Nicotinamide, a vitamin B3 ameliorates depressive behaviors independent of SIRT1 activity in mice
Sign Up to like & getrecommendations! Published in 2020 at "Molecular Brain"
DOI: 10.1186/s13041-020-00703-4
Abstract: Sirtuin 1 (SIRT1), is a nicotinamide adenine dinucleotide (NAD + )-dependent protein deacetylase and a candidate gene for depression. Nicotinamide (NAM), a form of vitamin B3, is reported as a potential inhibitor of SIRT1. Our… read more here.
Keywords: independent sirt1; depression; depressive behaviors; sirt1 activity ... See more keywords
The Role of Sirt1 in Epileptogenesis
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DOI: 10.1523/eneuro.0301-16.2017
Abstract: Abstract The mechanisms by which brain insults lead to subsequent epilepsy remain unclear. Insults, including trauma, stroke, tumors, infections, and long seizures [status epilepticus (SE)], create a neuronal state of increased metabolic demand or decreased… read more here.
Keywords: sirt1; role sirt1; epileptogenesis; blocking sirt1 ... See more keywords
Decreased SIRT1 Activity Is Involved in the Acute Injury Response of Chondrocytes to Ex Vivo Injurious Mechanical Overload
Sign Up to like & getrecommendations! Published in 2023 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms24076521
Abstract: A better understanding of molecular events following cartilage injury is required to develop treatments that prevent or delay the onset of trauma-induced osteoarthritis. In this study, alterations to SIRT1 activity in bovine articular cartilage explants… read more here.
Keywords: sirt1 activity; mechanical overload; injury response; activity ... See more keywords