Omega-7 inhibits inflammation and promotes collagen synthesis through SIRT1 activation
Sign Up to like & getrecommendations! Published in 2018 at "Applied Biological Chemistry"
DOI: 10.1007/s13765-018-0377-1
Abstract: Excessive accumulation of reactive oxygen species (ROS) during oxidative stress accelerates the skin aging process. ROS stimulate inflammatory processes in the skin, leading to activation of matrix metalloprotease-1 (MMP-1). Silent information regulator 1 (SIRT1) controls… read more here.
Keywords: sirt1; collagen; sirt1 activation; hacat cells ... See more keywords
SIRT1 activation promotes angiogenesis in diabetic wounds by protecting endothelial cells against oxidative stress.
Sign Up to like & getrecommendations! Published in 2019 at "Archives of biochemistry and biophysics"
DOI: 10.1016/j.abb.2018.11.016
Abstract: OBJECTIVE Chronic wounds are a devastating complication of diabetes and can lead to amputations or even death. Current medical therapies are insufficient to accelerate its repair. The objective of this study was to explore the… read more here.
Keywords: sirt1; sirt1 activation; endothelial cells; oxidative stress ... See more keywords
SIRT1 Activation Disrupts Maintenance of Myelodysplastic Syndrome Stem and Progenitor Cells by Restoring TET2 Function.
Sign Up to like & getrecommendations! Published in 2018 at "Cell stem cell"
DOI: 10.1016/j.stem.2018.07.018
Abstract: Myelodysplastic syndrome (MDS), a largely incurable hematological malignancy, is derived from aberrant clonal hematopoietic stem/progenitor cells (HSPCs) that persist after conventional therapies. Defining the mechanisms underlying MDS HSPC maintenance is critical for developing MDS therapy.… read more here.
Keywords: sirt1; sirt1 activation; tet2; myelodysplastic syndrome ... See more keywords
Forsythoside B alleviates cerebral ischemia-reperfusion injury via inhibiting NLRP3 inflammasome mediated by SIRT1 activation
Sign Up to like & getrecommendations! Published in 2024 at "PLOS ONE"
DOI: 10.1371/journal.pone.0305541
Abstract: Background The inflammatory response is a key factor in the pathogenesis of cerebral ischemia/reperfusion injury (CIRI), and anti-inflammatory interventions may offer a promising therapeutic strategy. Forsythoside B (FB) is a phenylethanoid glycoside isolated from Forsythiae… read more here.
Keywords: sirt1 activation; ischemia reperfusion; cerebral ischemia; activation ... See more keywords
Biotechnological Elucidation of Xinyin Tablet’s Mechanism: SIRT1 Activation Attenuates Cardiac Fibrosis Via Suppressing Endothelial-to-Mesenchymal Transition
Sign Up to like & getrecommendations! Published in 2025 at "Iranian Journal of Biotechnology"
DOI: 10.30498/ijb.2025.510746.4086
Abstract: Background: Xinyin tablet (XYT), a traditional Chinese medicine consisting of Ginseng, Ophiopogon, Astragalus, Ilex pubescens, Motherwort, and other medicines, is clinically used to manage chronic heart failure (HF), yet its molecular mechanisms remain underexplored. Objectives:… read more here.
Keywords: sirt1 activation; fibrosis; xinyin tablet; medicine ... See more keywords
SIRT1 Activation by Natural Phytochemicals: An Overview
Sign Up to like & getrecommendations! Published in 2020 at "Frontiers in Pharmacology"
DOI: 10.3389/fphar.2020.01225
Abstract: Sirtuins are class III histone deacetylases, whose enzymatic activity is dependent on NAD+ as a cofactor. Sirtuins are reported to modulate numerous activities by controlling gene expression, DNA repair, metabolism, oxidative stress response, mitochondrial function,… read more here.
Keywords: sirt1; phytochemicals overview; sirt1 activation; natural phytochemicals ... See more keywords
SIRT1 activation and its effect on intercalated disc proteins as a way to reduce doxorubicin cardiotoxicity
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Pharmacology"
DOI: 10.3389/fphar.2022.1035387
Abstract: According to the World Health Organization, the neoplasm is one of the main reasons for morbidity and mortality worldwide. At the same time, application of cytostatic drugs like an independent type of cancer treatment and… read more here.
Keywords: sirt1 activation; effect; activation effect; effect intercalated ... See more keywords
SIRT1 Activation Suppresses Corneal Endothelial–Mesenchymal Transition via the TGF-β/Smad2/3 Pathway
Sign Up to like & getrecommendations! Published in 2024 at "Current Issues in Molecular Biology"
DOI: 10.3390/cimb46120827
Abstract: Endothelial–mesenchymal transition (EnMT) is the transversion of endothelial cells to mesenchymal cells under certain physiological or pathological conditions. When EnMT occurs in the corneal endothelium, corneal endothelial cells (CECs) lose their normal function and thus… read more here.
Keywords: smad2 pathway; sirt1 activation; tgf smad2; sirt1 ... See more keywords