign Up to like & getrecommendations! Published in 2020 at "FEBS Open Bio"
DOI: 10.1002/2211-5463.12895
Abstract: Aging is a major risk factor for hypertension and atherosclerosis, and vascular smooth muscle cell (VSMC) senescence can promote aging‐related vascular diseases. Sirtuin‐1 (SIRT1) and AMP‐activated protein kinase (AMPK) were previously reported to modulate vascular… read more here.
Keywords: sirt1; ampk ser485; senescence; ampk ... See more keywords
The Sirt1‐Piezo1 Axis Promotes Bone Formation and Repair in Mice
Sign Up to like & getrecommendations! Published in 2025 at "Advanced Science"
DOI: 10.1002/advs.202510103
Abstract: The mechanosensitive Piezo1 channel protein plays a pivotal role in promoting bone formation and repair; however, its underlying molecular mechanism(s) are poorly defined. Here this study shows that Sirt1 positively regulates Piezo1 expression and activity… read more here.
Keywords: repair; formation repair; bone formation; sirt1 ... See more keywords
SIRT1/Notch1 signal axis involves in the promoting effect of Segetalin B on bone formation
Sign Up to like & getrecommendations! Published in 2022 at "Drug Development Research"
DOI: 10.1002/ddr.22001
Abstract: Phytoestrogens are a class of potential natural medicines for treating postmenopausal osteoporosis (PMOP). Segetalin B (SB) is a cyclic peptide compound showing estrogenic activity. This study reports the effect of SB on bone formation among… read more here.
Keywords: bone formation; ovx rats; effect; bone ... See more keywords
LncRNA Snhg8 attenuates microglial inflammation response and blood–brain barrier damage in ischemic stroke through regulating miR‐425‐5p mediated SIRT1/NF‐κB signaling
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Biochemical and Molecular Toxicology"
DOI: 10.1002/jbt.22724
Abstract: Increasing studies have indicated that abnormal expressed long noncoding RNAs (lncRNAs) play a vital role in ischemic stroke. Small nucleolar RNA host gene 8 (Snhg8), a member of lncRNAs, has been found to induce neuronal… read more here.
Keywords: sirt1; microglial inflammation; mir 425; inflammation ... See more keywords
Knockdown of long non‐coding RNA ANRIL inhibits proliferation, migration, and invasion but promotes apoptosis of human glioma cells by upregulation of miR‐34a
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Cellular Biochemistry"
DOI: 10.1002/jcb.26437
Abstract: Gliomas are the most common types of primary central nervous system malignancy found in adults. Long non‐coding RNA antisense non‐coding RNA in the INK4 locus (ANRIL) variants are associated with glioma and miR‐34a is markedly… read more here.
Keywords: sirt1; glioma; mir 34a; proliferation ... See more keywords
SIRT1 in Aging and Diseases
Sign Up to like & getrecommendations! Published in 2025 at "Journal of Cellular Biochemistry"
DOI: 10.1002/jcb.70069
Abstract: Sirtuin 1 (SIRT1) is a NAD+‐dependent deacetylase belonging to the sirtuin family, which regulates a broad spectrum of cellular processes through deacetylation of both histones in the nucleus and non‐histone proteins in the cytosol. Accumulating… read more here.
Keywords: sirt1 aging; biochemistry; sirt1; aging diseases ... See more keywords
The role of SIRT1 in skeletal muscle function and repair of older mice
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Cachexia, Sarcopenia and Muscle"
DOI: 10.1002/jcsm.12437
Abstract: Sirtuin 1 (SIRT1) is a NAD+ sensitive deacetylase that has been linked to longevity and has been suggested to confer beneficial effects that counter aging‐associated deterioration. Muscle repair is dependent upon satellite cell function, which… read more here.
Keywords: sirt1; muscle; older mice; muscle function ... See more keywords
SIRT1 inhibition-induced senescence as a strategy to prevent prostate cancer progression.
Sign Up to like & getrecommendations! Published in 2022 at "Molecular carcinogenesis"
DOI: 10.1002/mc.23412
Abstract: Emerging evidence suggests an important role for SIRT1, a nicotinamide adenine dinucleotide (NAD)-dependent deacetylase in cancer development, progression and therapeutic resistance; making it a viable therapeutic target. Here, we examined the impact of resveratrol-mediated pharmacological… read more here.
Keywords: senescence; development; progression; cancer ... See more keywords
Discovery of small molecule sirt1 activator using high-throughput virtual screening, molecular dynamics simulation, molecular mechanics generalized born/surface area (MM/GBSA) calculation, and biological evaluation
Sign Up to like & getrecommendations! Published in 2019 at "Medicinal Chemistry Research"
DOI: 10.1007/s00044-019-02479-2
Abstract: Sirt1, namely silent information regulator 1, belongs to a highly conserved family of NAD+-dependent deacetylase which is involved in innumerable human disorders such as obesity, type 2 diabetes, cancer, and aging. Combined high-throughput virtual screening,… read more here.
Keywords: sirt1; throughput virtual; virtual screening; simulation ... See more keywords
Canagliflozin potentially promotes renal protection against glycerol-induced acute kidney injury by activating the AMPK/SIRT1/FOXO-3a/PGC-1α and Nrf2/HO-1 pathways
Sign Up to like & getrecommendations! Published in 2025 at "Naunyn-Schmiedeberg's Archives of Pharmacology"
DOI: 10.1007/s00210-025-04017-x
Abstract: The reno-protective potential of canagliflozin (Cana), an inhibitor of the sodium glucose–linked co-transporter-2 (SGLT-2), has been demonstrated in different models of kidney injury. However, its potential role in preventing glycerol (Gly)-induced acute kidney injury (AKI)… read more here.
Keywords: kidney injury; cana; sirt1; pgc ... See more keywords
The role of resveratrol, Sirtuin1 and RXRα as prognostic markers in ovarian cancer
Sign Up to like & getrecommendations! Published in 2021 at "Archives of Gynecology and Obstetrics"
DOI: 10.1007/s00404-021-06262-w
Abstract: Ovarian cancer is the most lethal gynecologic cancer. Resveratrol (RSV) is known to alter metabolism in cancer. It affects the nuclear retinoid-X-receptor (RXR), which implies a modulating effect of RXR to gynaecologic cancers. Furthermore, RSV… read more here.
Keywords: cancer; expression; sirt1; resveratrol ... See more keywords