SRT1720‐induced activation of SIRT1 alleviates vascular smooth muscle cell senescence through PKA‐dependent phosphorylation of AMPKα at Ser485
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DOI: 10.1002/2211-5463.12895
Abstract: Aging is a major risk factor for hypertension and atherosclerosis, and vascular smooth muscle cell (VSMC) senescence can promote aging‐related vascular diseases. Sirtuin‐1 (SIRT1) and AMP‐activated protein kinase (AMPK) were previously reported to modulate vascular… read more here.
Keywords: sirt1; ampk ser485; senescence; ampk ... See more keywords
SIRT1/Notch1 signal axis involves in the promoting effect of Segetalin B on bone formation
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DOI: 10.1002/ddr.22001
Abstract: Phytoestrogens are a class of potential natural medicines for treating postmenopausal osteoporosis (PMOP). Segetalin B (SB) is a cyclic peptide compound showing estrogenic activity. This study reports the effect of SB on bone formation among… read more here.
Keywords: bone formation; ovx rats; effect; bone ... See more keywords
LncRNA Snhg8 attenuates microglial inflammation response and blood–brain barrier damage in ischemic stroke through regulating miR‐425‐5p mediated SIRT1/NF‐κB signaling
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DOI: 10.1002/jbt.22724
Abstract: Increasing studies have indicated that abnormal expressed long noncoding RNAs (lncRNAs) play a vital role in ischemic stroke. Small nucleolar RNA host gene 8 (Snhg8), a member of lncRNAs, has been found to induce neuronal… read more here.
Keywords: sirt1; microglial inflammation; mir 425; inflammation ... See more keywords
Knockdown of long non‐coding RNA ANRIL inhibits proliferation, migration, and invasion but promotes apoptosis of human glioma cells by upregulation of miR‐34a
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DOI: 10.1002/jcb.26437
Abstract: Gliomas are the most common types of primary central nervous system malignancy found in adults. Long non‐coding RNA antisense non‐coding RNA in the INK4 locus (ANRIL) variants are associated with glioma and miR‐34a is markedly… read more here.
Keywords: sirt1; glioma; mir 34a; proliferation ... See more keywords
The role of SIRT1 in skeletal muscle function and repair of older mice
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DOI: 10.1002/jcsm.12437
Abstract: Sirtuin 1 (SIRT1) is a NAD+ sensitive deacetylase that has been linked to longevity and has been suggested to confer beneficial effects that counter aging‐associated deterioration. Muscle repair is dependent upon satellite cell function, which… read more here.
Keywords: sirt1; muscle; older mice; muscle function ... See more keywords
SIRT1 inhibition-induced senescence as a strategy to prevent prostate cancer progression.
Sign Up to like & getrecommendations! Published in 2022 at "Molecular carcinogenesis"
DOI: 10.1002/mc.23412
Abstract: Emerging evidence suggests an important role for SIRT1, a nicotinamide adenine dinucleotide (NAD)-dependent deacetylase in cancer development, progression and therapeutic resistance; making it a viable therapeutic target. Here, we examined the impact of resveratrol-mediated pharmacological… read more here.
Keywords: senescence; development; progression; cancer ... See more keywords
Discovery of small molecule sirt1 activator using high-throughput virtual screening, molecular dynamics simulation, molecular mechanics generalized born/surface area (MM/GBSA) calculation, and biological evaluation
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DOI: 10.1007/s00044-019-02479-2
Abstract: Sirt1, namely silent information regulator 1, belongs to a highly conserved family of NAD+-dependent deacetylase which is involved in innumerable human disorders such as obesity, type 2 diabetes, cancer, and aging. Combined high-throughput virtual screening,… read more here.
Keywords: sirt1; throughput virtual; virtual screening; simulation ... See more keywords
The role of resveratrol, Sirtuin1 and RXRα as prognostic markers in ovarian cancer
Sign Up to like & getrecommendations! Published in 2021 at "Archives of Gynecology and Obstetrics"
DOI: 10.1007/s00404-021-06262-w
Abstract: Ovarian cancer is the most lethal gynecologic cancer. Resveratrol (RSV) is known to alter metabolism in cancer. It affects the nuclear retinoid-X-receptor (RXR), which implies a modulating effect of RXR to gynaecologic cancers. Furthermore, RSV… read more here.
Keywords: cancer; expression; sirt1; resveratrol ... See more keywords
Reduced serum SIRT1 levels in patients with Parkinson’s disease: a cross-sectional study in China
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DOI: 10.1007/s10072-020-04711-z
Abstract: Parkinson’s disease (PD) is a movement disorder lacking of validated biomarkers. Experimental studies support the potential value of silent information regulator 1 (SIRT1) in neurodegeneration including PD. We aim to detect the serum levels of… read more here.
Keywords: sirt1; reduced serum; study; serum sirt1 ... See more keywords
Smooth Muscle Sirtuin 1 Blocks Thoracic Aortic Aneurysm/Dissection Development in Mice
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DOI: 10.1007/s10557-020-07005-w
Abstract: Purpose Advancing age is the major risk factor for thoracic aortic aneurysm/dissection (TAAD). However, the causative link between age-related molecules and TAAD remains elusive. Here, we investigated the role of Sirtuin 1 (SIRT1, also known… read more here.
Keywords: sirt1; thoracic aortic; expression; smooth muscle ... See more keywords
Chikusetsusaponin V Inhibits LPS-Activated Inflammatory Responses via SIRT1/NF-κB Signaling Pathway in RAW264.7 Cells
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DOI: 10.1007/s10753-018-0858-8
Abstract: It is becoming increasingly accepted that macrophage activation play a crucial role in many diseases associated with chronic inflammation, such as metabolic disease, including atherosclerosis, obesity, and diabetes. Recent studies have indicated that the regulation… read more here.
Keywords: sirt1; sirt1 signaling; lps induced; csv ... See more keywords